Abstract
Many agonists increase the concentration of phosphatidic acid (PA) in their target cells. This was initially thought to reflect the action of diacylglycerol kinase on the 1,2-diacylglycerol (DAG) generated by the hydrolysis of phosphoinositides (PI) by phospholipase C (PLC) (Berridge, 1984). However, later experiments indicated that the agonists promoted the formation of DAG and PA from another phospholipid and this was subsequently identified as phosphatidylcholine (PC) in most cell types (Exton, 1990, 1994; Billah and Anthes, 1990).
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References
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Bocckino, S.B., Exton, J.H. (1996). Phosphatidic Acid. In: Bell, R.M., Exton, J.H., Prescott, S.M. (eds) Lipid Second Messengers. Handbook of Lipid Research, vol 8. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1361-6_3
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