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Current Developments in the Molecular Biology of Marek’s Disease Virus

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Abstract

Marek’s disease virus (MDV) is an avian herpesvirus that induces lymphoproliferative disease in chicken, its natural host.(1,2) The MDV once was a threat to the poultry industry because of the great economic damage caused by destruction of chicken flocks by infection. However, in the 1970s, vaccination of chickens by use of the nononcogenic MDV serotype II or serotype III (herpesvirus of turkey, HVT) or by attenuated serotype I strain of oncogenic MDV effectively prevented the spread of Marek’s disease (MD) in chicken flocks. Although vaccination solved much of the problem caused by MDV-induced disease, vaccine breaks still occur, and economic loss to the poultry industry currently amounts to over $100 million annually.(3)

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  1. Tampa Bay Research Institute, St. Petersburg, Florida, 33716, USA

    Meihan Nonoyama & Akiko Tanaka

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  1. Meihan Nonoyama
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  1. Institute of Microbiology, School of Medicine, University of Ferrara, I-44100, Ferrara, Italy

    Giuseppe Barbanti-Brodano

  2. University of Pisa, Pisa, Italy

    Mauro Bendinelli

  3. University of South Florida, Tampa, Florida, USA

    Herman Friedman

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Nonoyama, M., Tanaka, A. (1995). Current Developments in the Molecular Biology of Marek’s Disease Virus. In: Barbanti-Brodano, G., Bendinelli, M., Friedman, H. (eds) DNA Tumor Viruses. Infectious Agents and Pathogenesis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1100-1_12

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