Abstract
Protons and other heavy charged particles, such as deuterons and helium ions, were the first radiations to be used on a regular basis for stereotactic radiosurgery of intracranial targets [19, 20, 44, 45]. Leksell, Larsson, and colleagues in Sweden [15, 21, 22, 39] extensively explored the effects of focal irradation in the mammalian brain using narrow beams of protons. Lawrence, Tobias, Linfoot, et al [19, 20, 26, 44, 45] developed charged particle radiosurgery for a number of different medical conditions at the Donner Laboratory, Lawrence Berkeley Laboratory (LBL) at the University of California-Berkeley. This early work in the 1950’s and 1960’s presaged the current status of charged particles in radiosurgery. Charged particles were shown to be an effective means of producing small, tightly circumscribed lesions in the brain with little or no damage to intervening or adjacent normal tissue. They exhibited unique advantages relative to photons in their ability to localize the dose and to avoid irradiation of critical brain structures. However, the complexity and expense of the hardware needed to produce them has slowed their integration into general medical practice.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
FH Attix, WC Roesch, E Tochilin. Radiation Dosimetry. Academic Press, Inc., New York, 1968.
GTY Chen, RP Singh, JR Castro, JT Lyman, JM Quivey. Treatment planning for heavy ion radiotherapy. Int J Radiai Oncol Biol Phys, 5: 1809–1819, 1979.
JI Fabrikant, KA Frankel, MH Phillips, RP Levy. Stereotactic heavy charged-particle Bragg peak radiosurgery for intracranial arteriovenous malformations. In MSB Edwards and HJ Hoffman, editors, Cerebral Vascular Diseases of Childhood and Adolescence, chapter 22, Part 2, pages 389–410. Williams and Wilkins, 1989.
JI Fabrikant, RP Levy, MH Phillips, KA Frankel, JT Lyman. Neurosurgical applications of ion beams. Nuclear Instruments and Methods in Physics Research, B40 /41: 1376–1384, 1989.
JI Fabrikant, JT Lyman, Y Hosobuchi. Stereotactic heavy-ion Bragg peak radiosurgery: Method for treatment of deep arteriovenous malformations. Br J Radiol, 57: 479–490, 1984.
VB Graves and TA Duff. Intracranial arteriovenous malformations current imaging and treatment. Investigative Radiology, 25: 952–960, 1990.
B R Griffin, S Hummel Warcola, M R Mayberg, J Eenmaa, J Eskridge, H R Winn. Stereotactic neutron radiosurgery for arteriovenous malformations of the brain. Medical Dosimetry, 13: 179–182, 1988.
RN Kjellberg, KR Davis, S Lyons, W Butler, RD Adams. Bragg peak proton beam therapy for arteriovenous malformations of the brain. Clinical Neurosurgery, 31: 248, 1983.
RN Kjellberg, T Hanamura, KR Davis, SL Lyons, RD Adams. Bragg peak proton beam therapy for arteriovenous malformations of the brain. N Engl J Med, 309: 269–274, 1983.
RN Kjellberg and B Kliman. Lifetime effectiveness—a system of therapy for pituitary adenomas, emphasizing Bragg peak proton hypophysectomy. In JA Linfoot, editor, Recent Advances in the Diagnosis and Treatment of Pituitary Tumors, pages 269–288. Raven Press, New York, 1979.
RN Kjellberg, JW McMeel, NL McManus. Pituitary suppression in diabetic retinopathy by proton beam in surgically unfit patients. In MF Goldberg and SL Fine, editors, Symposium on the Treatment of Diabetic Retinopathy, pages 249–276. Airlie House (U S Public Health Service Publ. No. 1890 ), Arlington, VA, 1968.
RN Kjellberg. Isoeffective dose parameters for brain necrosis in relation to proton radiosurgical dosimetry. In G Szikla, editor, Stereotactic Cerebral Irradiation, INSERM Symposium No. 12, pages 157–166. Elsevier/NorthHolland Press, 1979.
RN Kjellberg. Stereotactic Bragg peak proton radiosurgery method. In G Szikla, editor, Stereotactic Cerebral Irradiation, INSERM Symposium No. 12, pages 93–100. Elsevier/North-Holland Press, 1979.
B Kliman, RN Kjellberg, B Swisher, W Butler. Proton beam therapy of acromegaly: a 20-year experience. Prog Endocr Res Ther, 1: 191–211, 1984.
B Larsson, K Liden, B Sarby. Irradiation of small structures through the intact skull. Acta Radiologica: Therapy, Physics, Biology, 13: 512–534, 1974.
B Larsson and B Sarby. Equipment for radiation surgery using narrow 185 MeV proton beams: Dosimetry and design. Acta Oncologica, 26: 143–158, 1987.
JH Lawrence. Heavy particle irradiation of intracranial lesions. In RH Wilkens and SS Rengachary, editors, Neurosurgery, pages 1113–1132. McGraw-Hill, New York, 1985.
JH Lawrence and JA Linfoot. Treatment of acromegaly, Cushing disease and Nelson syndrome. West J Med, 133: 197–202, 1980.
JH Lawrence, CA Tobias, JA Linfoot, JL Born, A Gottschalk, RP Kling. Heavy particles, the Bragg curve and suppression of pituitary function in diabetic retinopathy. Diabetes, 12: 490–501, 1963.
JH Lawrence, C Tobias, JL Born, CC Wang, JH Linfoot. Heavy-particle irradiation in neoplastic and neurologic disease. J Neurosurg, 19: 717–722, 1962.
L Leksell. The stereotaxic method and radiosurgery of the brain. Acta Chir Scand, 102: 316–319, 1951.
L Leksell, B Larsson, B Andersson, B Rexed, P Sourander, W Mair. Lesions in the depth of the brain produced by a beam of high energy protons. Acta Radiol, 54: 251–264, 1960.
RP Levy, JI Fabrikant, KA Frankel, MH Phillips. Particle beam radio-surgery. In W Friedman, editor, Neurosurgery Clinics of North America. W.B. Saunders, Philadelphia, pp. 955–990: 1990.
RP Levy, JI Fabrikant, KA Frankel, MH Phillips, JT Lyman. Stereotactic heavy-charged-particle Bragg peak radiosurgery for the treatment of intracranial arteriovenous malformations in childhood and adolescence. Neurosurgery, 24: 841–852, 1989.
JA Linfoot. Heavy ion therapy: alpha particle therapy of pituitary tumors. In JA Linfoot, editor, Recent Advances in the Diagnosis and Treatment of Pituitary Tumors, pages 245–267. Raven Press, New York, 1979.
JA Linfoot, JH Lawrence, JL Born, CA Tobias. The alpha particle or proton beam in radiosurgery of the pituitary gland for Cushing’s disease. N Engl J Med, 269: 597–601, 1963.
B Ludewigt, W Chu, M Phillips, T Renner. Accelerated helium-ion beams for radiotherapy and stereotactic radiosurgery. Medical Physics, 13: 36–42, 1991.
JT Lyman and CY Chong. ISAH: a versatile treatment positioner for external radiation therapy. Cancer, 34: 12–16, 1974.
JT Lyman, L Kanstein, F Yeater, JI Fabrikant, KA Frankel. A helium-ion beam for stereotactic radiosurgery of central nervous system disorders. Medical Physics, 13: 695–699, 1986.
JT Lyman, MH Phillips, KA Frankel, JI Fabrikant. Stereotactic frame for neuroradiology and charged particle Bragg peak radiosurgery of intracranial disorders. Int J Radiat Oncol Biol Phys, 16: 1615–1621, 1989.
LA Melnikov, BA Konnov, NN Yalynych. Radiosurgery of cerebral AVM. In International Workshop on Proton and Narrow Photon Beam Therapy, pages 92–98. Oulu, Finland, 1989.
Yel Minakova. Review of twenty years proton therapy clinical experience in Moscow. In Proceedings of the Second International Charged Particle Workshop, pages 1–23. Loma Linda, CA, 1987.
YeI Minakova. Twenty years clinical experience of narrow proton beam therapy in Moscow. In Proceedings of the International Heavy Particle Therapy Workshop. Paul Scherrer Institute, Villigen, Switzerland, 1990.
YeI Minakova, LL Goldin, VS Khoroshkov, GV Makarova, GD Monzul, KK Onosovski. Proton therapy at ITEP. In Proceedings of the International Heavy Particle Therapy Workshop. Paul Scherrer Institute, Villigen, Switzerland, 1990.
YeI Minakova, LYe Kirpatovskaya, FM Lyass, et al. Proton therapy of pituitary adenomas. Med Radiol (Mock), 28 (10): 7–13, 1983. (in Russian).
MH Phillips, KA Frankel, JT Lyman, JI Fabrikant, RP Levy. Comparison of different radiation types and irradiation geometries in stereotactic radiosurgery. Int J Rad Onc Biol Phys, 18: 211–220, 1990.
MH Phillips, M Kessler, F Chuang, KA Frankel, JI Fabrikant, RP Levy. Correlation of cerebral angiography, computed tomography and magnetic resonance images in the stereotactic charged particle radiosurgical treatment of intracranial arteriovenous malformations. Int J Rad Onc Bio Phys, 20: 881–889, 1991.
MH Phillips, KA Frankel, JT Lyman, JI Fabrikant, RP Levy. Heavy charged-particle stereotactic radiosurgery: Cerebral angiography and CT in the treatment of intracranial vascular malformations. Int J Radiat Oncol Biol Phys, 17: 419–426, 1989.
B Sarby. Cerebral radiation surgery with narrow gamma beams. Physical experiments. Acta Radiol Ther Phys Biol, 13: 425, 1974.
G K Steinberg, J I Fabrikant, M P Marks, R P Levy, K A Frankel, M H Phillips, L M Shuer, G D Silverberg. Stereotactic heavy-charged-particle Bragg-peak radiation for intracranial arteriovenous malformations. N Eng J Med, 323: 96–101, 1990.
K Stelzer, B Griffin, J Eskridge, J Eenmaa, M Mayberg, S Hummel, H R Winn. Results of neutron radiosurgery for inoperable arteriovenous malformations of the brain. Medical Dosimetry, 16: 137–141, 1991.
K Stelzer, B Griffin, J Eskridge, J Eenmaa, M Mayberg, S Hummel, H R Winn. Neutron radiosurgery for large inoperable arteriovenous malformations of the brain. Submitted to Neurosurgery.
CA Tobias. Pituitary radiation: radiation physics and biology. In JA Lin-foot, editor, Recent Advances in the Diagnosis and Treatment of Pituitary Tumors, pages 221–243. Raven Press, New York, 1979.
CA Tobias, HO Anger, JH Lawrence. Radiologic use of high energy deuterons and alpha particles. American Journal of Roentgenology, Radium Therapy and Nuclear Medicine, 67: 1–27, 1952.
CA Tobias, JH Lawrence, JL Born, RK McCombs, JE Roberts, HO Anger, BVA Low-Beer, CB Huggins. Pituitary irradiation with high-energy proton beams: a preliminary report. Cancer Res, 18: 121–134, 1958.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1993 Springer Science+Business Media New York
About this chapter
Cite this chapter
Frankel, K.A., Phillips, M.H. (1993). Charged Particle Method. In: Phillips, M.H. (eds) Physical Aspects of Stereotactic Radiosurgery. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1253-4_2
Download citation
DOI: https://doi.org/10.1007/978-1-4899-1253-4_2
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4899-1255-8
Online ISBN: 978-1-4899-1253-4
eBook Packages: Springer Book Archive