Abstract
The concept of autoregulation of iodide metabolism was established several decades ago and autoregulation was originally defined as the regulation of thyroidal iodine metabolism independent from TSH or other external stimulators, and the major autoregulatory factor was considered to be excess iodide.
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References
M. E. Morton, I. L. Chaikoff and S. Rosenfeld. Inhibition effect of inorganic iodide on the formation in vitro of thyroxine and diiodotyrosine by surviving thyroid tissue. J. Biol. Chem. 154: 381 (1944)
J. Wolff and I. L. Chaikoff. Plasma inorganic as a homeostatic regular of thyroid function. J. Biol. Chem. 174: 555 (1948)
J. Wolff, I. L. Chaikoff. R. C. Goldberg and J. R. Meier. The temporary nature of the inhibitory action of excess iodide on organic iodide synthesis in the normal thyroid. Endocrinology. 45: 504 (1949)
M. S. Raben. The paradoxical effects of thiocyanate and of thyrotropin on the organic binding of iodide by the thyroid in the presence of large amounts of iodide. Endocrinology. 45: 296 (1949)
L. E. Braverman and S. H. Ingbar. Changes in thyroidal function during adaptation to large doses of iodide. J.Clin. Invest. 42: 1216 (1963)
S. Nagataki and S. H. Ingbar. Relation between qualitative and quantitative alterations in thyroid hormone synthesis induced by varying doses of iodide. Endocrinology. 74:731(1964)
S. Nagataki, K. Shizume and K. Nakao. Effect of chronic graded doses of iodide on thyroid hormone synthesis. Endocrinology. 79: 667 (1966)
S. Nagataki, K. Shizume and K. Nakao. Thyroid function in chronic excess iodide ingestion: comparison of thyroidal absolute iodide uptake and degradation of thyroxine in euthyroid Japanese subjects. J. Clin. Endocrinol.Metab. 27: 638 (1967)
A. G. Vagenakis, B. Rapoport, F. Azizi, G. I. Portnay, L. E. Braverman and S. H. Ingbar. Hyperresponse to thyrotropin-releasing hormone accompanying small decreases in serum thyroid hormone concentrations. J. Clin. Invest. 54: 913 (1974)
M. Saberi and R.D. Utiger. Augmentation of thyrotropin response to thyrotropin-releasing hormone following small decreases in serum thyroid hormone concentrations. J. Clin. Endocrinol. Metab. 46: 435 (1975)
H. Ikeda and S. Nagataki. Augmentation of thyrotropin responses to thyrotropin-releasing hormone following inorganic iodide. Endocrinol. Japon. 23: 431 (1976)
D. F. Gardner, R. M. Centor and R. D. Utiger. Effects of low dose oral iodide supplementation on thyroid function in normal men. Clin. Endocrinol. 28: 283 (1988)
C. C. Chow, D. I. W. Phillips, J. H. Lazarus and A. B. Parkes. Effect of low dose iodide supplementation on thyroid function in potentially susceptible subjects: are dietary iodide levels in Britain acceptable ?. Clin. Endocrinol. 34: 413 (1991)
H. Namba, S. Yamashita, H. Kimura, N. Yokoyama, T. Usa, A. Otsuru, M. Izumi and S. Nagataki. Evidence of thyroid volume increase in normal subjects receiving excess iodide. J. Clin. Endocrinol. Metab. (submitted)
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© 1993 Springer Science+Business Media New York
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Nagataki, S. (1993). Autoregulation of Thyroid Function by Iodide. In: Delange, F., Dunn, J.T., Glinoer, D. (eds) Iodine Deficiency in Europe. NATO ASI Series, vol 241. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1245-9_5
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DOI: https://doi.org/10.1007/978-1-4899-1245-9_5
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