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Control of Thryoid Growth

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Iodine Deficiency in Europe

Part of the book series: NATO ASI Series ((NSSA,volume 241))

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Abstract

In adults, the thyroid maintains its size with a slow cell turnover, it retains the capacity to grow by cell hypertrophy and proliferation in response to a stimulus (Dumont et al, 1992). The size and function of the thyroid are controlled by a physiological negative feedback mechanism: the thyroid cell secretes thyroid hormones which inhibit the secretion by pituitary thyrotrophs of thyrotropin (TSH), the thyroid stimulating hormone. Whenever thyroid hormone secretion decreases as in iodine metabolism defects, iodine deficiency or after goitrogen or antithyroid drug administration, TSH secretion increases, causing an activation of thyroid function and growth (Doniach, 1960; Dumont et al., 1989; Dumont, 1971; Larsen, 1982). Iodine supply negatively modulates the action of TSH in iodine deficiency the thyroid is more responsive to TSH and conversely.

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References

  • Adams, D.D., 1980, Thyroid-stimulating autoantibodies, Vitam. Horm. 38:120.

    Google Scholar 

  • Bachrach, L.K., Eggo, M.C., Hintz, R.L., Burrow, G.N., 1988, Insulin-like growth factors in sheep thyroid cells: action, receptors and production, Biochem. Biophys. Res. Commun. 154:861.

    Article  PubMed  CAS  Google Scholar 

  • Brandi, M.L., Rotella, C.M., Mavilia, C., Franceschelli, F., Tanini, A., Toccafondi, R., 1987, Insulin stimulates cell growth of a new strain of differentiated rat thyroid cells, Mol. Cell. Endocrinol. 54:91.

    Article  PubMed  CAS  Google Scholar 

  • Contor, L., Lamy, F., Lecocq, R., Roger, P.P., Dumont, J.E., 1988, Differential protein phosphorylation in induction of thyroid cell proliferation by thyrotropin, epidermal growth factor, or phorbol ester, Mol. Cell. Biol.8:2494.

    PubMed  CAS  Google Scholar 

  • Davies, T.F., Platzer, M., 1986, hCG-induced TSH receptor activation and growth acceleration in FRTL-5 thyroid cells, Endocrinology 118:2149.

    Google Scholar 

  • Doniach, I., 1960, Types of thyroid growth, Brit. med. Bull. 16:99.

    PubMed  CAS  Google Scholar 

  • Dumont, J.E., Vassart, G., Refetoff, C., 1989, Thyroid Disorders, in The Metabolic Basis of inherited disease, CR Scriver, AL Beaudet, WS Sly, D Valle eds, Mc Graw Hill Inc., New York, p. 1843.

    Google Scholar 

  • Dumont, J.E., 1971, The action of thyrotropin on thyroid metabolism, Vit and Horm 29:287.

    Article  CAS  Google Scholar 

  • Dumont, J.E., Lamy, F., Roger, P., and Maenhaut, C., 1992, Physiological and pathological regulation of thyroid cell proliferation and differentiation by thyrotropin and other factors, Physiol Rev 72:667.

    PubMed  CAS  Google Scholar 

  • Emoto, N., Isozaki, O., Arai, M., Murakami, H., Shizume, K., Baird, A., Tsushima, T., Demura, H., 1991, Identification and characterization of basic fibroblast growth factor in porcine thyroids, Endocrinology 128:58.

    Article  PubMed  CAS  Google Scholar 

  • Errick, J.E., Ing, K.W.A., Eggo, M.C., Burrow, G.N., 1986, Growth and differentiation in cultured human thyroid cells: effects of epidermal growth factor and thyrotropin, In vitro 22:28.

    CAS  Google Scholar 

  • Fayet, G., Hovsépian, S., 1985, Strategy of thyroid cell culture in defined media and the isolation of the Ovnis and Porthos cell strains. In: Thyroglobulin. The prothyroid hormone, Raven Press, New York, p. 211.

    Google Scholar 

  • Geelhoed-Duijvestijn, P.H.L.M., Bussemaker, J.K., Roelfsema, F., 1989, Changes in basal and stimulated TSH and other parameters of thyroid function in acromegaly after transsphenoidal surgery, Acta Endocrinologica 121:207.

    PubMed  CAS  Google Scholar 

  • Gérard, C.M., Roger, P.P., Dumont, J.E., 1989, Thyroglobulin gene expression as a differentiation marker in primary cultures of calf thyroid cells, Mol. Cell. Endocrinol. 61:23.

    Article  PubMed  Google Scholar 

  • Greil, W., Rafferzeder, M., Brechtner, G., Gärtner, R., 1989, Release of an endothelial cell growth factor from cultured porcine thyroid follicles, Mol Endocrinol 3:858.

    Article  PubMed  CAS  Google Scholar 

  • Grubeck-Loebenstein, B., Buchan, G., Sadeghi, R., Kissonerghis, M., Londei, M., Turner, M., Pirich, K., Roka, R., Niederle, B., Kassal, H., Waldhäusl, W., Feldman, M., 1989, Transforming growth factor beta regulates thyroid growth, J. Clin. Invest.83:764.

    Article  PubMed  CAS  Google Scholar 

  • Hershman, J.M., Lee, H.Y., Sugawara, M., Mirell, C.J., Pang, X.P., Yanagisawa, M., Pekary, A.E., 1988, Human chorionic gonadotropin stimulates iodide uptake, adenylate cyclase, and deoxyribonucleic acid synthesis in cultured rat thyroid cells, J. Clin. Endocrinol. Metab. 67:74.

    Article  PubMed  CAS  Google Scholar 

  • John, T., Morreale de Escobar, G., Escobar del Rey, F., 1970, Differential effects in the rat of thyroidectomy, propylthiouracil and other goitrogens on plasma insulin and thyroid weight, Endocrinology 87:99.

    Article  Google Scholar 

  • Kasagi, K., Hidaka, A., Hatabu, H., Tokuda, Y., Misaki, T., Iida, Y., Yoshida, M., Fujii, S., Taii, H., Konishi, J., 1989, Stimulation of cyclic AMP production in FRTL-5 cells by crude immunoglobulin fractions of serum from pregnant women, Clin. Endocrinol. 31:267.

    Article  CAS  Google Scholar 

  • Kasai, K., Hiraiwa, M., Suzuki, Y., Emoto, T., Banda, N., Nakamura, T., Shimoda, S.I., 1987, Presence of epidermal growth factor receptors on human thyroid membranes, Acta Endocrinologica 114:396.

    PubMed  CAS  Google Scholar 

  • Lamberg, B.A., Pelkonen, R., Aro, A, Grahne, B., 1976, Thyroid function in acromegaly before and after transsphenoidal hypophysectomy followed by cryoapplication, Acta Endocrinologica 82:254.

    PubMed  CAS  Google Scholar 

  • Larsen, P.R., 1982, Thyroid-pituitary interaction. Feedback regulation of thyrotropin secretion by thyroid hormones, N. Engl. J. Med. 306:23.

    Article  PubMed  CAS  Google Scholar 

  • Laurent, E., Van Sande, J., Ludgate, M., Corvilain, B., Rocmans, P., Dumont, J.E., Mockel, J., 1991, Unlike thyrotropin, thyroid-stimulating antibodies do not activate phospholipase C in human thyroid slices, J. Clin. Invest. 87:1.

    Article  Google Scholar 

  • Levitzki, A., 1990, Tyrphostins-potential antiproliferative agents and novel molecular tools, Biochem. Pharmacol.40:913.

    Article  PubMed  CAS  Google Scholar 

  • Lu, C., Kasagi, K., Hidaka, A., Hatabu, H., Iida, Y., Konishi, J., 1990, Simultaneous measurement of TSH-binding inhibitor immunoglobulin and thyroid stimulating autoantibody activities using cultured FRTL-5 cells in patients with untreated Graves’ disease, Acta Endocrinol. 123:282.

    PubMed  CAS  Google Scholar 

  • Lyons, J., Landis, C.A., Harsh, G., Vallar, L., Grünewald, K., Feichtinger, H., Duh, Q.Y., Clark, O.H., Kawasaki, E., Bourne, H.R., McCormick, F., 1990, Two G protein oncogenes in human endocrine tumors, Science 249:655.

    Article  PubMed  CAS  Google Scholar 

  • Maciel, R.M.B., Mores, A.C., Villone, G., Tramontano, D., Ingbar, S.H., 1988, Demonstration of the production and physiological role of insulin-like growth factor II in rat thyroid follicular cells in culture, J. Clin. Invest. 82:1546.

    Article  PubMed  CAS  Google Scholar 

  • Maenhaut, G., Van Sande, J., Libert, F., Abramowicz, M., Parmentier, M., Vanderhaegen, J.J., Dumont, J.E., Vassart, G., Schiffmann, S., 1990, RDC8 codes for an adenosine A2 receptor with physiological constitutive activity, Biochem. Biophys. Res. Commun. 173:1169.

    Article  PubMed  CAS  Google Scholar 

  • Miyakawa, M., Saji, M., Tsushima, T., Wakai, K., Shizume, K., 1988, Thyroid volume and serum thyroglobulin levels in patients with acromegaly: correlation with plasma insulin-like growth factor I levels, J. Clin. Endocrinol. Metab. 67:973.

    Article  PubMed  CAS  Google Scholar 

  • Moris, III J.G., Ranganathan, C., Hay, I.D., Nelson, R.E., Jiang, N.S., 1988, The effects of transforming growth factor-β on growth and differentiation of the continuous rat thyroid follicular cell line, FRTL-5, Endocrinology 123:1385.

    Article  Google Scholar 

  • Moses, A.C., Tramontano, D., Veneziani, B.M., Frauman, AG, 1989, Adenosine has divergent effects on deoxyribunucleic acid synthesis in FRTL-5 cells: inhibition of thyrotropin-stimulated and potentiation of insulin-like growth factor-I stimulated thymidine incorporation, Endocrinology 125:2758.

    Article  PubMed  CAS  Google Scholar 

  • Ollis, C.A., Davies, R., Munro, D.S., Tomlinson, S., 1986, Relationship between growth and function of human thyroid cells in culture, J. Endocrinol. 108:393.

    Article  PubMed  CAS  Google Scholar 

  • Pekonen, F., Alfthan, H., Stenman, U.H., Ylikorkala, O., 1988, Human chorionic gonadotropin (hCG) and thyroid function in early human pregnancy: circadian variation and evidence for intrinsic thyrotropic activity of hCG, J. Clin. Endocrinol. Metab. 66:853.

    Article  PubMed  CAS  Google Scholar 

  • Reuse, S., Maenhaut, C., Dumont, J.E., 1990, Regulation of protooncogenes c-fos and c-myc expressions by protein tyrosine kinase, protein kinase C., and cyclic AMP mitogenic pathways in dog primary thyrocytes: a positive and negative control by cyclic AMP on c-myc expression, Exp. Cell. Res. 189:33.

    Article  PubMed  CAS  Google Scholar 

  • Roger, P.P., Hotimsky, A., Moreau, C., Dumont, J.E., 1982a, Stimulation by thyrotropin, cholera toxin and dibutyryl cyclic AMP of the multiplication of differentiated thyroid cells in vitro, Mol. Cell. Endocrinol. 26:165.

    Article  PubMed  CAS  Google Scholar 

  • Roger, P.P., Dumont, J.E., 1982b, Epidermal growth factor controls the proliferation and the expression of differentiation in canine thyroid cells in primary culture, FEBS Lett. 144:209.

    Article  PubMed  CAS  Google Scholar 

  • Roger, P.P., Dumont, J.E., 1984, Factors controlling proliferation and differentiation of canine thyroid cells cultured in reduced serum conditions: effects of thyrotropin, cyclic AMP and growth factors, Mol. Cell. Endocrinol. 36:79.

    Article  PubMed  CAS  Google Scholar 

  • Roger, P.P., Reuse, S., Servais, P., Van Heuverswyn, B., Dumont, J.E., 1986, Stimulation of cell proliferation and inhibition of differentiation expression by tumor-promoting phorbol esters in dog thyroid cells in primary culture, Cancer Res. 46:898.

    PubMed  CAS  Google Scholar 

  • Roger, P.P., Servais, P., Dumont, J.E., 1987, Induction of DNA synthesis in dog thyrocytes in primary culture: synergistic effects of thyrotropin and cyclic AMP with epidermal growth factor and insulin, J. Cell. Physiol. 130:58.

    Article  PubMed  CAS  Google Scholar 

  • Roger, P.P., Servais, P., Dumont, J.E., 1983, Stimulation by thyrotropin and cyclic AMP of the proliferation of quiescent canine thyroid cells cultured in a defined medium containing insulin, FEBS Lett. 157:323.

    Article  PubMed  CAS  Google Scholar 

  • Roger, P.P., Taton, M., Van Sande, J., Dumont, J.E., 1988, Mitogenic effects of thyrotropin and cyclic AMP in differentiated human thyroid cells in vitro, J. Clin. Endocrinol. Metab. 66:1158.

    Article  PubMed  CAS  Google Scholar 

  • Roger, P.P., Van Heuverswyn, B., Lambert, C., Reuse, S., Vassart, G., Dumont, J.E., 1985, Antagonistic effects of thyrotropin and epidermal growth factor on thyroglobufin mRNA level in cultured thyroid cells, Eur. J. Biochem. 152:239.

    Article  PubMed  CAS  Google Scholar 

  • Smith, P., Wyndford-Thomas, D., Stringer, B.M.J., Williams, E.D., 1986, Growth factor control of rat thyroid follicular cell proliferation, Endocrinology 119:1439.

    Article  PubMed  CAS  Google Scholar 

  • Takasu, N., Komiya, I., Nagasawa, Y., Asawa, T., Shinoda, T., Yamada, T., Shimizu, Y., 1990a, Stimulation of porcine thyroid cell alkalinization and growth by EGF, phorbol ester, and diacylglycerol, Am. J. Physiol. 258:E445.

    Google Scholar 

  • Takasu, N., Komiya, I., Nagasawa, Y., Asawa, T., Shimizu, Y., Yamada, T., 1990b, Cytoplasmic pH in the action of insulin-like growth factor-I in cultured porcine thyroid cells, J. Endocrinol. 127:305.

    Article  PubMed  CAS  Google Scholar 

  • Takasu, N., Takasu, M., Komiya, I., Nagasawa, Y., Asawa, T., Shimizu, Y., Yamada, T., 1989, Insulin-like growth factor I stimulates inositol phosphate accumulation, a rise in cytoplasmic free calcium, and proliferation in cultured porcine thyroid cells, J. biol. Chem. 264:18485.

    PubMed  CAS  Google Scholar 

  • Takasu, N., Takasu, M., Yamada, T., Shimizu, Y., 1988, Epidermal growth factor (EGF) produces inositol phosphates and increases cytoplasmic free calcium in cultured porcine thyroid cells, Biochem. Biophys. Res. Commun. 151:530.

    Article  CAS  Google Scholar 

  • Tramontano, D., Chin, W.W., Moses, A.C., Ingbar, S.H., 1986a, Thyrotropin and dibutyryl cyclic AMP increase levels of c-myc and c-fos mRNAs in cultured rat thyroid cells, J. Biol. Chem. 261:3919.

    Google Scholar 

  • Tramontano, D., Cushing, G., Moses, A.C., Ingbar, S.H., 1986b, Insulin-like growth factor-I stimulates the growth of rat thyroid cells in culture and synergizes the stimulation of DNA synthesis induced by TSH and Graves’ IgG, Endocrinology 119:940.

    Article  PubMed  CAS  Google Scholar 

  • Tramontano, D., Rotella, C.M., Toccafondi, R., Ambesi-Impiombato, S.F., 1986c, Thyrotropin-independent mutant clones from FRTL-5 rat thyroid cells: hormonal control mechanisms in differentiated cells, Endocrinology 118:862.

    Article  PubMed  CAS  Google Scholar 

  • Tramontano, D., Moses, A.C., Ingbar, S.H., 1988a, The role of adenosine 3′,5′-monophosphate in the regulation of receptors for thyrotropin and insulin-like growth factor I in the FRTL-5 rat thyroid follicular cell, Endocrinology 122:133.

    Article  PubMed  CAS  Google Scholar 

  • Tramontano, D., Moses, A.C., Veneziani, B.M., Ingbar, S.H., 1988b, Adenosine 3′,5′-monophosphate mediates both the mitogenic effect of thyrotropin and its ability to amplify the response to insulin-like growth factor I in FRTL-5 cells, Endocrinology 122:127.

    Article  PubMed  CAS  Google Scholar 

  • Tsushima, T., Arai, M., Saji, M., Ohba, Y., Murakami, H., Ohmura, E., Sato, K., Shizume, K., 1988, Effects of transforming growth factor-ß on deoxyribonucleic acid synthesis and iodine metabolism in porcine thyroid cells in culture, Endocrinology 123:1187.

    Article  PubMed  CAS  Google Scholar 

  • Van Sande, J., Grenier, G., Willems, C., Dumont, J.E., 1975, Inhibition by iodide of the activation of the thyroid cyclic 3′,5′-AMP system, Endocrinology 96:781.

    Article  PubMed  Google Scholar 

  • Van Sande, J., Lefort, A., Beebe, S., Roger, P., Perret, J., Corbin, J., Dumont, J.E., 1989, Pairs of cyclic AMP analogs, that are specifically synergistic for type I and type II cAMP-dependent protein kinases, mimic thyrotropin effects on the function, differentiation expression and mitogenesis of dog thyroid cells, Eur. J. Biochem. 183:699.

    Article  PubMed  Google Scholar 

  • Westermark, K., Karlsson, F.A., Westermark, B., 1983, Epidermal growth factor modulates thyroid growth and function in culture, Endocrinology 112:1680.

    Article  PubMed  CAS  Google Scholar 

  • Westermark, K., Westermark, B., 1982, Mitogenic effect of epidermal growth factor on sheep thyroid cells in culture, Exp. Cell. Res. 138:47.

    Article  PubMed  CAS  Google Scholar 

  • Williams, D.W., Williams, E.D., Wyndford-Thomas, D., 1988, Loss of dependence on IGF-1 for proliferation of human thyroid adenoma cells, Br. J. Cancer 57:535.

    Article  PubMed  CAS  Google Scholar 

  • Wyllie, F.S., Dawson, T., Bond, J.A., Goretzki, P., Game, S., Prime, S., Wynford-Thomas, D., 1991, Correlated abnormalities of tansforming growth factor-β1 response and p53 expression in thyroid epithelial cell tansrormation, Mol. Cell. Endocrinol. 76:13.

    Article  PubMed  CAS  Google Scholar 

  • Yoshikawa, N., Nishikawa, M., Horimoto, M., Yoshimura, M., Sawaragi, S., Horikoshi, Y., Sawaragi, I., Inada, M., 1989, Thyroid-stimulating activity in sera of normal pregnant women, J. Clin. Endocrinol. Metab. 69:891.

    Article  PubMed  CAS  Google Scholar 

  • Yoshikawa, N., Nishikawa, M., Horimoto, M., Yoshimura, M., Toyoda, N., Inada, M., 1990, Human chorionic gonadotropin promotes thyroid growth via thyrotropin receptors in FRTL-5 cells, Endocrinol. Japon. 37:639.

    Article  CAS  Google Scholar 

  • Yoshimura, M., Nishikawa, M., Horimoto, M., Yoshikawa, N., Sawaragi, S., Horikoshi, Y., Sawaragi, I., Inada, M., 1990, Thyroid-stimulating activity of human chorionic gonadotropin in sera of normal pregnant women, Acta Endocrinol. 123:277.

    PubMed  CAS  Google Scholar 

  • Yoshimura, M., Nishikawa, M., Yoshikawa, N., Horimoto, M., Toyoda, N., Sawaragi, I., Inada, M., 1991, Mechanism of thyroid stimulation by human chorionic gonadotropin in sera of normal pregnant women, Acta Endocrinologica 124:173.

    PubMed  CAS  Google Scholar 

  • Zakarija, M., McKenzie, M.J., 1990, Do thyroid growth-promoting immunoglobulins exist?, J. Clin. Endocrinol. Metab. 70:308.

    Article  PubMed  CAS  Google Scholar 

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  1. Institut de Recherche Interdisciplinaire, Faculté de Médecine, Hôpital Erasme, Université Libre de Bruxelles, Campus Erasme, 808 route de Lennik, B-1070, Bruxelles, Belgium

    J. E. Dumont

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  1. University of Brussels, Brussels, Belgium

    F. Delange  & D. Glinoer  & 

  2. University of Virginia Health Sciences Center, Charlottesville, Virginia, USA

    J. T. Dunn

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Dumont, J.E. (1993). Control of Thryoid Growth. In: Delange, F., Dunn, J.T., Glinoer, D. (eds) Iodine Deficiency in Europe. NATO ASI Series, vol 241. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1245-9_4

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  • DOI: https://doi.org/10.1007/978-1-4899-1245-9_4

  • Publisher Name: Springer, Boston, MA

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