Abstract
A number of cardiotonic factors have been characterized from the plants Digitalis purpurea, Strophanthus gratus, etc., and from a variety of toads Bufo.1,2 The genin of the plant factors are polyhydroxylated C17-steroids with an α,β-unsaturated γ-lactone attached to C-17 (β) and various sugars attached to C-3 (Fig. 1). The genin of the toad factors (C18 steroids) contains an α-pyrone at C-17 instead of the γ-lactone.
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Nakanishi, K. et al. (1996). Search for an Endogenous Mammalian Cardiotonic Factor. In: Waller, G.R., Yamasaki, K. (eds) Saponins Used in Traditional and Modern Medicine. Advances in Experimental Medicine and Biology, vol 404. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1367-8_20
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DOI: https://doi.org/10.1007/978-1-4899-1367-8_20
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