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New Saponins from Vietnamese Ginseng: Highlights on Biogenesis of Dammarane Triterpenoids

  • Nguyen Minh Duc
  • Ryoji Kasai
  • Kazuhiro Ohtani
  • Aiko Ito
  • Kazuo Yamasaki
  • Nguyen Thoi Nham
  • Osamu Tanaka
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 404)

Abstract

Panax ginseng C. A. Meyer (ginseng) and its two congeners, P. notoginseng (Burk.) F. H. Chen (Sanchi ginseng) and P. quinquefolium L. (American ginseng), are well-known plant drugs which have been widely used in many countries of the world, especially in Asia and North America. These are now cultivated plants, differentiating them from a variety of wild Panax spp., which are morphologically related and distributed from Japan to the Eastern Himalayas. Comparative studies on the saponin composition of P. ginseng and other Panax spp. have been elaborated extensively in view of pharmacological and chemotaxonomical interest.1,2

Keywords

American Ginseng Panax Species Heteronuclear Multiple Bond Connectivity Modify Side Chain Gypenoside XVII 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    a) O. Tanaka, and R. Kasai, Saponins of ginseng and related plants, in: Fortschritte der Chemie Organischer Naturstoffe, Vol. 46, W. Hertz, H. Grisebach, G. W. Kirby, and Ch. Tatum, eds., Springer-Verlag, Wien, New York, (1984); b) O. Tanaka, R. Kasai, and T. Morita, Chemistry of ginseng and related plants: recent advances, Abstracts of Chinese Medicines (The Chinese University of Hong Kong), 1:130 (1986); c) O. Tanaka, Recent studies on glycosides from plant drugs of Hymalaya and southwestern China. Chemo-geographical correlation of Panax species, Pure and Appl. Chem., 62:1281 (1990).Google Scholar
  2. 2.
    S. Shibata, O. Tanaka, J. Shoji, and H: Saito, Economic and Medicinal Plant Research, Vol. I, Academic Press, Inc. ( London) Ltd., (1985).Google Scholar
  3. 3.
    D. K. Long, Information about a new Panax species discovered in Kon Turn province of Vietnam, unpublished document of the Fifth Zone Health Service of Vietnam (1973).Google Scholar
  4. 4.
    H. T. Dung, and I. V. Grushvitsky, Panax vietnamensis, a new Panax species, J. Vietnam Bot., 4: 518 (1985).Google Scholar
  5. 5.
    N. T. Nham, P. V. De, T. C. Luan, N. M. Duc, S. Shibata, O. Tanaka, and R. Kasai, Pharmacognostical and chemical studies on Vietnamese ginseng, Panax vietnamensis Ha et Grushv. (Araliaceae), J. Japn. Bot., 70: 1 (1995).Google Scholar
  6. 6.
    T. Takemoto, S. Akihara, T. Nakajima, and M. Okuhira, Studies on the constituents of Gymnostemma pentaphyllum Makino. II. Structure of gypenosides XV - XXI, Yakugaku Zasshi, 103: 1015 (1983).Google Scholar
  7. 7.
    R. Nie, T. Morita, R. Kasai, J. Zhou, C-Y. Wu, and O. Tanaka, Saponin from Chinese medicinal plants. (1). Isolation and structures of hemslosides, Planta Med., 50: 322 (1984).PubMedCrossRefGoogle Scholar
  8. 8.
    N. M. Duc, N. T. Nham, R. Kasai, A. Ito, K. Yamasaki, and O. Tanaka, Saponins from Vietnamese ginseng, Panax vietnamensis Ha et Grushv. collected in central Vietnam. I., Chem. Pharm. Bull., 41: 2010 (1993).Google Scholar
  9. 9.
    N. M. Duc, R. Kasai, K. Ohtani, A. Ito, N. T. Nham, K. Yamasaki, and O. Tanaka, Saponins from Vietnamese ginseng, Panax vietnamensis Ha et Grushv. collected in central Vietnam. II., Chem. Pharm. Bull., 42: 115 (1994).CrossRefGoogle Scholar
  10. 10.
    N. M. Duc, R. Kasai, K. Ohtani, A. Ito, N. T. Nham, K. Yamasaki, and O. Tanaka, Saponins from Vietnamese ginseng, Panax vietnamensis Ha et Grushv. collected in central Vietnam. III. Chem. Pharm. Bull., 42: 634 (1994).PubMedCrossRefGoogle Scholar
  11. 11.
    J. Asakawa, R. Kasai, K. Yamasaki, and O. Tanaka, 13C NMR study of ginseng sapogenins and their related dammarane type triterpenes, Tetrahedron, 33: 1935 (1977).Google Scholar
  12. 12.
    T. Morita, R. Kasai, O. Tanaka, J. Zhou, T. R. Yang, and S. Shoji, Saponins of Zu-tziseng, rhizomes of Panax japonicus C. A. Meyer var. major (Burk.) C. Y. Wu et K. M. Feng, collected in Yunnan, China, Chem. Pharm. Bull., 30: 4341 (1982).CrossRefGoogle Scholar
  13. 13.
    H. Matsuura, R. Kasai, O. Tanaka, Y-I. Saruwatari, T. Fuwa, and J. Zhou, Futher studies on dammarane saponins of Sanchi-ginseng, Chem. Pharm. Bull., 31: 2281 (1983).CrossRefGoogle Scholar
  14. 14.
    H. Budzikiewics, C. Djerassi, and D. H. Williams, Structure Elucidation of Natural Products by Mass Spectrometry, Holden-Day Inc., San Francisco (1964).Google Scholar
  15. 15.
    C. R. Enzell, R. A. Apleton, and I. Wahlberg, Terpenes and terpenoids, in: Biochemical Applications of Mass Spectrometry, G. R. Waller, ed., John Wiley and Sons, Inc., New York, London, Sidney, Canada (1972).Google Scholar
  16. 16.
    O. Tanaka, and S. Yahara, Dammarane saponins of leaves of Panax pseudo-ginseng subsphimalaicus, Phytochemistry, 17: 1353 (1978).CrossRefGoogle Scholar
  17. 17.
    C. Matsubara, and A. Romo de Vivar, Tetracyclic triterpenes from Parthenium fruticosum, Phytochemistry, 24: 613 (1985).CrossRefGoogle Scholar
  18. 18.
    S. Fujita, K. Ohtani, R. Kasai, and K. Yamasaki, unpublished data (1994).Google Scholar
  19. 19.
    M. L. Vickery, and B. Vickery, Secondary Plant Metabolism, MacMillan Press Ltd., (1981).Google Scholar
  20. 20.
    S. Yahara, The Chemical Study on the Sâponin Composition of the Leaves of Panax spp. ( Ph.D. thesis ), Hiroshima University (1978).Google Scholar
  21. 21.
    S. Shibata, M. Fujita, H. Itokawa, O. Tanaka, and T. Ishii, Studies on the constituents of Japanese and Chinese crude drugs. XI. Panaxadiol, a sapogenin of ginseng roots, Chem. Pharm. Bull., 11: 759 (1963).PubMedCrossRefGoogle Scholar
  22. 22.
    S. Shibata, O. Tanaka, M. Nagai, and T. Ishii, Studies on the constituents of Japanese and Chinese crude drugs. XII. Panaxadiol, a sapogenin of ginseng roots. (2)., Chem. Pharm. Bull., 11: 762 (1963).PubMedCrossRefGoogle Scholar
  23. 23.
    S. Shibata, O. Tanaka, T. Ando, M. Sado, T. Tsushima, and T. Ohsawa, Chemical studies on oriental plant drugs. XIV. Protopanaxadiol, a genuine sapogenin of ginseng saponins, Chem. Pharm. Bull., 14: 595 (1966).PubMedCrossRefGoogle Scholar
  24. 24.
    S. Fujita, R. Kasai, K. Ohtani, K. Yamasaki, C. Ming-Hua, N. Rui-Lin, and O. Tanaka, Dammarane glycosides from aerial part of Neoalsomitra integrifoliola, Phytochemistry, 39: 591 (1995).PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Nguyen Minh Duc
    • 1
  • Ryoji Kasai
    • 2
  • Kazuhiro Ohtani
    • 2
  • Aiko Ito
    • 2
  • Kazuo Yamasaki
    • 2
  • Nguyen Thoi Nham
    • 1
  • Osamu Tanaka
    • 3
  1. 1.Science-Production Union of Ginseng and Medicinal PlantsHo Chi Minh City University of Medicine and PharmacyHo Chi Minh CityVietnam
  2. 2.Institute of Pharmaceutical SciencesHiroshima University School of MedicineMinami-ku, Hiroshima 734Japan
  3. 3.Suzugamine Women’s CollegeNishi-ku, Hiroshima 733Japan

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