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Standardization of Epidemiologic Studies of Host Susceptibility pp 77–82Cite as

HLA-DR3 and DR4 Allele Segregation in IDDM Families and in Controls

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Part of the book series: NATO ASI Series ((NSSA,volume 270))

Abstract

Segregation distortion of HLA alleles in IDDM families is still a matter of discussion. Some evidence for preferential transmission of DR3 and DR4 from parents to both diabetic and non-diabetic progenies has been given.1 However, other studies investigating the same issue have not confirmed this differential mode of inheritance.2

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References

  1. C.M. Vadheim, J.I. Rotter, N.K. Maclaren, W.J. Riley, C.E. Anderson, Preferential transmission of diabetic alleles within the HLA gene complex, N Eng J Med. 315:1314 (1986).

    Article  CAS  Google Scholar 

  2. J.M. Martin-Villa, J.L. Vicario, J. Martinez-Laso, M. Serrano-Rios, G. Lledo, A. Damiano, F. Hawkins, J.R. Regueiro, A. Arnaiz-Villena, Lack of preferential transmission of diabetic HLA alleles by healthy parents to offspring in Spanish diabetic families, J Clin Endocrinol Metab. 70:346 (1990).

    Article  PubMed  CAS  Google Scholar 

  3. P. Astolfi, M. Martinetti, F. Gigli-Berzolari, M. Cuccia, The effect of parental and maternal-fetal histocompatibility at MCH on sex ratio in offspring, Tissue Antigens 35:172 (1990).

    Article  PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Laboratorio HLA Servizio di Immunoematologia e Trasfusione, IRCCS Policlinico San Matteo, Pavia, Italy

    Cristina Daielli & Miryam Martinetti

  2. Dipartimento di Pediatria, Università degli Studi, Pavia, Italy

    Renata Lorini, Luisella Cortona, Letizia Vitali & Giuseppe d’Annunzio

  3. Dipartimento di Genetica e Microbiologia, Università degli Studi, Pavia, Italy

    Mariaclara Cuccia

  4. Dipartimento di Medicina Preventiva, Occupazionale e di Comunita Sezione di Igiene, Università degli Studi, Pavia, Italy

    Gabriele Devoti & Maria T. Tenconi

Authors
  1. Cristina Daielli
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  2. Renata Lorini
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  3. Miryam Martinetti
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  4. Luisella Cortona
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  5. Mariaclara Cuccia
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  6. Letizia Vitali
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  7. Gabriele Devoti
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  8. Giuseppe d’Annunzio
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  9. Maria T. Tenconi
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Editor information

Editors and Affiliations

  1. Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

    Janice S. Dorman

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© 1994 Springer Science+Business Media New York

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Daielli, C. et al. (1994). HLA-DR3 and DR4 Allele Segregation in IDDM Families and in Controls. In: Dorman, J.S. (eds) Standardization of Epidemiologic Studies of Host Susceptibility. NATO ASI Series, vol 270. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1213-8_12

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  • DOI: https://doi.org/10.1007/978-1-4899-1213-8_12

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-1215-2

  • Online ISBN: 978-1-4899-1213-8

  • eBook Packages: Springer Book Archive

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