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New Biologically Active Steroidal and Triterpenoid Glycosides from Medicinal Plants

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Saponins Used in Traditional and Modern Medicine

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 404))

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Abstract

As a consequence of the renewed interest in the search for new substances of natural origin as potential candidates in drug development, since 1980 our research group has been investigating higher plants employed in Italian, Chinese, African and South American traditional medicine.

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References

  1. R. Cerri, R. Aquino, F. De Simone, and C. Pizza, New quinovic acid glycosides from Uncaria tomentosa, J. Nat. Prod., 51: 257 (1988).

    Article  CAS  Google Scholar 

  2. R. Aquino, F. De Simone, C. Pizza, C. Conti, and M.L. Stein, Plant metabolites: structure and in vitro antiviral activity of quinovic acid glycosides from Uncaria tomentosa and Guettarda platypoda, J. Nat. Prod. 52: 679 (1989).

    Article  PubMed  CAS  Google Scholar 

  3. R. Aquino, V. De Feo, F. De Simone, C. Pizza, and G. Cirino, New compounds and anti-inflammatory activity of Uncaria tomentosa, J. Nat. Prod. 54: 453 (1991).

    Article  PubMed  CAS  Google Scholar 

  4. A.M. Yepez, O.L. de Ugaz, C.M. Alvarez, R. Aquino, V. De Feo, F. De Simone, and C. Pizza, Quinovic acid glycosides from Unearia guianensis, Phytochetnistry 30: 1635 (1991).

    Article  CAS  Google Scholar 

  5. R. Aquino, F. De Simone, C. Pizza, R. Cern, and J. F. De Mello, Quinovic acid glycosides from Guettarda platypoda, Phytochemistry 27: 2927 (1988).

    Article  CAS  Google Scholar 

  6. R. Aquino, F. De Simone, C. Pizza, and J.F. De Mello, Further quinovic acid glycosides from Guettarda platypoda, Phytochemistry 28: 199 (1989).

    Article  CAS  Google Scholar 

  7. N. De Tommasi, S. Piacente, F. De Simone, C. Pizza, and Z.Z.Liang, Characterization of three new triterpenoid saponins from Ardisia japonica, J. Nat. Prod. 56: 1669 (1993).

    Article  PubMed  Google Scholar 

  8. L. Pistelli, A.R. Bilia, A. Marsili, N. De Tommasi, and A. Manunta, Triterpenoids saponins from Bupleurum fruticosum, J. Nat. Prod. 55: 240 (1993).

    Article  Google Scholar 

  9. H..Ishii, I. Kitagawa, K. Matsushita, K. Shirakawa, K. Ton, T. Tozyo, M. Yoshikawa, and Y. Yoshimura, The configuration and conformation of the arabinose moiety in platycodins, saponins isolated from Platycodon grandiflorutn, and mi-saponins from Madhuca longifolia based on carbon-13 hydrogen-1 NMR spectroscopic evidence, Tetrahedron Lea. 23: 1529 (1981).

    Google Scholar 

  10. S. Piacente, C. Pizza, N. De Tommasi, and F. De Simone, New dammarane-type glycosides from Gynostemma pentaphvllum, J. Nat. Prod 58: 512 (1995).

    Article  PubMed  CAS  Google Scholar 

  11. M. Iwamoto, T. Fujioka, H. Okabe, K. Mihashi, and T. Yamauchi, Studies on the constituents of Actinosternma lobatum Maxim. 1. Structures of actinostemmosides A, B, C and D, Dammarane triterpenes glycosides isolated from the Herb, Chem. Pharm. Bull. 35: 553 (1987).

    Article  CAS  Google Scholar 

  12. J. Asakawa, R. Kasai, K. Yamasaki, and O. Tanaka, 13C NMR Study of Ginseng sapogenins and their related dammarane-type triterpenes, Tetrahedron 33: 1935 (1977).

    Google Scholar 

  13. W. Junxian, C. Liangyu, W. Jufen, E. Friedrichs, M. Jores, H. Puff, C. Wein-shin, and E. Breitmeier, Two new dammarane sapogenins from leaves of Panax notoginseng, Planta Med. 45: 167 (1982).

    Article  PubMed  CAS  Google Scholar 

  14. M. Terri, R. Matsuda, M. Sono, and Y. Asawaka, 13C NMR assignments of dammarane triterpenes and dendropanoxide: application of 2D long-range correlation 13C–1H spectra, Magn. Res. Chem. 26: 581 (1988).

    Article  Google Scholar 

  15. R. Pompei, O. Flore, M.A. Marciallis, A. Pani, and B. Loddo, Glycyrrhizic acid inhibits virus growth and inactivates virus particles, Nature 281: 689 (1979).

    Article  PubMed  CAS  Google Scholar 

  16. N. De Tommasi, C. Conti, M. L. Stein, and C. Pizza, Structure and in vitro antiviral activity of triterpenoid saponins from Calendula arvensis, Planta Med. 57: 251 (1991).

    Google Scholar 

  17. R. Aquino, F. De Simone, A. Dini, O. Schettino, and C. Pizza, Oligofurostanosides from Asparagus cochinchinensis, Planta Med. 54: 344 (1988).

    Article  PubMed  Google Scholar 

  18. R. Aquino, I. Behar, F. De Simone, C. Pizza, and M. D’ Agostino, Dioscin and gracillin from Tamus communis, J. Nat. Prod. 48: 502 (1985).

    Article  CAS  Google Scholar 

  19. R. Aquino, I. Behar, F. De Simone, M. D’Agostino, and C. Pizza, Furostanol glycosides from Tamus communis, J. Nat. Prod. 49: 1096 (1986).

    Article  CAS  Google Scholar 

  20. S.B. Singh, R.S. Thakur, and H.R. Schulten, Furostanol saponins from Paris polyphylla structures of polyphyllin G and H, Phytochemistry 21: 2079 (1982).

    Article  CAS  Google Scholar 

  21. R. Aquino, C. Conti, F. De Simone, N. Orsi, C. Pizza, and M.L. Stein, Antiviral activity of constituents of Tamus communis, J. Chemother. 3: 305 (1991).

    PubMed  CAS  Google Scholar 

  22. C.Y. Duh, J.M. Pezzuto, A.D. Kinghorn, S.L. Lenny, and N.R. Farnsworth, Plant anticancer agents XLIV. Cytotoxic constituents from Stizophyllum riparium, J. Nat. Prod. 50: 63 (1987).

    Article  PubMed  CAS  Google Scholar 

  23. S. Yoshimura, H. Narita, K. Hayashi, and H. Mitsuhashi, Studies on the constituents of Asclepiadaceae plants LXI. Isolation of new antitumor-active glycosides from Degea volubilis (L) Benth, Chem. Pharm. Bull. 31: 3971 (1983).

    Article  PubMed  CAS  Google Scholar 

  24. R. Aquino, C. Pizza, N. De Tommasi and F. De Simone, New polyoxypregnane ester derivatives from Leptadenia bastata, J. Nat. Prod. 58: 672 (1995).

    Article  PubMed  CAS  Google Scholar 

  25. N. De Tommasi, F. De Simone, C. Pizza, R. Aquino, and G. Peluso, Further new polyoxypregnane ester derivatives from Leptadenia hastata, J. Nat. Prod. in press.

    Google Scholar 

  26. S. Yoshimura, H. Narita, K. Hayashi, and H. Mitsuhashi, Studies on the constituents of Asclepiadaceae plants LX. Further studies on glycosides with a novel sugar chain containing a pair optically isomeric sugars, D and L-cymarose, from Cynanchum wilfordi, Chem. Pharm. Bull. 33: 2294 (1985).

    Article  Google Scholar 

  27. T. Yamagishi, K. Hayashi, H. Mitsuhashi, M. Imanari, and K. Matsushita, Carbon-13 nuclear magnetic resonance spectroscopy of C/D-cis polyoxypregnanes I., Tetrahedron Lett. 37: 3527 (1973).

    Article  Google Scholar 

  28. Z.X. Zhang, J. Zhou, K. Hayashi, and H. Mitsuhashi, S. Yoshimura, H. Narita, K. Hayashi, and H. Mitsuhashi, Studies on the constituents of Asclepiadaceae plants LVIII. The structures of five glycosides, cynatroside-A, -B, -C, -D, and -E, from the Chinese drug “Pai-wei”, Cynanchum atratum Burge, Chem. Pharm. Bull. 33: 1507 (1985).

    Article  PubMed  CAS  Google Scholar 

  29. T. Nakagawa, K. Hayashi, and H. Mitsuhashi, S. Yoshimura, H. Narita, K. Hayashi, and H. Mitsuhashi, Studies on the constituents of Asclepiadaceae plants LV. The structures of three new glycosides, glaucoside -H, -I, and -J from the Chinese drug “Pai-ch’ien”, Cynanchum glaucescens HandMazz, Chem. Pharm. Bull. 31: 2244 (1983).

    Article  CAS  Google Scholar 

  30. K. Hayashi, I. Ida, Y. Nakao, Y. Nakao and K. Kaneko, Four pregnane glycosides, boucerosides AI, AII, BI and BII from Boucerosia aucheriana, Phytochemistry 27: 3919 (1988).

    Article  CAS  Google Scholar 

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© 1996 Springer Science+Business Media New York

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Aquino, R., De Simone, F., De Tommasi, N., Piacente, S., Pizza, C. (1996). New Biologically Active Steroidal and Triterpenoid Glycosides from Medicinal Plants. In: Waller, G.R., Yamasaki, K. (eds) Saponins Used in Traditional and Modern Medicine. Advances in Experimental Medicine and Biology, vol 404. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1367-8_32

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  • DOI: https://doi.org/10.1007/978-1-4899-1367-8_32

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-1369-2

  • Online ISBN: 978-1-4899-1367-8

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