Saponins with Antifilarial Activity from Acacia auriculiformis
The saponins are naturally occurring steroid or triterpenoid glycosides which have the property of forming a soapy lather when shaken with water and producing hemolysis when water solutions are injected into the blood stream. The wide occurrence in nature and varied biological activities of saponins have attracted the attention of mankind from the early stage of civilization. Although the saponins are highly toxic when given intravenously to higher animals, their toxic effects are very much lower when they are administered orally. Many of the saponins of food and feedingstuffs are apparently without significant oral toxicity. In continuation of our chemical studies on naturally occurring bioactive saponins!-10 we took up investigation on the saponins from the fruits of Acacia auriculiformis. This plant is widely distributed throughout India and produces large amounts of fruits which give copious froth when shaken with water in powder form indicating the presence of saponins. The plant is reported to have central nervous system depressant activity.11 Previous phytochemical works reported the isolation of a flavan glycosides12, flavan-3,4-diols, flavanone, flavonol, chalcone and polyhydric poly phenols.13 This paper describes the isolation, structure elucidation and antifilarial activity of the saponins from the plant.
KeywordsSteroidal Saponin Alditol Acetate Aqueous MeOH Acid Lactone Acacia AURICULIFORMIS
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