Modified Steroidal Glycosides with Potential Biological Activity
Saponins constitute bioactive substances of vegetal origin, having a wide variety of biological activities. Special mention should be made of their antimicrobial and fungicidal activity1,2. The general structure of such compounds may be viewed as consisting of two distinct regions, namely the polysaccharidic chain and the genin part, having a rigid steroid skeleton of the molecule which together represent the biologically active properties of such compounds.
KeywordsSelective Oxidation Periodic Acid Virus Suspension Chlorine Dioxide Sodium Chlorite
Unable to display preview. Download preview PDF.
- 1.A.S. Dimoglo, I.N. Choban, and I.R. Bersuker, Structure-activity corelation for antioxidant and antifungal properties of steroid glycosides, J. Bioorg. Chem. 11: 408 (1985).Google Scholar
- 2.P. Ehrlich, Collected Studies on Immunology, 1906, 2:42–48 cited by R. Arshady, J. Bioact. Comp. Polym. 5: 315 (1990).Google Scholar
- 3.R.M. Ottembrite, in: The Import of Chemistry on Biotechnology, M. Phillips, S.P. Shoemaker, R.D. Middlekauff and R.M. Ottembrite, Eds., ACS Symposium Series, 362:122 (1988).Google Scholar
- 4.R.M. Ottembrite, in Polymeric Drugs and Drugs Delivery Systems, R.L. Dunn and R.M. Ottembrite, Eds., ACS Symposium Series, 469:3 (1991).Google Scholar
- 5.R.G. Douglas, Antiviral drugs, Med. Clin. Amer. 67: 1163 (1983).Google Scholar
- 6.P.K. Kintia, G.V. Lazurievsky, N.N. Balashova, I.I. Suruahin, and V.A. Lyakh, Structure and Biological Activity of Steroid Glycosides of the Spirostan and Furostan Series, Shtiintsa, Kishinev (1987).Google Scholar
- 11.E. Maesawa and T. Kosijama, Properties of 2,3-dicaboxycellulose metallic salts, Cell Chem. Technol. 18: 31 (1984).Google Scholar