Abstract
In recent years it has become increasingly apparent that carcinogenesis is a multistage process requiring the cooperation of several cofactors. The predictions of Nordling(1) and Armitage and Doll(2) that six or seven successive changes occur during progression to carcinoma have now been confirmed, most notably in the instance of colorectal cancer with the demonstration that mutations of several defined protooncogenes and tumor suppressor genes accumulate during the transition from normal colonic epithelium to carcinoma.(3) Studies in in vitro transformation have also demonstrated that the introduction of more than one oncogene into normal diploid cells is required for the acquisition of a malignant phenotype.(4–6) The identification of both genetic predispositions and environmental factors that contribute to the process of carcinogenesis is a major goal of cancer research. In some cases the agents that cooperate in the induction of naturally occurring cancer have been identified. Thus, papillomavirus infection and the presence of bracken fern in the diet have been demonstrated to elicit both alimentary canal and urinary bladder cancers in cattle. This chapter reviews the evidence for cooperation between viruses and chemicals in the bovine system and our current understanding of how these factors interact in oncogenesis.
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Jackson, M.E., Campo, M.S. (1995). Cooperation between Bovine Papillomaviruses and Dietary Carcinogens in Cancers of Cattle. In: Barbanti-Brodano, G., Bendinelli, M., Friedman, H. (eds) DNA Tumor Viruses. Infectious Agents and Pathogenesis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1100-1_7
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