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Steroidal Saponins from the Liliaceae Plants and Their Biological Activities

  • Yoshihiro Mimaki
  • Yutaka Sashida
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 404)

Abstract

The steroidal saponins are plant glycosides and they often possess properties such as froth forming, hemolytic activity, toxicity to fish, and complex formation with cholesterol. Some of the steroidal saponins isolated recently have been shown to be antidiabetic,1 antitumor,2 antitussive3 and platelet aggregation inhibitors.4 These reports have prompted us to carry out systematic studies on steroidal saponins of the Liliaceae and Agavaceae5 plants. Our studies have resulted in the isolation of a number of new steroidal saponins including cholestane glycosides and steroidal alkaloids, some of which appeared to possess unique chemical structures and exhibited significant biological activities. In this review, we present steroidal compounds with novel structural features. The positive inotropic effects of steroidal and triterpene saponins associated with inhibition of cAMP phosphodiesterase (PDE) and antitumor activities of cholestane glycosides are also presented.

Keywords

Large Cell Carcinoma Triterpene Glycoside Steroidal Saponin Triterpene Saponin Steroidal Glycoside 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Yoshihiro Mimaki
    • 1
  • Yutaka Sashida
    • 1
  1. 1.School of PharmacyTokyo University of Pharmacy and Life ScienceTokyoJapan

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