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Immunopharmacology in Autoimmune Diseases and Transplantation pp 301–311Cite as

Insulin-Dependent Diabetes Mellitus

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Abstract

In insulin-dependent diabetes mellitus (IDDM), or type 1 diabetes, there is selective loss of the beta cells of the pancreas. This leads to insulinopenia, ketosis, and the need for exogenous insulin to sustain life. Although IDDM can occur at any age, it usually arises in the young and as a result is among the most common, major chronic pediatric diseases in the Western world. In Canada, the annual incidence is approximately 9 new cases/100,000 in those under 19 years of age (Ehrlich et al., 1982). Despite provision of parenteral insulin, chronic IDDM is associated with undue morbidity, including micro- and macrovasculopathy and neuropathy (Kolb and Nerup, 1985) and premature mortality (Borch-Johnsen et al., 1986). This has led to a search into the fundamental causes of the disease with the hope of developing curative treatment—in distinction to the existing, problematic one of substitution.

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Authors and Affiliations

  1. University Hospital, The University of Western Ontario, London, Ontario, N6A 5A5, Canada

    J. L. Mahon, J. Dupre & C. R. Stiller

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  1. J. L. Mahon
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  2. J. Dupre
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  3. C. R. Stiller
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Editors and Affiliations

  1. Department of Clinical Pharmacology, The National Hospital, University of Oslo, N-0027, Oslo 1, Norway

    Hans Erik Rugstad

  2. Institute of Clinical Biochemistry, The National Hospital, University of Oslo, 0027, Oslo 1, Norway

    Liv Endresen

  3. Oslo Sanitetsforening Rheumatism Hospital, N-0172, Oslo 1, Norway

    Øystein Førre

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Mahon, J.L., Dupre, J., Stiller, C.R. (1992). Insulin-Dependent Diabetes Mellitus. In: Rugstad, H.E., Endresen, L., Førre, Ø. (eds) Immunopharmacology in Autoimmune Diseases and Transplantation. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1167-4_23

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  • DOI: https://doi.org/10.1007/978-1-4899-1167-4_23

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-1169-8

  • Online ISBN: 978-1-4899-1167-4

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