The pH-Dependent Channels Formed by Cauloside C
Cauloside C isolated from Caulophyllum robustum Max. was demonstrated to be a naturally occurring triterpene glycoside having a carboxyl group at C-171,2. This glycoside was characterized as hederagenin 3-O-β-d-glucopyranosyl-(1→2)-α-l-arabinoside (Fig. 1) and it was isolated also from some plants such as Acebia quinata Decne3 and Caltha silvestris Worosc4. Some of these plants have been used as folk medicines, and the glycosides of hederagenin are known to be biologically active substances which have been used as analgesic, diuretic, antiinflammatory agents5,6. It was found that cauloside C showed a high cytotoxicity on sea urchin eggs and embryos7, inhibited macromolecular synthesis, suppressed nucleoside and amino acid transport into the cell, and stimulated the loss of UV-absorbing substance from the cell8,9.
KeywordsBilayer Lipid Membrane Liposomal Membrane Pentacyclic Triterpenoids Main Phase Transition Glycoside Concentration
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- 1.L.I. Strigina, N.S. Chetirina, V.V. Isakov, Cauloside C - new triterpene glycoside from Caulophyllum robustum. Identification of cauloside C, Khim. Prirod. Soedin. 5: 619 (1976).Google Scholar
- 2.T. Murakami, M. Nagasava, S. Urayama, T. Satake, New triterpenoid saponins in the rhizome and roots of Caulophyllum robustum Maxim. Yakugaku Zasshi. 88: 321 (1968).Google Scholar
- 10.P. Mueller, D.O. Rudin, H.T. Tien, N. Wescott, Recent progress in surface science. VI. Academic Press, N.Y. (1984).Google Scholar