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Vaccines against Human Papillomaviruses and Associated Tumors

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DNA Tumor Viruses

Part of the book series: Infectious Agents and Pathogenesis ((IAPA))

Abstract

In principle there is no reason why vaccination against human papillomavirus (HPV) infection and against HPV-associated tumors should not already be in progress. Systems for production of the necessary antigens have been available for some time, and the problems of producing papillomavirus-coded proteins in adequate amounts and of acceptable quality have largely been overcome. For a long time the fact that HPVs could not be grown in vitro, and that virus particles from in vivo lesions were available at only very low levels, ruled out vaccination against the initial virus infection. By the use of recombinant DNA technology, components of the virus particle and, more recently, synthetic empty virus particles with many of the properties of authentic virus particles have been produced. These are discussed under prophylactic vaccines.

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Author information

Authors and Affiliations

  1. ICRF Tumour Virus Group, Department of Pathology, University of Cambridge, Cambridge, CB2 1QP, England

    Lionel Crawford

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  1. Lionel Crawford
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Editors and Affiliations

  1. Institute of Microbiology, School of Medicine, University of Ferrara, I-44100, Ferrara, Italy

    Giuseppe Barbanti-Brodano

  2. University of Pisa, Pisa, Italy

    Mauro Bendinelli

  3. University of South Florida, Tampa, Florida, USA

    Herman Friedman

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© 1995 Springer Science+Business Media New York

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Crawford, L. (1995). Vaccines against Human Papillomaviruses and Associated Tumors. In: Barbanti-Brodano, G., Bendinelli, M., Friedman, H. (eds) DNA Tumor Viruses. Infectious Agents and Pathogenesis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1100-1_9

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  • DOI: https://doi.org/10.1007/978-1-4899-1100-1_9

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-1102-5

  • Online ISBN: 978-1-4899-1100-1

  • eBook Packages: Springer Book Archive

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