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Hemolytic Activity of Triterpene Glycosides from the Dendrochirotida Order Holothurian

  • Vladimir I. Kalinin
  • Nina G. Prokofieva
  • Galina N. Likhatskaya
  • Elena B. Shentsova
  • Irina G. Agafonova
  • Sergey A. Avilov
  • Olga A. Drozdova
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 404)

Abstract

Triterpene glycosides from sea cucumbers are taxonomically specific,complicated and variable in their chemical structures and biological activities1. As well known cytotoxic, antifungal, and hemolytic effects of glycosides correlate with each other and due to the glycoside membranotropic action2,3. Hemolytic activity was used as a measure of membranolytic action of these glycosides. Previously we studied the influence of a sulfate group at C-4 of the first xylose residue and length of the carbohydrate chain on the hemolytic activity of triterpene glycosides from Cucumariidae family holothurians4. However, questions concerning the influence on the membranolytic activity of sulfate groups attached to the C-6 position of monosaccharide residues in the carbohydrate chains, 3-Omethyl groups in terminal monosaccharide residues, and 16 -oxo groups in aglycones with the 7(8)-double bond remained unresolved. Herein we report studies on hemolytic activity of glycosides and their derivatives from the sea cucumber order Dendrochirotida which attempt to resolve the above-mentioned questions.

Keywords

Loss Rate Sulfate Group Hemolytic Activity Carbohydrate Chain Triterpene Glycoside 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Vladimir I. Kalinin
    • 1
  • Nina G. Prokofieva
    • 1
  • Galina N. Likhatskaya
    • 1
  • Elena B. Shentsova
    • 1
  • Irina G. Agafonova
    • 1
  • Sergey A. Avilov
    • 1
  • Olga A. Drozdova
    • 1
  1. 1.Pacific Institute of Bioorganic Chemistry of Far East DivisionRussian Academy of SciencesVladivostokRussia

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