Glycosidases that Convert Natural Glycosides to Bioactive Compounds
There have been increasing number of scientific reports on the biological activities of the chemical constituents of oriental medicines, including various glycosides. A variety of natural products have been reported to contain a large potential for biological activities that are important for the treatment of human diseases. Unfortunately, the natural products themselves are often either sub-optimal for the desired application or are accompanied by unwanted side effects. Biological transformation often can induce the conversion of an inert substance to a more biologically active compound. The production of new secondary metabolites via biotransformation is an attractive method to lead to valuable derivatization. Thiericke and Rohr (1993) emphasized that biological modifications by use of enzyme-catalyzed reactions could provide several advantages such as regio- and stereoselective reactions, derivatization at various positions, and the psychological advantage of using a natural process.
KeywordsIntestinal Bacterium Ether Linkage Glycyrrhetinic Acid Human Basophil Glycyrrhetic Acid
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