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Immortalization of Keratinocytes by Human Papillomaviruses

  • Chapter
DNA Tumor Viruses

Part of the book series: Infectious Agents and Pathogenesis ((IAPA))

Abstract

Human papillomaviruses (HPVs) have a unique position in viral carcinogenesis studies. They are ubiquitous, cause chronic infection, and are well adapted to the host immune system. In 1907, Ciuffo demonstrated that the infectious agent for the common wart persisted in filtered homogenates and, thus, clearly established that it was not either a bacterium or protozoan.(1) Subsequently, it was determined that common warts are associated with HPV-1 and -2. Analysis of the genetic drift of HPV-16, the most common HPV associated with cervical cancer, suggests that the viruses evolved slowly.(2) Presently, there are more than 100 types of HPV, including more than 65 that have been characterized and partially cloned.(3) The uniqueness of HPV and nonhuman papillomaviruses (PV) is that animal viruses do not infect humans, and vice versa; thus, there is species specificity. In addition, tissue tropism exists. Thus, a specific HPV type is associated with a specific anatomic site of infection. The cell biology and pathogenesis of different HPV infections has recently been reviewed.(4,5)

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Authors and Affiliations

  1. National Cancer Institute, Laboratory of Biology, Bethesda, Maryland, 20892, USA

    Craig D. Woodworth & Joseph A. DiPaolo

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  1. Craig D. Woodworth
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  2. Joseph A. DiPaolo
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  1. Institute of Microbiology, School of Medicine, University of Ferrara, I-44100, Ferrara, Italy

    Giuseppe Barbanti-Brodano

  2. University of Pisa, Pisa, Italy

    Mauro Bendinelli

  3. University of South Florida, Tampa, Florida, USA

    Herman Friedman

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Woodworth, C.D., DiPaolo, J.A. (1995). Immortalization of Keratinocytes by Human Papillomaviruses. In: Barbanti-Brodano, G., Bendinelli, M., Friedman, H. (eds) DNA Tumor Viruses. Infectious Agents and Pathogenesis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1100-1_6

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  • DOI: https://doi.org/10.1007/978-1-4899-1100-1_6

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