Effect of Some Saponins on Glucose Transport System

  • Kazuo Yamasaki
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 404)


Glucose is the most important nutrient for many types of cells. Indeed, some tissues, such as our own brain, are almost entirely dependent upon glucose as an energy source. Since glucose is a hydrophilic molecule, its uptake into cells across the hydrophobic core of the plasma needs some help. In mammals, where complex homeostatic mechanisms keep the blood glucose level roughly constant, most cells contain a passive facilitated diffusion system for sugar uptake, called the glucose transporter. Previously, this name was based on its function, however, at present, its substantial structure has been established. It is a protein constituted of about five hundred amino acid residues and localised on the surface of the cell membranes in many tissues and organs. In other words, most cells contain passive facilitated diffusion systems for sugar uptake. There are active. sodium-linked sugar transporters in certain locations, such as the kidney and small intestine, where transepithelial transport against a concentration gradient is required.1


Panax Ginseng Sheep Erythrocyte Ehrlich Ascites Tumor Cell Ginseng Extract Triterpenoid Saponin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    G.W. Gould and G.D. Holman, The glucose transporter family: structure, function and tissue-specific expression, Biochem. J. 295: 329 (1993).PubMedGoogle Scholar
  2. 2.
    S.A. Baldwin, Mammalian passive glucose transporters: members of an ubiquitous family of active and passive transport proteins, Biochim. Biophys. Acta 1154:17 (1993).Google Scholar
  3. 3.
    C. Murakami, K. Myoga, R. Kasai, K. Ohtani, T. Kurokawa, S. Ishibashi, F. Dayrit, W.G. Padolina and K. Yamasaki, Screening of plant constituents for effect on glucose transport activity in Ehrlich ascites tumour cells, Chem. Pharm. Bull. 41: 2129 (1993).PubMedCrossRefGoogle Scholar
  4. 4.
    H. Hasagawa, S. Matsumiya, C. Murakami, T. Kurokawa, R. Kasai, S. Ishibashi and K. Yamasaki, Interaction of Ginseng extract, Ginseng separated fractions, and some triterpenoid saponins with glucose transporters in sheep erythrocytes, Planta Med. 60: 153 (1994).CrossRefGoogle Scholar
  5. 5.
    H. Hasagawa, S. Matsumiya, M. Uchiyama, T. Kurokawa, Y. Inouye, R. Kasai, S. Ishibashi and K. Yamasaki, Inhibitory effect of some triterpenoid saponins on glucose transport in tumour cells and its application to in vivo cytotoxic and antiviral activities, Planta Med. 60: 240 (1994).CrossRefGoogle Scholar
  6. 6.
    K. Yamasaki, C. Murakami, K. Ohtani, R. Kasai, T. Kurokawa, S. Ishibashi, F. Soldati, M. Stöckli and D. Mulz, Effects of standardized Panax ginseng extract G 1 15 on the D-glucose transport by Ehrlich ascites tumour cells, Phytother. Res. 7: 200 (1993).CrossRefGoogle Scholar
  7. 7.
    E. Quisumbing. Medicinal Plants of the Philippines, Katha Publishing Co., Inc., Quezon City (1978).Google Scholar
  8. 8.
    N. Wadood, A. Wadood and S.A.A.Shah, Effect of Tinospora cordifolia on blood glucose and total lipid levels of normal and alloxan-diabetic rabbits, Planta Med. 58: 131 (1992).Google Scholar
  9. 9.
    F. Garcia, The treatment of Diabetes Mellitus by the Use of Different Philippine Medicinal Plants, The 8’h Pacific Science Congress, IV A Botany, 1953, pp. 182.Google Scholar
  10. 10.
    H-X.Kuang, R. Kasai, K. Ohtani, Z-S. Liu, C-H. Yuan and O. Tanaka, Chemical constituents of pericarps of Rosa davurica Pall., a traditional Chinese medicine, Chem. Pharm. Bull. 37: 2232 (1989).CrossRefGoogle Scholar
  11. 11.
    F.W. Wehrli and T. Nishida, The use of carbon-13 nuclear magnetic resonance spectroscopy in natural product chemistry, Fortschr. Chem. Org . Naturstoffe 36: 98 (1979).Google Scholar
  12. 12.
    N.D. Tommasi, F.D. Simone, G. Cirino, C. Cicala and C. Pizza, Hypoglycaemic effects of sesquiterpene glycosides and polyhydroxylated triterpenoids of Eriobotrya japonica, Planta Med. 57: 414 (1991).PubMedCrossRefGoogle Scholar
  13. 13.
    M. Takahashi, K. Osawa, J. Ueda, F. Yamamoto and C-T. Tsai, The components of the plant of Lagerstroemia genus. III. On the structure of the new tannin “Lagertannin” from the leaves of Lagerstroemia spesiosa (L.) Pers., Yakugaku Zasshi 96: 984 (1976)PubMedGoogle Scholar
  14. 14.
    K. Fuji, T. Yamada, E. Fujita and H. Murta, Lythraceae alkaloids. X. Alkaloids of Lagerstroemia subcostata and L. fauriei: a contribution to the chemotaxonomy, Chem. Pharm. Bull. 26: 2515 (1978).CrossRefGoogle Scholar
  15. 15.
    O. Tanaka and R. Kasai, Saponins of Ginseng and related plants, Fortschr. Chem. Org . Naturstoffe 46: 1 (1984).CrossRefGoogle Scholar
  16. 16.
    N.M.Duc, R. Kasai, A. Ito, N.T. Nham, K. Yamasaki and O. Tanaka, Saponins from Vietnamese ginseng, Panax vietnamensis Ha et Grushv. collected in central Vietnam. 1., Chem. Pharm. Bull. 41: 2010 (1993).Google Scholar
  17. 17.
    N.M.Duc, R. Kasai, K. Ohtani, A. Ito, N.T. Nham, K. Yamasaki and O. Tanaka, Saponins from Vietnamese ginseng, Panax vietnamensis Ha et Grushv. collected in central Vietnam. II., Chem. Pharm. Bull. 42: 115 (1994)CrossRefGoogle Scholar
  18. 18.
    N.M.Duc, R. Kasai, K. Ohtani, A. Ito, N.T. Nham, K. Yamasaki and O. Tanaka, Saponins from Vietnamese ginseng, Panax vietnamensis Ha et Grushv. collected in central Vietnam. III., Chem. Pharm. Bull. 42: 634 (1994)CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Kazuo Yamasaki
    • 1
  1. 1.Hiroshima UniversityMinami-ku Hiroshima 734Japan

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