Abstract
Our knowledge of the genetics of insulin-dependent diabetes mellitus (IDDM), and in particular the HLA system, has gained considerable expansion due to the application of molecular biology. The genetic susceptibility to this disease is linked to the HLA region, particularly the DQ alpha and DQ beta chain genes. The presence of an amino acid other than aspartic acid in position 57 of the DQ beta chain and arginine in position 52 of the DQ alpha chain represent, to date, the best markers to identify subjects at-risk for developing IDDM. The identification of such subjects may be useful for strategies aimed at preventing the disease and may also offer new insight into population screening.
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© 1994 Springer Science+Business Media New York
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Buzzetti, R., Nisticò, L., Pozzilli, P., Giovannini, C. (1994). Analysis of HLA-DQ Alpha and DQ Beta Genes in Type I (Insulin-dependent) Diabetes. In: Dorman, J.S. (eds) Standardization of Epidemiologic Studies of Host Susceptibility. NATO ASI Series, vol 270. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1213-8_23
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DOI: https://doi.org/10.1007/978-1-4899-1213-8_23
Publisher Name: Springer, Boston, MA
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