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Ultrasound-Mediated Transdermal Drug Delivery

  • Chapter
Topical Drug Bioavailability, Bioequivalence, and Penetration

Abstract

In spite of major research and development efforts in transdermal systems and the many advantages of the transdermal route, impermeability of the human skin is still a major problem that limits the usefulness of the transdermal approach. It is well accepted that the stratum corneum is the major rate-limiting barrier to molecular diffusion through the mammalian epidermis.1,2 Because most drugs do not permeate the skin in therapeutic amounts, chemical and physical approaches have been examined to lower the stratum corneum barrier properties and enhance transdermal permeation.3,4

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Author information

Authors and Affiliations

  1. Department of Chemical Engineering, Ben-Gurion University, Beer-Sheva, 84105, Israel

    Joseph Kost

  2. Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, USA

    Robert Langer

Authors
  1. Joseph Kost
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  2. Robert Langer
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Editor information

Editors and Affiliations

  1. Food and Drug Administration, Rockville, Maryland, USA

    Vinod P. Shah

  2. University of California, San Francisco, California, USA

    Howard I. Maibach

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© 1993 Springer Science+Business Media New York

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Kost, J., Langer, R. (1993). Ultrasound-Mediated Transdermal Drug Delivery. In: Shah, V.P., Maibach, H.I. (eds) Topical Drug Bioavailability, Bioequivalence, and Penetration. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1262-6_4

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  • DOI: https://doi.org/10.1007/978-1-4899-1262-6_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-1264-0

  • Online ISBN: 978-1-4899-1262-6

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