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Clinical Applications of Stereotactic Radiosurgery

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Physical Aspects of Stereotactic Radiosurgery

Abstract

The concept of stereotactic radiosurgery was introduced in 1951 by Leksell [58] to describe a technique developed to create small, well-defined lesions in the brain using stereotactically-directed narrow beams of ionizing radiation. Stereotactic radiosurgery may be characterized as a clinical external-beam radiation-treatment procedure applied to a relatively small volume of intracranial tissue in which the total radiation dose is delivered stereotactically through multiple discrete entry portals or arcs in a single or limited number of fractions; the intent is to damage a designated population of cells within the target volume, while protecting the adjacent normal tissues (Table 6.1). The radiosurgical approach is contrasted with conventional external-beam radiotherapy, which generally involves treatment of a larger tissue volume in which the total dose is delivered in a relatively large number of small daily increments over a period of weeks; here, the intent is to destroy the reproductive capacity of neoplastic cells (Table 6.1).

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References

  1. M Austin-Seymour, J Munzenrider, M Goiten, L Verhey, M Urie, R Gentry, S Birnbaum, D Ruotolo, P McManus, S Skates, R G Ojemann, A Rosenberg, A Schiller, A Koehler, H D Suit. Fractionated proton radiation therapy of chordoma and low-grade chondrosarcoma of the base of the skull. J Neurosurg, 70: 13–17, 1989.

    Article  PubMed  CAS  Google Scholar 

  2. E O Backlund. In P 0 Kohler, G T Ross, editors, Diagnosis and Treatment of Pituitary Tumors,pages 263–266. Excerpta Medica, Amsterdam, 1973.

    Google Scholar 

  3. E O Backlund. Studies on craniopharyngiomas IV. Stereotaxic treatment with radiosurgery. Acta Chir Scand, 139: 344–351, 1973.

    PubMed  CAS  Google Scholar 

  4. E O Backlund, G Bergstrand, U Hierton-Laurell, M Rosenborg, A Wajngot, S Werner. Tumour changes after single dose irradiation by stereotactic radio-surgery in “non-active” pituitary adenomas and prolactinomas. In G Szikla, editor, Stereotactic Cerebral Irradiation, INSERM Symposium No. 12, pages 199–206. Elsevier/North-Holland Press, Amsterdam, 1979.

    Google Scholar 

  5. E O Backlund, T Rähn, B Sarby. Treatment of pinealomas by stereotaxic radiation surgery. Acta Radiol (Ther Phys Biol), 13: 368–376, 1974.

    Article  CAS  Google Scholar 

  6. E O Backlund, T Rähn, B Sarby, A de Schryver, J Wennerstrand. Closed stereotaxic hypophysectomy by means of Co-60 gamma radiation. Acta Radiol (Ther Phys Biol), 11: 545–555, 1972.

    Article  CAS  Google Scholar 

  7. J L Barcia-Salorio, P Roldan, G Hernandez, L Lopez-Gomez. Radiosurgical treatment of epilepsy. Appl Neurophysiol, 48: 400–403, 1985.

    PubMed  CAS  Google Scholar 

  8. O O Betti, Y E Derechinsky. Hyperselective encephalic irradiation with linear accelerator. Acta Neurochir (Wien) [Supply, 33: 385–390, 1984.

    Google Scholar 

  9. D J Brenner, M K Martel, E J Hall. Fractionated regimens for stereotactic radiotherapy of recurrent tumors in the brain. Int J Radiat Oncol Biol Phys, 21: 819–824, 1991.

    Google Scholar 

  10. W Calvo, J W Hopewell, H S Reinhold, T K Yeung. Time and dose-related changes in the white matter of the rat brain after single doses of x-rays. Br J Radiol, 61: 1043–1052, 1988.

    Google Scholar 

  11. J R Castro, J M Collier, P L Petti, V Nowakowski, G T Y Chen, J T Lyman, D Linstadt, G Gauger, P Gutin, M Decker, T L Phillips, K Baken. Charged particle radiotherapy for lesions encircling the brain stem or spinal cord. Int J Radiat Oncol Biol Phys, 17: 477–484, 1989.

    Article  PubMed  CAS  Google Scholar 

  12. D H Char, J R Castro, S M Kroll, A R Irvine, J M Quivey, R D Stone. Five-year follow-up of helium ion therapy for uveal melanoma. Arch Ophthalmol, 108: 209–214, 1990.

    Article  PubMed  CAS  Google Scholar 

  13. A B Chinela, A Zambrano, H J Bunge, J A Guevara, J C Antico, O Alva, C Artes, G Coscia. Gamma Knife radiosurgery in uveal melanomas. In L Steiner, editor, Radiosurgery: Baselines and Trends, pages 161–169. Raven Press, New York, 1992.

    Google Scholar 

  14. F Colombo, A Benedetti, F Pozza, C Marchetti, G Chierego. Radiosurgery using a 4 MV linear accelerator. Acta Radiol (Supplf (Stockh), 369: 603–607, 1986.

    CAS  Google Scholar 

  15. F Colombo, A Benedetti, F Pozza, C Marchetti, G Chierego. Linear accelerator radiosurgery of cerebral arteriovenous malformations. Neurosurgery, 24: 833–839, 1989.

    Article  PubMed  CAS  Google Scholar 

  16. J D Constable, J H Lawrence, J L Born, C A Tobias, P E Ariotti, F F Sangalli, R C Carlson, P Toch. Effect of alpha particle hypophysectomy on disseminated cancer of male breast. J Am Med Assoc, 174: 1720–1723, 1960.

    Article  CAS  Google Scholar 

  17. H Cushing, P Bailey. Tumours Arising from the Blood-vessels of the Brain: Angiomatous Malformations and Hemangioblastomas. Charles C Thomas, Springfield, IL, 1928.

    Google Scholar 

  18. M Decker, J R Castro, D E Linstadt, D Char, P L Petti, J M Quivey, D Ahn. Ciliary body melanoma treated with helium particle irradiation. Int J Radiat Oncol Biol Phys, 19: 243–247, 1990.

    Article  PubMed  CAS  Google Scholar 

  19. M Degerblad, T Rähn, G Bergstrand, M Thorén. Long-term results of stereo-tactic radiosurgery to the pituitary gland in Cushing’s disease. Acta Endocrinol, 112: 310–314, 1986.

    PubMed  CAS  Google Scholar 

  20. E Elomaa. Focal irradiation of the brain: An alternative to temporal lobe resection in intractable focal epilepsy. Med Hypotheses, 6: 501–503, 1980.

    Article  PubMed  CAS  Google Scholar 

  21. R Engenhart, B N Kimmig, K-H Höver, B Wowra, V Sturm, G v Kaick, M Wannenmacher. Stereotactic single high dose radiation therapy of benign intracranial meningiomas. Int J Radiat Oncol Biol Phys, 19: 1021–1026, 1990.

    Google Scholar 

  22. J I Fabrikant, K A Frankel, M H Phillips, R P Levy. Stereotactic heavy charged-particle Bragg peak radiosurgery for intracranial arteriovenous malformations. In M S B Edwards, H J Hoffman, editors, Cerebral Vascular Diseases of Childhood and Adolescence, pages 389–409. Williams Wilkins, Baltimore, 1989.

    Google Scholar 

  23. J I Fabrikant, R P Levy. Radiation therapy of pituitary tumors. In W R Selman, editor, Neuroendocrinology, Williams Wilkins, Baltimore (in press).

    Google Scholar 

  24. J I Fabrikant, R P Levy, G K Steinberg, M H Phillips, K A Frankel, J T Lyman, M P Marks, G D Silverberg. Charged-particle radiosurgery for intracranial vascular malformations. Neurosurg Clin North Am 3: 99–139, 1992.

    CAS  Google Scholar 

  25. J I Fabrikant, J T Lyman, K A Frankel. Heavy charged-particle Bragg peak radiosurgery for intracranial vascular disorders. Radiat Res [Suppi], 104: S244 - S258, 1985.

    Google Scholar 

  26. J I Fabrikant, J T Lyman, Y Hosobuchi. Stereotactic heavy-ion Bragg peak radiosurgery: Method for treatment of deep arteriovenous malformations. Br J Radiol, 57: 479–490, 1984.

    Article  PubMed  CAS  Google Scholar 

  27. J Flickinger. An integrated logistic formula for prediction of complications from radiosurgery. Int J Radiai Oncol Biol Phys, 17: 879–885, 1989.

    Article  CAS  Google Scholar 

  28. K A Frankel, R. P Levy, J I Fabrikant, M H Phillips. Heavy-charged-particle radiosurgery: Rationale and method. In E Alexander, J S Loeffler, L D Lunsford, editors, Stereotactic Radiosurgery. McGraw-Hill, New York (in press).

    Google Scholar 

  29. E S Gragoudas, J M Seddon, K Egan, R Glynn, J Munzenrider, M Austin-Seymour, M Goiten, L Verhey, M Urie, A Koehler. Long-term results of proton beam irradiated uveal melanomas. Ophthalmology, 94: 349–353, 1987.

    PubMed  CAS  Google Scholar 

  30. J Hardy. Transsphenoidal microsurgical treatment of pituitary tumors. In J A Linfoot, editor, Recent Advances in the Diagnosis and Treatment of Pituitary Tumors, pages 375–388. New York, Raven Press, 1979.

    Google Scholar 

  31. A Hirsch, G Norén, H Anderson. Audiologic findings after stereotactic radiosurgery in acoustic neurinomas. Acta Otolaryngol (Stockh), 88: 155–160, 1979.

    Article  CAS  Google Scholar 

  32. J W Hopewell. Late radiation damage to the central nervous system: A radiobiological interpretation. Neuropathol Appl Neurobiol, 5: 329–343, 1979.

    Article  PubMed  CAS  Google Scholar 

  33. R T Johnson. Radiotherapy of cerebral angiomas. With a note on some problems in diagnosis. In H W Pia, J R W Gleave, E Grote, editors, Cerebral Angiomas: Advances in Diagnosis and Therapy, pages 256–267. Springer-Verlag, New York, 1975.

    Chapter  Google Scholar 

  34. R N Kjellberg. Proton beam therapy for arteriovenous malformations of the brain. In H H Schmidek, W H Sweet, editors, Operative Neurosurgical Techniques (Volume 1), pages 911–915. Grune and Stratton, New York, 1988.

    Google Scholar 

  35. R N Kjellberg. Stereotactic Bragg peak proton beam radiosurgery for cerebral arteriovenous malformations. Ann Clin Res, 18 [Suppl 47]: 17–19, 1986.

    PubMed  Google Scholar 

  36. R N Kjellberg, G J Candia. Stereotactic proton beam therapy for cerebral AVMs. Harvard Radiosurgery Update,Chestnut Hill MA, 1990 (abstract).

    Google Scholar 

  37. R N Kjellberg, T Hanamura, K R Davis, S L Lyons, R D Adams. Bragg peak proton-beam therapy for arteriovenous malformations of the brain. N Engl J Med, 309: 269–274, 1983.

    Article  PubMed  CAS  Google Scholar 

  38. R N Kjellberg, B Kliman. Lifetime effectiveness–A system of therapy for pituitary adenomas, emphasizing Bragg peak proton hypophysectomy. In J A Linfoot, editor, Recent Advances in the Diagnosis and Treatment of Pituitary Tumors, pages 269–288. Raven Press, New York, 1979.

    Google Scholar 

  39. R N Kjellberg, J W McMeel, N L McManus, A M Koehler. Pituitary suppression in diabetic retinopathy by proton beam in surgically “unfit” patients. In M F Goldberg, S L Fine, editors, Symposium on the Treatment of Diabetic Retinopathy, pages 249–276. Airlie House, Warrenton, VA (U S Public Health Service Publication No. 1890 ), Arlington, 1968.

    Google Scholar 

  40. R N Kjellberg, A Shintani, A G Franzt, B Kliman: Proton beam therapy in acromegaly. N Engl J Med, 278: 689–695, 1968.

    Article  PubMed  CAS  Google Scholar 

  41. D Kondziolka, L D Lunsford, R J Coffey, D J Bissonette, J C Flickinger. Stereotactic radiosurgery of angiographically occult vascular malformations: Indications and preliminary experience. Neurosurgery, 27: 892–900, 1990.

    Article  PubMed  CAS  Google Scholar 

  42. D Kondziolka, L D Lunsford, R J Coffey, J C Flickinger. Gamma Knife radiosurgery of meningiomas. Stereotact Funct Neurosurg, 57: 11–21, 1991.

    Article  PubMed  CAS  Google Scholar 

  43. D Kondziolka, L D Lunsford, J C Flickinger. Radiosurgery for cranial base chordoma and chondrosarcoma. International Stereotactic Radiosurgery Symposium,Pittsburgh PA, 1991 (abstract).

    Google Scholar 

  44. B Konnov, L Melnikov, O Zargarova, L Lebedeva, N Yalynych, D Karlin. Narrow proton beam therapy for intracranial lesions. In International Workshop on Proton and Narrow Photon Beam Therapy, pages 48–55, Oulu, Finland, 1989.

    Google Scholar 

  45. V A Krymsky, F A Serbinenko, Ye I Minakova, Ye I Luchin, A G Lysacheva, E F Nekipelov, S I Klyuchnikov. Proton beam irradiation of spontaneous arteriosinusal anastomoses of the cavernous sinus area. Med Radiol (Mosk), 32 (8): 57–61, 1987 (in Russian).

    Google Scholar 

  46. R W Laing, J Childs, M Brada. Failure of conventionally fractionated radiotherapy to decrease the risk of hemorrhage in inoperable arteriovenous malformations. Neurosurgery, 30: 872–876, 1992.

    Article  PubMed  CAS  Google Scholar 

  47. D A Larson, P H Gutin, S A Leibel, T L Phillips, P K Sneed, W M Wara. Stereotaxic irradiation of brain tumors. Cancer, 65: 792–799, 1990.

    Article  PubMed  CAS  Google Scholar 

  48. B Larsson, L Leksell, B Rexed, P Sourander, W Mair, B Andersson. The high-energy proton beam as a neurosurgical tool. Nature, 182: 1222–1223, 1958.

    Article  PubMed  CAS  Google Scholar 

  49. J H Lawrence. Heavy particle irradiation of intracranial lesions. In R H Wilkens, S S Rengachary, editors, Neurosurgery, pages 1113–1132. New York, McGraw-Hill, 1985.

    Google Scholar 

  50. J H Lawrence. Proton irradiation of the pituitary. Cancer, 10: 795–798, 1957.

    Article  PubMed  CAS  Google Scholar 

  51. J H Lawrence, J L Born, C A Tobias, R Carlson, F Sangalli, G Welch. Clinical and metabolic studies in patients after alpha particle subtotal or total hypophysectomy. In Medicine in Japan in 1959. Proceedings of the 15th General Assembly of the Japan Medical Congress (Volume 5), pages 859–862, Tokyo, 1959.

    Google Scholar 

  52. J H Lawrence, J A Linfoot. Treatment of acromegaly, Cushing disease and Nelson syndrome. West J Med, 133: 197–202, 1980.

    Google Scholar 

  53. J H Lawrence, C A Tobias, J L Born, J H Linfoot, G J D’Angio. Heavy particles in experiemntal medicine and therapy. J Am Med Assoc, 196: 166170, 1966.

    Google Scholar 

  54. J H Lawrence, C A Tobias, J L Born, C C Wang, J H Linfoot. Heavy-particle irradiation in neoplastic and neurologic disease. J Neurosurg, 19: 717–722, 1962.

    Article  PubMed  CAS  Google Scholar 

  55. J H Lawrence, C A Tobias, J A Linfoot, J L Born, A Gottschalk, R P Kling. Heavy particles, the Bragg curve and suppression of pituitary function in diabetic retinopathy. Diabetes, 12: 490–501, 1963.

    PubMed  CAS  Google Scholar 

  56. L Leksell. Cerebral radiosurgery. I. Gammathalamotomy in two cases of intractable pain. Acta Chir Scand, 134: 585–595, 1968.

    PubMed  CAS  Google Scholar 

  57. L Leksell. Further note on a stereotaxic instrument for man. Kungl Fysiogr Sällsk Lund Förhandl, 25: 138–141, 1955.

    Google Scholar 

  58. L Leksell. The stereotaxic method and radiosurgery of the brain. Acta Chir Scand, 102: 316–319, 1951.

    PubMed  CAS  Google Scholar 

  59. L Leksell. Stereotaxis and Radiosurgery: An Operative System. Charles C Thomas, Springfield IL, 1971.

    Google Scholar 

  60. L Leksell, B Larsson, B Andersson, B Rexed, P Sourander, W Mair. Lesions in the depth of the brain produced by a beam of high energy protons. Acta Radiol, 54: 251–264, 1960.

    Article  Google Scholar 

  61. R P Levy, J I Fabrikant, K A Frankel, M H Phillips, J T Lyman. Charged-particle radiosurgery of the brain. Neurosurg Clin North Am, 1: 955–990, 1990.

    CAS  Google Scholar 

  62. R P Levy, J I Fabrikant, K A Frankel, M H Phillips, J T Lyman. Stereo-tactic heavy-charged-particle Bragg peak radiosurgery for the treatment of intracranial arteriovenous malformations in childhood and adolescence. Neurosurgery, 24: 841–852, 1989.

    Article  PubMed  CAS  Google Scholar 

  63. R P Levy, J I Fabrikant, K A Frankel, M H Phillips, J T Lyman, J H Lawrence, C A Tobias. Heavy-charged-particle radiosurgery of the pituitary gland: Clinical results of 840 patients. Stereotact Funct Neurosurg, 57: 22–35, 1991.

    Article  PubMed  CAS  Google Scholar 

  64. R P Levy, J I Fabrikant, K A Frankel, M H Phillips, G K Steinberg, M P Marks, R L DeLaPaz, F Y S Chuang. Clinical-radiological evaluation of sequelae of stereotactic radiosurgery for intracranial arteriovenous malformations. In L Steiner, editor, Radiosurgery: Baselines and Trends, pages 209–220. Raven Press, New York, 1992.

    Google Scholar 

  65. R P Levy, J I Fabrikant, M H Phillips, K A Frankel, G K Steinberg, M P Marks, R L DeLaPaz, F Y S Chuang, J T Lyman. Clinical results of stereo-tactic heavy-charged-particle radiosurgery for intracranial angiographically occult vascular malformations. In L Steiner, editor, Radiosurgery: Baselines and Trends, pages 221–228. Raven Press, New York, 1992.

    Google Scholar 

  66. R P Levy, E H Lo, J I Fabrikant: Biologic basis for stereotactic radiosurgery. In M H Phillips, editor, Physical Aspects of Stereotactic Radiosurgery, pages 189–238. Plenum Press, New York, 1993.

    Google Scholar 

  67. C Lindquist, L Kihlström, E Hellstrand. Functional neurosurgery–A future for the Gamma Knife? Stereotact Funct Neurosurg, 57: 72–81, 1991.

    Google Scholar 

  68. J A Linfoot. Heavy ion therapy: Alpha particle therapy of pituitary tumors. In J A Linfoot, editor, Recent Advances in the Diagnosis and Treatment of Pituitary Tumors, pages 245–267. Raven Press, New York, 1979.

    Google Scholar 

  69. J A Linfoot, J L Born, J F Garcia, E Manougian, R P Kling, C Y Chong, C A Tobias, R A Carlson, J H Lawrence: Metabolic and ophthalmological observations following heavy particle pituitary suppressive therapy in diabetic retinopathy. In M F Goldberg, S L Fine, editors, Symposium on the Treatment of Diabetic Retinopathy, pages 277–289. Airlie House, Warrenton, VA (U S Public Health Service Publication No. 1890 ), Arlington, 1968.

    Google Scholar 

  70. J A Linfoot, J H Lawrence, J L Born, C A Tobias: The alpha particle or proton beam in radiosurgery of the pituitary gland for Cushing’s disease. N Engl J Med, 269: 597–601, 1963

    Article  PubMed  CAS  Google Scholar 

  71. M E Linskey, L D Lunsford, J C Flickinger. Radiosurgery for acoustic neurinomas: Early experience. Neurosurgery, 26: 736–745, 1990.

    Google Scholar 

  72. M E Linskey, L D Lunsford, J C Flickinger, D Kondziolka. Stereotactic radiosurgery for acoustic tumors. Neurosurg Clin North Am, 3: 191–205, 1992.

    Google Scholar 

  73. E H Lo, J I Fabrikant, R P Levy, K A Frankel, M H Phillips, E L Alpen. A compartmental flow model for assessing response of intracranial AVMs to stereotactic radiosurgery. Neurosurgery, 28: 1251–1259, 1991.

    Google Scholar 

  74. R D Lobato, C Perez, J J Rivas, F Cordobes. Clinical, radiological, and pathological spectrum of angiographically occult intracranial vascular malformations. J Neurosurg, 68: 518–531, 1988.

    Google Scholar 

  75. J S Loeffler, E Alexander III, W M Shea, P Y Wen, H A Fine, H M Kooy, P McL Black. Radiosurgery as part of the initial management of patients with malignant gliomas. J Clinical Oncol, 10: 1379–1385, 1992.

    Google Scholar 

  76. J S Loeffler, H M Kooy, P Y Wen, H A Fine, C W Cheng, E G Mannarino, J S Tsai, E Alexander III. The treatment of recurrent brain metastases with stereotactic radiosurgery. J Clinical Oncol, 8: 576–582, 1990.

    Google Scholar 

  77. J Loeffler, R Siddon, P Wen, L Nedzi, E Alexander III. Stereotactic radio-surgery of the brain using a standard linear accelerator: A study of early and late effects. Radiother Oncol, 17: 321–331, 1990.

    Google Scholar 

  78. N A Lopatkin, V G Khazanov, Ye I Minakova, V A Krymsky. Proton irradiation of the hypophysis in the combined antiandrogenical treatment of cancer of the prostate. Khirurgiia (Soffia), 3: 1–3, 1988 (in Bulgarian).

    Google Scholar 

  79. Y I Luchin, Ye I Minakova, V A Krymsky. Proton beam irradiation of cavernous sinus meningiomas. In International Workshop on Proton and Narrow Photon Beam Therapy, pages 99–100, Oulu, Finland, 1989.

    Google Scholar 

  80. R Luft. The use of hypophysectomy in juvenile diabetes mellitus with vascular complications. Diabetes, 11: 461–462, 1962.

    PubMed  CAS  Google Scholar 

  81. K Lundbaek, R Malmros, H C Anderson, J H Rasmussen, E Bruntse, P H Madsen, V A Jensen. Hypophysectomy for diabetic angiopathy: A controlled clinical trial. In M F Goldberg, S L Fine, editors, Symposium on the Treatment of Diabetic Retinopathy, pages 291–311. Airlie House, Warrenton, VA (U S Public Health Service Publication No. 1890 ), Arlington, 1968.

    Google Scholar 

  82. L D Lunsford, J Flickinger, G Lindner, A Maitz. Stereotactic radiosurgery of the brain using first united states 201 cobalt 60 source Gamma Knife. Neurosurgery, 24: 151–159, 1989.

    Article  PubMed  CAS  Google Scholar 

  83. F M Lyass, Ye I Minakova, S A Rayevskaya, V A Krymsky, Y E Luchin, et al. The role of radiotherapy in the treatment of pituitary adenomas. Med Radiol (Mosk), 34 (8): 12–24, 1989 (in Russian)

    Google Scholar 

  84. M P Marks, R L DeLaPaz, J I Fabrikant, K A Frankel, M H Phillips, R P Levy, D R Enzmann. Imaging of charged-particle stereotactic radiosurgery for intracranial vascular malformations. Part II. Complications. Radiology, 168: 457–462, 1988.

    PubMed  CAS  Google Scholar 

  85. M P Marks, B Lane, G K Steinberg, J I Fabrikant, R P Levy, K A Frankel, M H Phillips. Endovascular treatment of cerebral AVMs following radiosurgery. Am J Neuroradiol (in press).

    Google Scholar 

  86. L W McDonald, J H Lawrence, J L Born, J T Lyman. Delayed radionecrosis of the central nervous system. In J H Lawrence, editor, Semiannual Report. Biology and Medicine. Donner Laboratory and Donner Pavilion. Fall 1967 (UCRL Report No. 18066), pages 173–192. Berkeley, Regents of the University of California, 1967.

    Google Scholar 

  87. L A Melnikov, B A Konnov, N N Yalynych. Radiosurgery of cerebral AVM. In International Workshop on Proton and Narrow Photon Beam Therapy, pages 92–98, Oulu, Finland, 1989.

    Google Scholar 

  88. Ye I Minakova. Review of twenty years proton therapy clinical experience in Moscow. In Proceedings of the Second International Charged Particle Workshop, pages 1–23, Loma Linda, CA, 1987.

    Google Scholar 

  89. Ye I Minakova. Twenty years clinical experience of narrow proton beam therapy in Moscow. In Proceedings of the International Heavy Particle Therapy Workshop, pages 158–162, Paul Scherrer Institute, Villigen, Switzerland, 1990.

    Google Scholar 

  90. Ye I Minakova, L Ye Kirpatovskaya, F M Lyass, R Ya Snigiroya, V A Krymsky. Proton therapy of pituitary adenomas. Med Radiol (Mosk), 28 (10): 7–13, 1983 (in Russian).

    Google Scholar 

  91. Ye I Minakova, V A Krymsky, Ye I Luchin, F A Serbinenko, F M Lyass, G A Gabibov, A G Lysacheva, S N Alexeev, V I Kostyuchenko, E V Belyaikin, A N Nozdracheva, V A Pokhvatova. Proton beam therapy in neurosurgical clinical practice. Med Radiol (Mosk), 32 (8): 36–42, 1987 (in Russian).

    CAS  Google Scholar 

  92. Ye I Minakova, N N Vasil’eva, O V Svyatukhina. Irradiation of the hypophysis with single large dose of high energy protons for advanced breast carcinoma. Med Radiol (Mosk), 22 (1): 33–39, 1977 (in Russian).

    CAS  Google Scholar 

  93. P Mindus, K Bergström, S E Levander, G Norén, T Hindmarsh, K-A Thuomas. Magnetic resonance images related to clinical outcome after psychosurgical intervention in severe anxiety disorder. J Neurol Neurosurg Psychiatry, 50: 1288–1293, 1987.

    Article  PubMed  CAS  Google Scholar 

  94. G Norén, J Arndt, T Hindmarsch. Stereotactic radiosurgery in cases of acoustic neurinomas. Further experiences. Neurosurgery, 13: 12–22, 1983.

    Article  PubMed  Google Scholar 

  95. G Norén, J Arndt, T Hindmarsch, A Hirsch. Stereotactic radiosurgical treatment of acoustic neurinomas. In L D Lunsford, editor, Modern Stereotactic Neurosurgery, pages 481–489. Martinus Nijhoff Publishing, Boston, 1988.

    Chapter  Google Scholar 

  96. G Norén, D Greitz, A Hirsch, I Lax. Gamma Knife radiosurgery in acoustic neurinoma. In L Steiner, editor, Radiosurgery: Baselines and Trends, pages 141–148. Raven Press, New York, 1992.

    Google Scholar 

  97. C B Ostertag, K Weigel, W Birg. CT-changes after long-term interstitial iridiuum-192-irradiation of cerebral gliomas. In G Szikla, editor, Stereotactic Cerebral Irradiation, pages 149–155. Elsevier/North-Holland Press, Amsterdam, 1979.

    Google Scholar 

  98. M H Phillips, K A Frankel, J T Lyman, J I Fabrikant, R P Levy. Comparison of different radiation types and irradiation geometries in stereotactic radiosurgery. Iii J Radiai Oncol Biol Phys, 18: 211–220, 1990.

    Google Scholar 

  99. F Pozza, F Colombo, G Chierego, R C Avanzo, C Marchetti, A Benedetti, L Casentini, D Danielo. Low-grade astrocytomas: Treatment with unconventional fractionated external beam fractionated radiation therapy. Radiology, 171: 565–569, 1989.

    PubMed  CAS  Google Scholar 

  100. A Rodriguez, R P Levy, J I Fabrikant. Experimental central nervous system injury after charged-particle irradiation. In P H Gutin, S A Leibel, G E Sheline, editors, Radiation Injury to the Nervous System, pages 149–182. Raven Press, New York, 1991.

    Google Scholar 

  101. G Rylander. Stereotactic radiosurgery in anxiety and obsessive-compulsive neurosis. In E R hitchcock, H T Ballantine Jr, B A Meyerson, editors, Modern Concepts in Psychiatric Surgery, pages 235–240. Elsevier/North-Holland Press, Amsterdam, 1979.

    Google Scholar 

  102. G K Steinberg, J I Fabrikant, M P Marks, R P Levy, K A Frankel, M H Phillips, L M Shuer, G D Silverberg. Stereotactic heavy-charged-particle Bragg-peak radiation for intracranial arteriovenous malformations. N Engl J Med, 323: 96–101, 1990.

    Google Scholar 

  103. G K Steinberg, R P Levy, J I Fabrikant, K A Frankel, M H Phillips, M P Marks. Stereotactic helium ion Bragg peak radiosurgery for angiographically occult intracranial vascular malformations. Stereotact Funct Neurosurg, 57: 64–71, 1991.

    Google Scholar 

  104. G K Steinberg, R P Levy, M P Marks, J I Fabrikant. Surgical resection of intracranial arteriovenous malformations following Bragg-peak, helium-ion radiosurgery. Congress of Neurological Surgeons Annual Meeting,Orlando FL, 1991 (abstract).

    Google Scholar 

  105. L Steiner. Treatment of arteriovenous malformations by radiosurgery. In C B Wilson and B M Stein, editors, Intracranial Arteriovenous Malformations, pages 295–313. Williams Wilkins, Baltimore, 1984.

    Google Scholar 

  106. L Steiner, D M C Forster, L Leksell, B A Meyerson, J Boëthius. Gammathalamotomy in intractable pain. Acta Neurochir (Wien), 52: 173–184, 1980.

    Article  CAS  Google Scholar 

  107. V Sturm, B Kimmig, B Wowra, J Voges, S Schabbert, W Schlegel, O Pastyr, H Treuer, W J Lorenz. Radiosurgery in malignant brain tumors. In L Steiner, editor, Radiosurgery: Baselines and Trends, pages 155–160. Raven Press, New York, 1992.

    Google Scholar 

  108. V Sturm, B Kober, K H Hover, W Schlegel, R Boesecke, O Pastyr, G H Hartmann, S Schabbert, K zum Winkel, S Kunze, W J Lorenz. Stereotactic percutaneous single dose irradiation of brain metastases with a linear accelerator. Int J Radiai Oncol Biol Phys, 13: 279–282, 1987.

    Article  CAS  Google Scholar 

  109. H D Suit, M Goitein, J Munzenrider, L Verhey, K R Davis, A Koehler, R Linggood, R G Ojemann. Definitive radiation therapy for chordoma and chondrosarcoma of base of skull and cervical spine. J Neurosurg, 56: 377–385, 1982

    Google Scholar 

  110. G Szikla, editor, Stereotactic Cerebral Irradiation, INSERM Symposium No. 1Q. Elsevier/North-Holland Press, Amsterdam, 1979.

    Google Scholar 

  111. M Thorén, T Rähn, K Hall, E O Backlund. Treatment of pituitary-dependent Cushing’s syndrome with closed stereotactic radiosurgery by means of Co-60 gamma radiation. Acta Endocrinol (Copenh), 88: 7–17, 1978.

    Google Scholar 

  112. J K Tiller-Borsich, J R Fike, T L Phillips, R L Davis. Pathology of delayed radiation brain damage: An experimental canine model. Radiai Res, 110: 161–172, 1987.

    Article  Google Scholar 

  113. C A Tobias. Pituitary radiation: Radiation physics and biology. In J A Linfoot, editor, Recent Advances in the Diagnosis and Treatment of Pituitary Tumors, pages 221–243. Raven Press, New York, 1979.

    Google Scholar 

  114. C A Tobias, J H Lawrence, J L Born, R K McCombs, J E Roberts, H O Anger, B V A Low-Beer, C B Huggins. Pituitary irradiation with high-energy proton beams: A preliminary report. Cancer Res, 18: 121–134, 1958.

    PubMed  CAS  Google Scholar 

  115. C A Tobias, J E Roberts, J H Lawrence, B V A Low-Beer, H O Anger, J L Born, R McCombs, C B Huggins. Irradiation hypophysectomy and related studies using 340-Mev protons and 190-Mev deuterons. In Proceedings of the International Conference on the Peaceful Uses of Atomic Energy (Volume 10), pages 95–106, Geneva, 1955.

    Google Scholar 

  116. A J van der Kogel. Central nervous system radiation injury in small animal models. In P H Gutin, S A Leibel, G E Sheline, editors, Radiation Injury to the Nervous System, pages 91–111. Raven Press, New York, 1991.

    Google Scholar 

  117. H R Withers. The biologic basis of radiation therapy. In C A Perez, L W Brady, editors, Principles and Practice of Radiation Oncology, pages 67–98. J B Lippincott, Philadelphia, 1987.

    Google Scholar 

  118. K H Woodruff, J T Lyman, J H Lawrence, C A Tobias, J L Born, J I Fabrikant. Delayed sequelae of pituitary irradiation. Hum Pathol, 15: 48–54, 1984.

    Article  PubMed  CAS  Google Scholar 

  119. L Zografos, L Bercher, E Egger, L Chamot, C Gailloud, S Uffer, C Perret, C Markovits. Treatment of eye tumors by accelerated proton beams. Seven years experience. KIM Mbl Augenheilk, 200: 431–435, 1992 (in French).

    Article  CAS  Google Scholar 

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Authors
  1. Richard P. Levy M.D., Ph.D.
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  2. Jacob I. Fabrikant M.D., Ph.D.
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Editors and Affiliations

  1. Department of Radiation Oncology, University of Washington, 1959 N.E. Pacific Street RC-08, 98195, Seattle, Washington, USA

    Mark H. Phillips Ph.D. (Associate Professor) (Associate Professor)

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Levy, R.P., Fabrikant, J.I. (1993). Clinical Applications of Stereotactic Radiosurgery. In: Phillips, M.H. (eds) Physical Aspects of Stereotactic Radiosurgery. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1253-4_6

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  • DOI: https://doi.org/10.1007/978-1-4899-1253-4_6

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