Skip to main content
SpringerLink
Log in

Prostaglandins and Related Compounds Lipid Messengers with Many Actions

  • Chapter
Lipid Second Messengers

Part of the book series: Handbook of Lipid Research ((HLRE,volume 8))

Abstract

Prostaglandins are oxidized derivatives of arachidonic acid that are produced by many tissues in response to specific stimuli. These biologically active lipids are not stored within cells but rather synthesized and released on stimulation to function in an autocrine or paracrine fashion. Prostaglandins serve diverse physiological and pathophysiological functions, affecting all major systems of the body, and mediating such physiological processes as vascular homeostasis, renal water absorption, ovulation, and parturition. In addition, prostaglandins have been implicated as pathological mediators in thrombosis, asthma, and inflammatory disorders such as arthritis.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Abramovitz, M., Boie, Y.., Nguyen, T., Rushmore, T. H., Bayne, M. A., Metters, K. M., Slipetz, D. M., and Grygorczyk, R., 1994, Cloning and expression of a cDNA for the human prostanoid FP receptor,/ Biol. Chem. 269: 2632–2636.

    CAS  Google Scholar 

  • Baer, A. N., and Green, F. A., 1993, Fatty acid oxygenase activity of human hair roots, j Lipid Res. 34: 1505–1514.

    PubMed  CAS  Google Scholar 

  • Bandyopadhyay, G., Imagawa, W., Wallace, D., and Nandi, S., 1987, Linoleate metabolites enhance the in vitro proliferative response of mouse mammary epithelial cells to epidermal growth factor, ) Biol. Chem. 262: 2750–2756.

    CAS  Google Scholar 

  • Bang, H. O., Dyerberg, J., and Hjorne, N., 1976, The composition of food consumed by Greenland Eskimos, Acta Med. Scand. 200: 69–73.

    Article  PubMed  CAS  Google Scholar 

  • Barbour, S. E., and Dennis, E. A., 1993, Antisense inhibition of group II phospholipase A2 expression blocks the production of prostaglandin E2 by P388D, cells, J. Biol. Chem. 268: 21875–21882.

    PubMed  CAS  Google Scholar 

  • Belanger, C., Buring, J. E., Cook, N., Eberlein, K., Goldhaber, S. Z., Gordon, D., and Hennekens, C. H., 1988, Preliminary Report: Findings from the aspirin component of the ongoing Physicians’ Health Study, N. Engl. J. Med. 318: 262–264.

    Article  Google Scholar 

  • Bishai, I., Dinarello, C. A., and Coceani, F., 1987, Prostaglandin formation in feline cerebral micro-vessels: Effect of endotoxin and interleukin-1, Can. J. Physiol. Pharmacol. 65: 2225–2230.

    Article  PubMed  CAS  Google Scholar 

  • Boie, Y., Rushmore, T. H., Darmon-Goodwin, A., Grygorczyk, R., Slipetz, D. M., Metters, K. M., and Abramovitz, M.,1994, Cloning and expression of a cDNA for the human prostanoid IP receptor, J Biol. Chem. 269: 12173–12178.

    Google Scholar 

  • Bomalaski, J. S., Lawton, P., and Browning, J. L., 1991, Human extracellular recombinant phospho- lipase A2, induces an inflammatory response in rabbit joints, J. Immunol. 146: 3904–3910.

    PubMed  CAS  Google Scholar 

  • Bordet,J.-C., Guichardant, M., and Lagarde, M., 1986, Arachidonic acid strongly stimulates prostaglandin I3 (PGI3) production from eicosapentaenoic acid in human endothelial cells, Biochem. Biophys. Res. Commun. 135: 403–410.

    Article  Google Scholar 

  • Buchanan, M. R., and Bastida, E., 1988, Endothelium and underlying membrane reactivity with platelets, leukocytes and tumor cells: Regulation by the lipoxygenase-derived fatty acid metabolites, 13-HODE and HETES, Med. Hypotheses 27: 317–325.

    Article  PubMed  CAS  Google Scholar 

  • Carter, C. A., Milholland, R. J., Shea, W., and Ip, M. M., 1983, Effect of the prostaglandin synthetase inhibitor indomethacin on 7,12-dimethylbenz(a)anthracene-induced mammary tumorigenesis in rats fed different levels of fat, Cancer Res. 43: 3559–3562.

    PubMed  CAS  Google Scholar 

  • Channon, J. Y., and Leslie, C. C., 1990, A calcium-dependent mechanism for associating a soluble arachidonoyl-hydrolyzing phospholipase A2 with membrane in the macrophage cell line RAW 264.7, J. Biol. Chem. 265: 5409–5413.

    PubMed  CAS  Google Scholar 

  • Cho, Y, and Ziboh, V. A., 1994a, 13-Hydroxyoctadecadienoic acid reverses epidermal hyperproliferation via selective inhibition of protein kinase Gß activity, Biochem. Biophys. Res. Commun. 201: 257–265.

    Google Scholar 

  • Cho, Y, and Ziboh, V. A., 1994b, Expression of protein kinase C isozymes in guinea pig epidermis: Selective inhibition of PKC-13 activity by 13-hydroxyoctadecadienoic acid-containing diacylglycerol, J. Lipid Res. 35: 913–921.

    PubMed  CAS  Google Scholar 

  • Clark, J. D., Lin, L. L., Kriz, R. W., Ramesha, C. S., Sultzman, L. A., Lin, A. Y., Milona, N., and Knopf, J. L., 1991, A novel arachidonic acid-selective cytosolic PLA2 contains a Cat+-dependent translocation domain with homology to PKC and GAP, Cell 65: 1043–1051.

    Article  PubMed  CAS  Google Scholar 

  • Codde, J. P., and Beilin, L. J., 1986, Prostaglandins and experimental hypertension: A review with special emphasis on the effect of dietary lipids, J. Hypertens. 4: 675–666.

    Article  PubMed  CAS  Google Scholar 

  • Growl, R. M., Stoller, T. J., Conroy, R. R., and Stoner, C. R., 1991, Induction of phospholipase A2 gene expression in human hepatoma cells by mediators of the acute phase response, J Biol. Chem. 266: 2647–2651.

    Google Scholar 

  • Crunkhorn, P., and Willis, A. L., 1969, Actions and interactions of prostaglandins administered intradermally in rat and in man, Ba J Pharmacol. 36: 216P - 217 P.

    CAS  Google Scholar 

  • Daret, D., Blin, P., Dorian, B., Rigaud, M., and Larrue, J., 1993, Synthesis of monohydroxylated fatty acids from linoleic acid by rat aortic smooth muscle cells and tissues: Influence on prostacyclin production, J. Lipid Res. 34: 1473–1482.

    PubMed  CAS  Google Scholar 

  • De Meyer, G. R. Y, Bult, H., Verbeuren, T. J., and Herman, A. G., 1992, The role of endothelial cells in the relaxations induced by 13-hydroxy-and 13-hydroperoxylinoleic acid in canine arteries, Br. J. Pharmacol. 107: 597–603.

    Article  PubMed  Google Scholar 

  • DeWitt, D. L., and Meade, E. A., 1993, Serum and glucocorticoid regulation of gene transcription and expression of the prostaglandin H synthase-1 and prostaglandin H synthase-2 isozymes, Arch. Biochem. Biophys. 306: 94–102.

    Article  PubMed  CAS  Google Scholar 

  • DeWitt, D. L., and Smith, W. L., 1983, Purification of prostacyclin synthase from bovine aorta by immunoaffinity chromatography. Evidence that the enzyme is a hemoprotein, J. Biol. Chem. 258: 3285–3293.

    PubMed  CAS  Google Scholar 

  • DeWitt, D. L., and Smith, W. L., 1988, Primary structure of prostaglandin G/H synthase from sheep vesicular gland determined from the complementary DNA sequence, Proc. Natl. Acad. Sci. USA 85: 1412–1416.

    Article  PubMed  CAS  Google Scholar 

  • DeWitt, D. L., el-Harith, E. A., Kraemer, S. A., Andrews, M.J., Yao, E. F., Armstrong, R. L., and Smith, W. L., 1990, The aspirin and heme-binding sites of ovine and murine prostaglandin endoperoxide synthases, J. Biol. Chem. 265: 5192–5198.

    PubMed  CAS  Google Scholar 

  • Diaz, A., Reginato, A. M., and Jimenez, S. A., 1992, Alternative splicing of human prostaglandin G/H synthase mRNA and evidence of differential regulation of the resulting transcripts by transforming growth factor ßl, interleukin 1ß, and tumor necrosis factor a, J. Biol. Chem. 267: 10816–10822.

    PubMed  CAS  Google Scholar 

  • Dyerberg, J., Bang, H. O., and Hjorne, N., 1975, Fatty acid composition of the plasma lipids in Greenland Eskimos, Am. J. Clin. Nutr. 28: 958–966.

    PubMed  CAS  Google Scholar 

  • Eberhart, C. E., Coffey, R.J., Radhika, A., Giardiello, F. M., Ferrenbach, S., and Dubois, R. N., 1994, Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas, Gastroenterology 107: 1183–1188.

    PubMed  CAS  Google Scholar 

  • Egan, R. W., Paxton, J., and Kuehl, E A., Jr., 1976, Mechanism for irreversible self-deactivation of prostaglandin synthetase, J Biol. Chem. 251: 7329–7335.

    PubMed  CAS  Google Scholar 

  • Ferrari, R. A., Ward, S.J., Zobre, C. M., van Liew, D. K., Perrone, M. H., Connell, M.J., and Haubrich, D. R., 1990, Estimation of the in vivo effect of cyclooxygenase inhibitors on prostaglandin E2 levels in mouse brain, Eur. J. Pharmacol. 179: 25–34.

    Article  PubMed  CAS  Google Scholar 

  • Fletcher, B. S., Kujubu, D. A., Perrin, D. M., and Herschman, H. R., 1992, Structure of the mitogeninducible TISIO gene and demonstration that the TIS10-encoded protein is a functional prostaglandin G/H synthase, J. Biol. Chem. 267: 4338–4344.

    PubMed  CAS  Google Scholar 

  • Funk, C. D., Funk, L. B., Kennedy, M. E., Pong, A. S., and FitzGerald, G. A., 1991, Human platelet/ erythroleukemia cell prostaglandin G/H synthase: cDNA cloning, expression, and gene chromosomal assignment, FASEB J. 5: 2304–2312.

    PubMed  CAS  Google Scholar 

  • Futaki, N., Yoshikawa, K., Hamasaka, Y, Arai, I., Higuchi, S., Itzuka, H., and Otomo, S., 1993, NS-398, a novel non-steroidal anti-inflammatory drug with potent analgesic and antipyretic effects, which causes minimal stomach lesions, Gen. Pharmacol. 24: 105–110.

    Article  PubMed  CAS  Google Scholar 

  • Giardiello, E M., Hamilton, S. R., Krush, A. J., Piantadosi, S., Hylind, L. M., Celano, P., Booker, S. V., Robinson, C. R., and Offerhaus, G. J. A., 1993, Treatment of colonic and rectal adenomas with sulindac in familial adenomatous polyposis, N. Engl. J. Med. 328: 1313–1316.

    Article  PubMed  CAS  Google Scholar 

  • Goetzl, E.J., 1981, Selective feed-back inhibition of the 5-lipoxygenation of arachidonic acid in human T-lymphocytes, Biochem. Biophys. Res. Commun. 101: 344–350.

    Article  PubMed  CAS  Google Scholar 

  • Hara, S., Kudo, I., Chang, H. W., Matsuta, K., Miyamoto, T., and Inoue, K., 1989, Purification and characterization of extracellular phospholipase A2 from human synovial fluid in rheumatoid arthritis, J. Biochem. 105: 395–399.

    PubMed  CAS  Google Scholar 

  • Hemler, M. E., Crawford, C. G., and Lands, W. E. M., 1978, Lipoxygenation activity of purified prostaglandin-forming cyclooxygenase, Biochem. J. 17: 1772–1779.

    Article  CAS  Google Scholar 

  • Herschman, H. R., 1991, Primary response genes induced by growth factors and tumor promoters, Annu. Rev. Biochem. 60: 281–319.

    Article  PubMed  CAS  Google Scholar 

  • Hla, T., and Neilson, K., 1992, Human cyclooxygenase-2 cDNA, Proc. Natl. Acad. Sci. USA 89: 7384–7388.

    Article  PubMed  CAS  Google Scholar 

  • Holtzman, M. J., Turk, J., and Shornick, L. P., 1992, Identification of a pharmacologically distinct prostaglandin H synthase in cultured epithelial cells, J Biol. Chem. 267: 21438–21445.

    PubMed  CAS  Google Scholar 

  • Inoue, H., Nanayama, T., Hara, S., Yokoyama, C., and Tanabe, T., 1994, The cyclic AMP response element plays an essential role in the expression of the human prostaglandin-endoperoxide synthase 2 gene in differentiated U937 monocytic cells, FEBS Lett. 350: 51–54.

    CAS  Google Scholar 

  • Jones, D. A., and Fitzpatrick, R. A., 1990, “Suicide” inactivation of thromboxane A2 synthase. Characteristics of mechanism-based inactivation with isolated enzyme and intact platelets,/ Biol. Chem. 265:20166–20171.

    Google Scholar 

  • Jones, D. A., Carlton, D. P., McIntyre, T. M., Zimmerman, G. A., and Prescott, S. M., 1993, Molecular cloning of human prostaglandin endopero) ide synthase type II and demonstration of expression in response to cytokines, J Biol. Chem. 268: 9049–9054.

    PubMed  CAS  Google Scholar 

  • Kaduce, T. L., Figard, P. H., Leifur, R., and Spector, A. A., 1989, Formation of 9-hydroxyoctadecadienoic acid from linoleic acid in endothelial cells, J. Biol. Chem. 264: 6823–6830.

    PubMed  CAS  Google Scholar 

  • Knapp, H. R., and FitzGerald, G. A., 1989, The antihypertensive effects of fish oil. A controlled study of polyunsaturated fatty acid supplements in essential hypertension, N. Engl. J. Med. 320: 1037–1043.

    Article  PubMed  CAS  Google Scholar 

  • Kosaka, T., Miyata, A., Ihara, H., Hara, S., Sugimoto, T., Takeda, O., Takahashi, E., and Tanabe, T.,1994, Characterization of the human gene (PTGS2) encoding prostaglandin-endoperoxide synthase 2, Eur. J. Biochem. 221: 889–897.

    Google Scholar 

  • Kraemer, S. A., Meade, E. A., and DeWitt, D. L., 1992, Prostaglandin endoperoxide synthase gene structure: Identification of the transcriptional start site and 5’-flanking regulatory sequences, Arch. Biochem. Biophys. 293: 391–400.

    Article  PubMed  CAS  Google Scholar 

  • Kromhout, I., Bosschieter, E. B., and Coulander, C. L., 1985, The inverse relation between fish consumption and 20-year mortality from coronary heart disease, N. Engl. J. Med. 312: 1205–1209.

    Article  PubMed  CAS  Google Scholar 

  • Ku, G., Thomas, C. E., Akeson, A. L., and Jackson, R. L., 1992, Induction of interleukin 113 expression from human peripheral blood monocyte-derived macrophages by 9-hydroxyoctadecadienoic acid, J. Biol. Chem. 267: 14183–14199.

    PubMed  CAS  Google Scholar 

  • Kujubu, D. A., and Herschman, H. R., 1992, Dexamethasone inhibits mitogen induction of the TIS10 prostaglandin synthase cyclooxygenase gene, J. Biol. Chem. 267: 1–4.

    Google Scholar 

  • Kujubu, D. A., Fletcher, B. S., Varnum, B. C., Lim, R. W., and Herschman, H. R., 1991, TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue, J. Biol. Chem. 266: 12866–12872.

    PubMed  CAS  Google Scholar 

  • Kujubu, D. A., Reddy, S. T., Fletcher, B. S., and Herschman, H. R., 1993, Expression of the protein product of the prostaglandin synthase-2/TIS10 gene in mitogen-stimulated Swiss 3T3 cells,/ Biol. Chem. 268: 5425–5430.

    CAS  Google Scholar 

  • Lecomte, M., Laneuville, O., Ji, C., DeWitt, D. L., and Smith, W. L., 1994, Acetylation of human prostaglandin endoperoxide synthase-2 (cyclooxygenase-2) by aspirin, J. Biol. Chem. 269: 1320713215.

    Google Scholar 

  • Leslie, C. C., Voelker, D. R., Channon, J. Y., Wall, M. M., and Zelarney, P. T., 1988, Properties and purification of an arachidonoyl-hydrolyzing phospholipase A2 from a macrophage cell line, RAW 264.7, Biochim. Biophys. Acta 963: 476–492.

    Article  PubMed  CAS  Google Scholar 

  • Lin, L.-L., Lin, A. Y, and Knopf, J. L., 1992, Cytosolic phospholipase A2 is coupled to hormonally regulated release of arachidonic acid, Proc. Natl. Acad. Sci. USA 89: 6147–6151.

    Article  PubMed  CAS  Google Scholar 

  • Lin, L.-L., Wartmann, M., Lin, A. Y, Knopf, J. L., Seth, A., and Davis, R. J., 1993, cPLA2 is phosphorylated and activated by MAP kinase, Cell 72: 269–278.

    Google Scholar 

  • Logan, R. F. A., Little, J., Hawtin, P. G., and Hardcastle, J. D., 1993, Effect of aspirin and non-steroidal anti-inflammatory drugs on colorectal adenomas: Case—control study of subjects participating in the Nottingham faecal occult blood screening programme, Br. Med. J. 307: 285–289.

    Article  CAS  Google Scholar 

  • Maier, J. A. M., Hla, T., and Maciag, T., 1990, Cyclooxygenase is an immediate-early gene induced by interleukin-1 in human endothelial cells, J Biol. Chem. 265: 10805–10808.

    PubMed  CAS  Google Scholar 

  • Marnett, L. J., 1992, Aspirin and the potential role of prostaglandins in colon cancer, Cancer Res. 52: 5575–5589.

    PubMed  CAS  Google Scholar 

  • Marshall, P. J., and Kulmacz, R. J., 1988, Prostaglandin H synthase: Distinct binding sites for cyclooxygenase and peroxidase substrates, Arch. Biochem. Biophys. 266: 162–170.

    Article  PubMed  CAS  Google Scholar 

  • Masferrer,J. L., Seibert, K., Zweifel, B., and Needleman, P., 1992, Endogenous glucocorticoids regulate an inducible cyclooxygenase enzyme, Proc. Natl. Acad. Sci. USA 89: 3917–3921.

    Article  Google Scholar 

  • Masferrer, J. L., Zweifel, B. S., Manning, P. T., Hauser, S. D., Leahy, K. M., Smith, W. G., Isakson, P. C., and Seibert, K., 1994, Selective inhibition of inducible cyclooxygenase 2 in vivo is antiinflammatory and nonuclerogenic, Proc. Natl. Acad. Sci. USA 91: 3228–3232.

    Article  PubMed  CAS  Google Scholar 

  • Meade, E. A., 1992, Kinetic and Pharmacological Characterization of Murine PGH Synthase-1 and PGH Synthase-2, Ph.D. thesis, pp. 21–66, Michigan State University.

    Google Scholar 

  • Meade, E. A., Smith, W. L., and DeWitt, D. L., 1993, Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs, J. Biol. Chem. 268: 6610–6614.

    PubMed  CAS  Google Scholar 

  • Merlie, J. P., Fagan, D., Mudd, J., and Needleman, P., 1988, Isolation and characterization of the complementary DNA for sheep seminal vesicle prostaglandin endoperoxide synthetase (cyclooxygenase), J. Biol. Chem. 263: 3550–3553.

    PubMed  CAS  Google Scholar 

  • Mizuno, K., Yamamoto, S., and Lands, W. E. M., 1982, Effects of non-steroidal anti-inflammatory drugs on fatty acid cyclooxygenase and prostaglandin hydroperoxidase activities, Prostaglandins 23: 743–757.

    PubMed  CAS  Google Scholar 

  • Moncada, S., Ferriera, S. H., and Vane, J. R., 1973, Prostaglandins, aspirin-like drugs and the oedema of inflammation, Nature 246: 217–219.

    Article  PubMed  CAS  Google Scholar 

  • Nakano, J., and Cole, B., 1969, Effects of prostaglandins E1 and F2p on systemic, pulmonary, and splanchnic circulations in dogs, Am. J. Physiol. 217: 222–227.

    PubMed  CAS  Google Scholar 

  • Needleman, P., Raz, A., Minkes, M. S., Ferrendelli, J. A., and Sprecher, H., 1979, Triene prostaglandins: Prostacyclin and thromboxane biosynthesis and unique biological properties, Proc. Natl. Acad. Sci. USA 76: 944–948.

    Article  PubMed  CAS  Google Scholar 

  • Oates, J. A., FitzGerald, G. A., Branch, R. A., Jackson, E. K., Knapp, H. R., and Roberts, L. J., II, 1988, Clinical implications of prostaglandin and thromboxane A2 formation, N. Engl. J. Med. 319: 689–698.

    Article  PubMed  CAS  Google Scholar 

  • O’Banion, M. K., Sadowski, H. B., Winn, V., and Young, D. A., 1991, A serum-and glucocorticoidregulated 4-kilobase mRNA encodes a cyclooxygenase-related protein, J. Biol. Chem. 266: 2326123267.

    Google Scholar 

  • O’Banion, M. K, Winn, V. D., and Young, D. A., 1992, cDNA cloning and functional activity of a glucocorticoid-regulated inflammatory cyclooxygenase, Proc. Natl. Acad. Sci. USA 89: 4888–4892.

    Google Scholar 

  • Otto, J. C., and Smith, W. L., 1994, The orientation of prostaglandin endoperoxide synthases-1 and-2 in the endoplasmic reticulum, J Biol. Chem. 269: 19868–19875.

    PubMed  CAS  Google Scholar 

  • Otto, J. C., DeWitt, D. L., and Smith, W. L., 1993, N-glycosylation of prostaglandin endoperoxide synthases-1 and -2 and their orientations in the endoplasmic reticulum, J Biol. Chem. 268: 1823418242.

    Google Scholar 

  • Picot, D., Loll, P. J., and Garavito, R. M., 1994, The x-ray crystal structure of the membrane protein prostaglandin H2 synthase-1, Nature 367: 243–249.

    Article  PubMed  CAS  Google Scholar 

  • Piechaczyk, M., Yang, J.-Q., Blanchard, J.-M., Jeanteur, P., and Marcu, K. B., 1985, Posttranscriptional mechanisms are responsible for accumulation of truncated c-myc RNAs in murine plasma cell tumors, Celi 42: 589–597.

    Article  CAS  Google Scholar 

  • Pilbeam, C. C., Kawaguchi, H., Hakeda, Y., Voznesensky, O., Mander, C. B., and Raisz, L. G., 1993, Differential regulation of inducible and constitutive prostaglandin endoperoxide synthase in osteoblastic MC3T3–E1 cells, J. Biol. Chem. 268: 25643–25649.

    PubMed  CAS  Google Scholar 

  • Ple, P., and Marnett, L. J., 1989, Alkylaryl sulfides as peroxidase reducing substrates for prostaglandin H synthase, J. Biol. Chem. 264: 13983–13993.

    PubMed  CAS  Google Scholar 

  • Regier, M. K., DeWitt, D. I.., Schindler, M. S., and Smith, W. L., 1993, Subcellular localization of prostaglandin endoperoxide synthase-2 in murine 3T3 cells, Arch. Biochem. Biophys. 301: 439–444.

    Article  CAS  Google Scholar 

  • Riese, J., Hoff, T., Nordhoff, A., DeWitt, D. L., and Resch, K., 1994, Transient expression of prostaglandin endoperoxide synthase-2 during mouse macrophage differentiation, J. Leukocyte Biol. 55: 476–482.

    PubMed  CAS  Google Scholar 

  • Rimarachin, J. A., Jacobson, J. A., Szabo, P., Maclouf, J., Creminon, C., and Weksler, B. B., 1994, Regulation of cyclooxygenase-2 expression in aortic smooth muscle cells, Arterioscler. Thromb. 14: 1021–1031.

    Article  PubMed  CAS  Google Scholar 

  • Ristimaki, A., Garfinkel, S., Wessendorf, J., Macing, T., and HIa, T., 1994, Induction of cyclooxygenase-2 by interleukin-la. Evidence for post-transcriptional regulation, J. Biol. Chem. 269: 11769–11775.

    PubMed  CAS  Google Scholar 

  • Rome, L. H., and Lands, W. E. M., 1975, Structural requirements for time-dependent inhibition of prostaglandin biosynthesis by anti-inflammatory drugs, Proc. Natl. Acad. Sci. USA 72: 4863–4865.

    Article  PubMed  CAS  Google Scholar 

  • Rosen, G. D., Birkenmeier, T. M., Raz, A., and Holtzman, M.J., 1989, Identification of a cyclooxygenaserelated gene and its potential role in prostaglandin formation, Biochem. Biophys. Res. Commun. 164: 1358–1365.

    Article  PubMed  CAS  Google Scholar 

  • Roth, G.J., Stanford, N., Jacobs, J. W., and Majerus, P. W., 1977, Acetylation of prostaglandin synthetase by aspirin. Purification and properties of the acetylated protein from sheep vesicular gland, Biochem. J. 16: 4244–4248.

    Article  CAS  Google Scholar 

  • Roth, G.J., Machuga, E. T., and Ozols, J., 1983, Isolation and covalent structure of the aspirin-modified, active-site region of prostaglandin synthetase, Biochem. J. 22: 4672–4675.

    Article  CAS  Google Scholar 

  • Sakamoto, K., Ezashi, T., Miwa, K., Okuda-Ashitaka, E., Houtani, T., Sugimoto, T., Ito, S., and Hayashi, O., 1994, Molecular cloning and expression of a cDNA of the bovine prostaglandin Fla receptor, J. Biol. Chem. 269: 3881–3886.

    PubMed  CAS  Google Scholar 

  • Sano, H., Hla, T., Maier, J. A. M., Crofford, L. J., Case, J. P., Maciag, T., and Wilder, R. L., 1992, In vivo cyclooxygenase expression in synovial tissues of patients with rheumatoid arthritis and osteoarthritis and rats with adjuvant and streptococcal cell wall arthritis, J Clin. Invest. 89: 97–108.

    Article  PubMed  CAS  Google Scholar 

  • Setty, B. N., Berger, M., and Stuart, M. J., 1987, 13-Hydroxyoctadeca-9,11-dienoic acid (13-HODE) inhibits thromboxane A2 synthesis, and stimulates 12-HETE production in human platelets, Biochem. Biophys. Res. Commun. 148: 528–533.

    Google Scholar 

  • Sharp, J. D., White, D. L., Chiou, X. G., Goodson, T., Gamboa, G. C., McClure, D., Burgett, S., Hoskins, J., Skatrud, P. L., Sportsman, J. R., Becker, G. W., Kang, L. H., Roberts, E. F., and Kramer, R. M., 1991, Molecular cloning and expression of human Ca++-sensitive cytosolic phospholipase A2, J Biol. Chem. 266: 14850–14853.

    PubMed  CAS  Google Scholar 

  • Shaw, G., and Kamen, R., 1986, A conserved AU sequence from the 3’ untranslated region of CM-CSF mRNA mediates selective mRNA degradation, Cell 46: 659–667.

    Article  PubMed  CAS  Google Scholar 

  • Shimokawa, T., and Smith, W. L., 1992, Prostaglandin endoperoxide synthase. The aspirin acetylation region, J. Biol. Chem. 267: 12387–12392.

    PubMed  CAS  Google Scholar 

  • Sirko, S., Bishai, I., and Coceani, F., 1989, Prostaglandin formation in the hypothalamus in vivo: Effect of pyrogens, Am. J Physiol. 256: R616 — R624.

    PubMed  CAS  Google Scholar 

  • Sirois, J., and Richards, J. S., 1992, Purification and characterization of a novel, distinct isoform of prostaglandin endoperoxide synthase induced by human chorionic gonadotropin in granulosa cells of rat preovulatory follicles, J. Biol. Chem. 267: 6382–6388.

    PubMed  CAS  Google Scholar 

  • Sirois, J., Simmons, D. L., and Richards, J. S., 1992, Hormonal regulation of messenger ribonucleic acid encoding a novel isoform of prostaglandin endoperoxide H synthase in rat preovulatory follicles. Induction in vivo and in vitro, J. Biol. Chem. 267: 11586–11592.

    PubMed  CAS  Google Scholar 

  • Smith, W. L., and Borgeat, P., 1985, The eicosanoids: Prostaglandins, thromboxanes, leukotrienes, and hydroxy-eicosaenoic acids, in: Biochemistry of Lipids and Membranes ( D. E. Vance and J. E. Vance, eds.), pp. 325–360, Benjamin/Cummings, Menlo Park, CA.

    Google Scholar 

  • Smith, W. L., and Lands, E. M., 1972, Oxygenation of polyunsaturated fatty acids during prostaglandin biosynthesis by sheep vesicular gland, Biochem. J. 11: 3276–3285.

    Article  CAS  Google Scholar 

  • Smith, W. L., and Marnett, L. J., 1991, Prostaglandin endoperoxide synthase: Structure and catalysis, Biochim. Biophys. Acta 1083: 1–17.

    Article  PubMed  CAS  Google Scholar 

  • Stoll, L. L., Morland, M. R., and Spector, A. A., 1994, 13-HODE increases intracellular calcium in vascular smooth muscle cells, Am. j Physiol. 266: C990 — C996.

    Google Scholar 

  • Sugimoti, Y, Hasumoto, K-y., Namba, T., Irie, A., Katsuyama, M., Negishi, M., Kakiszuka, A., Narumiya, S., and Ichikawa, A., 1994, Cloning and expression of a cDNA for mouse prostaglandin F receptor, J. Biol. Chem. 269: 1356–1360.

    Google Scholar 

  • Thun, M.J., Namboodiri, M. M., and Heath, C. W., Jr., 1991, Aspirin use and reduced risk of fatal colon cancer, N. Engl. J. Med. 325: 1593–1596.

    Article  PubMed  CAS  Google Scholar 

  • Ushikubi, F., Aiba, Y.-I., Nakamura, K.-I., Namba, T., Hirata, M., Mazda, O., Katsura, Y, and Narumiya, S., 1993, Thromboxane A2 receptor is highly expressed in mouse immature thymocytes and mediates DNA fragmentation and apoptosis, J. Exp. Med. 178: 1825–1830.

    Article  PubMed  CAS  Google Scholar 

  • Vanderhoek, J. Y, Bryant, R. W., and Bailey, J. M., 1980, Inhibition of leukotriene biosynthesis by the leukocyte product 15-hydroxy-5,8,11,13-eicosatetraenoic acid, J. Biol. Chem. 255: 10064–10065.

    PubMed  CAS  Google Scholar 

  • van der Ouderaa, F. J., Buytenhek, M., Nugteren, D. H., and van Dorp, D. A., 1977, Purification and characterisation of prostaglandin endoperoxide synthetase from sheep vesicular glands, Biochim. Biophys. Acta 487: 315–331.

    Article  PubMed  Google Scholar 

  • van der Ouderaa, J., Buytenhek, M., Nugteren, D. H., and van Dorp, D. A., 1980, Acetylation of prostaglandin endoperoxide synthetase with acetylsalicyclic acid, Eue. J. Biochem. 109: 383–389.

    Article  Google Scholar 

  • Wong, W. Y. L., and Richards, J. S., 1991, Evidence for two antigenically distinct molecular weight variants of prostaglandin H synthase in the rat ovary, Mol. Endocrinol. 5: 1269–1279.

    Article  PubMed  CAS  Google Scholar 

  • Xie, W., Chipman, J. G., Robertson, D. L., Erikson, R. L., and Simmons, D. L., 1991, Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing, Proc. Natl. Acad. Sci. USA 88: 2692–2696.

    Article  PubMed  CAS  Google Scholar 

  • Xie, W., Merrill, J. R., Bradshaw, W. S., and Simmons, D. L., 1993, Structural determination and promoter analysis of the chicken mitogen-inducible prostaglandin G/H synthase gene and genetic mapping of the murine homolog, Arch. Biochem. Biophys. 300: 247–252.

    Article  PubMed  CAS  Google Scholar 

  • Xie, W., Fletcher, B. S., Anderson, R. D., and Herschman, H. R., 1994, v-src induction of the TIS1O/ PGS2 prostaglandin synthase gene is mediated by an ATF/CRE transcription response element, Mol. Cell. Biol. 14: 6531–6539.

    Google Scholar 

  • Yamagata, K., Andreasson, K. I., Kaufmann, W. E., Barnes, C. A., and Worley, P. E,1993, Expression of a mitogen-inducible cyclooxygenase in brain neurons: Regulated by synaptic activity and glucocorticoids, Neuron 11: 371–386.

    Google Scholar 

  • Yokoyama, C., and Tanabe, T., 1989, Cloning of human gene encoding prostaglandin endoperoxide synthase and primary structure of the enzyme, Biochem. Biophys. Res. Commun. 165: 888–894.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. The Eccles Program in Human Molecular Biology and Genetics and the Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, Utah, 84112, USA

    Elizabeth A. Meade

  2. The Eccles Program in Human Molecular Biology and Genetics and the Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, Utah, 84112, USA

    David A. Jones

  3. Department of Medicine, University of Utah School of Medicine, Salt Lake City, Utah, 84112, USA

    Guy A. Zimmerman

  4. Departments of Medicine and Biochemistry, University of Utah School of Medicine, Salt Lake City, Utah, 84112, USA

    Thomas M. McIntyre

  5. Departments of Medicine and Biochemistry, the Nora Eccles Harrison Cardiovascular Research and Training Institute, and the Eccles Institute of Human Genetics, University of Utah School of Medicine, Salt Lake City, Utah, 84112, USA

    Stephen M. Prescott

Authors
  1. Elizabeth A. Meade
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. David A. Jones
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Guy A. Zimmerman
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Thomas M. McIntyre
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Stephen M. Prescott
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Biochemistry, Duke University Medical Center, 27710, Durham, North Carolina, USA

    Robert M. Bell

  2. Glaxo Wellcome, Inc., Research Triangle Park, North Carolina, USA

    Robert M. Bell

  3. Howard Hughes Medical Institute and Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, 37232, Nashville, Tennessee, USA

    John H. Exton

  4. Departments of Medicine and Biochemistry, the Nora Eccles Harrison Cardiovascular Research and Training Institute, and the Eccles Institute of Human Genetics, University of Utah School of Medicine, 84112, Salt Lake City, Utah, USA

    Stephen M. Prescott

Rights and permissions

Reprints and permissions

Copyright information

© 1996 Springer Science+Business Media New York

About this chapter

Cite this chapter

Meade, E.A., Jones, D.A., Zimmerman, G.A., McIntyre, T.M., Prescott, S.M. (1996). Prostaglandins and Related Compounds Lipid Messengers with Many Actions. In: Bell, R.M., Exton, J.H., Prescott, S.M. (eds) Lipid Second Messengers. Handbook of Lipid Research, vol 8. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1361-6_9

Download citation

  • DOI: https://doi.org/10.1007/978-1-4899-1361-6_9

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-1363-0

  • Online ISBN: 978-1-4899-1361-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation