Abstract
Our understanding of the adaptation of thyroid function to iodine deficiency rests on the pioneer study of iodine kinetics performed by J.B. Stanbury and his coworkers in an endemic goiter area of Argentina (1). This study published in 1954 showed that, in the presence of an abnormally low iodine supply, the thyroid gland is able to maintain an adequate secretion of thyroid hormones through a stimulation of the iodine trapping mechanism and of the subsequent steps of the intrathyroidal iodine metabolism. The authors postulated that this stimulation was triggered by an increased secretion of the thyroid stimulating hormone (TSH), an hypothesis which has been confirmed when the radioimmuno-assay of TSH became available and which also accounted for the association of endemic goiter with iodine deficiency.
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References
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Ermans, A.M. (1993). Iodine Kinetics in Iodine Deficiency. In: Delange, F., Dunn, J.T., Glinoer, D. (eds) Iodine Deficiency in Europe. NATO ASI Series, vol 241. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1245-9_6
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DOI: https://doi.org/10.1007/978-1-4899-1245-9_6
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