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The Complex Role of Hepatitis B Virus in Human Hepatocarcinogenesis

  • Chapter
DNA Tumor Viruses

Part of the book series: Infectious Agents and Pathogenesis ((IAPA))

Abstract

Viral hepatitis in humans has been causally related to a variety of agents, which belong to different virus groups and differ markedly in their structural and biological properties. As many as five viruses associated with human hepatitis (the hepatitis A, B, C, D, and E viruses) have been isolated and fully characterized,(1–5) and the question of whether additional, uncharacterized viruses may be responsible for liver disease in some cases is still debated. Among the known human hepatitis viruses, two—the hepatitis B and C viruses—appear to be more pathogenic for humans because of their ability to induce persistent infections in the infected host. Chronic, long-lasting infections with both agents frequently result in the development of liver cirrhosis and ultimately evolve to primary liver cancer in a significant proportion of virus carriers.

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Authors and Affiliations

  1. Département des Rétrovirus, Institut Pasteur, Unité de Recombinaison et Expression Génétique, INSERM U163, 75724, Paris Cedex 15, France

    Marie Annick Buendia & Pascal Pineau

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  1. Marie Annick Buendia
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  2. Pascal Pineau
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  1. Institute of Microbiology, School of Medicine, University of Ferrara, I-44100, Ferrara, Italy

    Giuseppe Barbanti-Brodano

  2. University of Pisa, Pisa, Italy

    Mauro Bendinelli

  3. University of South Florida, Tampa, Florida, USA

    Herman Friedman

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Buendia, M.A., Pineau, P. (1995). The Complex Role of Hepatitis B Virus in Human Hepatocarcinogenesis. In: Barbanti-Brodano, G., Bendinelli, M., Friedman, H. (eds) DNA Tumor Viruses. Infectious Agents and Pathogenesis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1100-1_10

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