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Charged Particle Method

Protons and Heavy Charged Particles

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Book cover Physical Aspects of Stereotactic Radiosurgery

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Abstract

Protons and other heavy charged particles, such as deuterons and helium ions, were the first radiations to be used on a regular basis for stereotactic radiosurgery of intracranial targets [19, 20, 44, 45]. Leksell, Larsson, and colleagues in Sweden [15, 21, 22, 39] extensively explored the effects of focal irradation in the mammalian brain using narrow beams of protons. Lawrence, Tobias, Linfoot, et al [19, 20, 26, 44, 45] developed charged particle radiosurgery for a number of different medical conditions at the Donner Laboratory, Lawrence Berkeley Laboratory (LBL) at the University of California-Berkeley. This early work in the 1950’s and 1960’s presaged the current status of charged particles in radiosurgery. Charged particles were shown to be an effective means of producing small, tightly circumscribed lesions in the brain with little or no damage to intervening or adjacent normal tissue. They exhibited unique advantages relative to photons in their ability to localize the dose and to avoid irradiation of critical brain structures. However, the complexity and expense of the hardware needed to produce them has slowed their integration into general medical practice.

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Authors
  1. Kenneth A. Frankel Ph.D.
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  2. Mark H. Phillips Ph.D.
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Editor information

Editors and Affiliations

  1. Department of Radiation Oncology, University of Washington, 1959 N.E. Pacific Street RC-08, 98195, Seattle, Washington, USA

    Mark H. Phillips Ph.D. (Associate Professor) (Associate Professor)

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© 1993 Springer Science+Business Media New York

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Frankel, K.A., Phillips, M.H. (1993). Charged Particle Method. In: Phillips, M.H. (eds) Physical Aspects of Stereotactic Radiosurgery. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1253-4_2

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  • DOI: https://doi.org/10.1007/978-1-4899-1253-4_2

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-1255-8

  • Online ISBN: 978-1-4899-1253-4

  • eBook Packages: Springer Book Archive

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