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Immunopharmacology in Autoimmune Diseases and Transplantation pp 369–377Cite as

Mechanisms Involved in Immunomodulatory Treatment of Rheumatoid Arthritis

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Abstract

Many inflammatory rheumatic diseases, including rheumatoid arthritis, appear to depend on a dysregulation of the immune system, that is, interference with pathogenetically important immune reactions can be expected to have beneficial or even direct curative effects on the respective diseases. Ideally, an adequate therapy would thus require knowledge of which immune reactions are critical for disease development and access to means whereby these but no other reactions could be down-regulated. Even if we are far from this situation both as to pathogenetic knowledge and access of practically working specific immunomodulatory treatment, our emerging knowledge on the immunopathogenesis of rheumatic joint diseases may be used both to reconsider the mode of action of currently used drugs and to critically approach some of the more experimental treatments that have recently been introduced.

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Authors and Affiliations

  1. Department of Clinical Immunology, Uppsala University Hospital, S-751 85, Uppsala, Sweden

    Lars Klareskog

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  1. Lars Klareskog
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Editors and Affiliations

  1. Department of Clinical Pharmacology, The National Hospital, University of Oslo, N-0027, Oslo 1, Norway

    Hans Erik Rugstad

  2. Institute of Clinical Biochemistry, The National Hospital, University of Oslo, 0027, Oslo 1, Norway

    Liv Endresen

  3. Oslo Sanitetsforening Rheumatism Hospital, N-0172, Oslo 1, Norway

    Øystein Førre

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© 1992 Springer Science+Business Media New York

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Klareskog, L. (1992). Mechanisms Involved in Immunomodulatory Treatment of Rheumatoid Arthritis. In: Rugstad, H.E., Endresen, L., Førre, Ø. (eds) Immunopharmacology in Autoimmune Diseases and Transplantation. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1167-4_29

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  • DOI: https://doi.org/10.1007/978-1-4899-1167-4_29

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-1169-8

  • Online ISBN: 978-1-4899-1167-4

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