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The pH-Dependent Channels Formed by Cauloside C

  • Galina N. Likhatskaya
  • Dmitry L. Aminin
  • Irina G. Agafonova
  • Sergey N. Gnedoi
  • Elena B. Shentsova
  • Lybov I. Strigina
  • Michail M. Anisimov
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 404)

Abstract

Cauloside C isolated from Caulophyllum robustum Max. was demonstrated to be a naturally occurring triterpene glycoside having a carboxyl group at C-171,2. This glycoside was characterized as hederagenin 3-O-β-d-glucopyranosyl-(1→2)-α-l-arabinoside (Fig. 1) and it was isolated also from some plants such as Acebia quinata Decne3 and Caltha silvestris Worosc4. Some of these plants have been used as folk medicines, and the glycosides of hederagenin are known to be biologically active substances which have been used as analgesic, diuretic, antiinflammatory agents5,6. It was found that cauloside C showed a high cytotoxicity on sea urchin eggs and embryos7, inhibited macromolecular synthesis, suppressed nucleoside and amino acid transport into the cell, and stimulated the loss of UV-absorbing substance from the cell8,9.

Keywords

Bilayer Lipid Membrane Liposomal Membrane Pentacyclic Triterpenoids Main Phase Transition Glycoside Concentration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Galina N. Likhatskaya
    • 1
  • Dmitry L. Aminin
    • 1
  • Irina G. Agafonova
    • 1
  • Sergey N. Gnedoi
    • 1
  • Elena B. Shentsova
    • 1
  • Lybov I. Strigina
    • 1
  • Michail M. Anisimov
    • 1
  1. 1.Pacific Institute of Bioorganic Chemistry of Far East Division of RussianAcademy of SciencesVladivostokRussia

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