Anti-Tumor-Promoting Activities of Triterpenoid Glycosides; Cancer Chemoprevention by Saponins
The mechanism of chemical carcinogenesis has been explained by either a two-stage theory or a multi-stage theory which consists of initiation, promotion and progression stages.1 In these stages, the promotion stage is long-term and reversible reaction, and the development of anti-tumor-promoters has been regarded as the most effective method for the chemoprevention of cancer.
KeywordsPanax Ginseng Raji Cell MeOH Extract Hyperplastic Nodule Panax Notoginseng
Unable to display preview. Download preview PDF.
- 1.I. Berenblum, The mechanism of carcinogenesis, a study of the significance of cocarcinogenic action and related phenomea, Cancer Res., 1: 807 (1941)Google Scholar
- 2.T. Konoshima, E. Okamoto, M. Kozuka, H. Nishino, H. Tokuda, and M. Tanabe, Studies on inhibitors of skin tumor promotion, III. Inhibitory effects of isoflavonoids from Wistaria brachybotrys on Epstein-Barr virus activation, J. Nat. Prod., 51: 1266 (1988); M. Takasaki, T. Konoshima, M. Kozuka, and H. Tokuda, Anti-tumor-promoting activities of euglobals from Eucalyptus plants, Biol. Pharm. Bull., 18: 435 (1995).Google Scholar
- 3.T. Konoshima, M. Takasaki, M. Kozuka, T. Nagao, H. Okabe, N. Irino, T. Nakatsu, H. Tokuda, and H. Nishino, Inhibitory effects of cucurbitane triterpenoids on Epstein-Barr virus activation and two-stage carcinogenesis of skin tumor II., Biol. Pharm. Bull.,18: 284 (1955), and references cited there in.Google Scholar
- 6.T. Konoshima, and T. Sawada, Legume saponins of Gleditsia japonica Miguel IV, 13C-NMR spectral studies on structure elucidation of saponin B and C, Chem. Pharm. Bull.,30: 2747 (1982), and references cited therein.Google Scholar
- 7.T. Konoshima, M. Kozuka, T. Sawada, and T. Kimura, Studies on the constituents of Leguminous plants IX, The structure of new triterpenoid saponin from the fruits of Gymnocladus chinensis Baillon, Chem. Pharm Bull.,35: 46 (1987), and references cited therein.Google Scholar
- 8.Tanaka and R. Kasai, Progress in the Chemistry of Organic Natural Products, W. Herz, H. Grisebach, G.W. Kirby, and Ch. Tamm, Ed, Springer-Verlag, New York (1984); I. Kitagawa, T. Taniyama, T. Hayashi, and M. Yoshikawa, Malonyl ginsenosides Rb,, Rb2 and Rd, four new malonylated dammarane-type triterpene glycosides from ginseng radix, Chem. Pharm. Bull., 31: 3353 (1983); S. Sanada, N. Kondo, J. Shoji, O. Tanaka, and S. Shibata, Studies of saponins of ginseng I, structures of ginsenoside-Ro, -Rb„ -Rb2, -Rc and -Rd, Chem. Pharm. Bull., 22: 421 (1974).Google Scholar
- 11.T. Konoshima, M. Takasaki, H. Tokuda, and H. Nishino, Chemopreventive effects of Panax notoginseng on hepatic carcinogenesis, Proc. 10th Symposium on the Development aryl Application of Naturally Occurring Drug Materials (Chiba) p. 45 (1995).Google Scholar