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Part of the book series: Infectious Agents and Pathogenesis ((IAPA))

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Abstract

The syndrome of Legionnaires’ disease was first recognized at the 1976 American Legion Convention in Philadelphia where 221 Legionnaires contracted pneumonia and 34 died. The causative agent was identified as an aerobic gramnegative bacterium, subsequently named Legionella pneumophila. 1 Although the family Legionellaceae comprises more than 40 species, L. pneumophila remains the most common species implicated in human disease and therefore will be the focus of this discussion.

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References

  1. Fraser, D. W., Tsai, T., Orenstein, W., Parkins, W. E., Beecham, H. J., Sharrar, R. G., Harris, J., Mallison, G. F., Martin, S. M., McDade, J. E., Shepard, C. C., and Brachman, P. S., 1977, Legionnaires’ disease: Description of an epidemic of pneumonia, N. Engl. J. Med. 297:1183–1197.

    Article  Google Scholar 

  2. Stout, J. E., Yu, V. L., and Best, M., 1985, Ecology of Legionella pneumophila within water distribution systems, Appl. Environ. Microbiol. 49:221–228.

    PubMed  CAS  Google Scholar 

  3. Wadowsky, R. M., Wolford, R., McNamara, A. M., and Yee, R. B., 1985, Effect of temperature, pH, and oxygen level on the multiplication of naturally occurring Legionella pneumophila in potable water, Appl. Environ. Microbiol. 49:1197–1205.

    PubMed  CAS  Google Scholar 

  4. Tison, D. L., Pope, D. H., Cherry, W. B., and Fliermans, E., 1980, Growth of Legionella pneumophila in association with blue-green algae (cyanobacteria), Appl. Environ. Microbiol. 39:456–459.

    PubMed  CAS  Google Scholar 

  5. Fields, B. S., Shotts, E. B., Feeley, J. C., Gorman, G. W., and Martin, W. T., 1984, Proliferation of Legionella pneumophila as an intracellular parasite of the ciliated protozoan Tetrahymena pyriformis, Appl. Environ. Microbiol. 47:467–471.

    PubMed  CAS  Google Scholar 

  6. Rowbotham, T. J., 1986, Current views on the relationships between amoebae, Legionellae, and man, Isr. J. Med. Sci. 22:678–689.

    PubMed  CAS  Google Scholar 

  7. Yamamoto, Y., Klein, T. W., Newton, C., and Friedman, H., 1992, Differing macrophage and lymphocyte roles in resistance to Legionella pneumophila infection, J.Immunol. 148:584–589.

    PubMed  CAS  Google Scholar 

  8. Aeba, R., Stout, J. E., Francalancia, N. A., Keenan, R. J., Duncan, A. J., Yousem, S. A., Burckart, G. J., Yu, V. L., and Griffith, B. P., 1993, Aspects of lung transplantation which contribute to increased severity of pneumonia: An experimental study, J. Thoracic Cardio-vasc. Surg. 106:449–457.

    CAS  Google Scholar 

  9. Brady, M., 1989, Nosocomial Legionnaires’ disease in a children’s hospital, J. Pediatr. 115:46–50.

    Article  PubMed  CAS  Google Scholar 

  10. Hervas, J., Lopez, P., de la Fuente, A., and Alomar, P., 1988, Multiple organ system failure in an infant with Legionella infection, Pediatr. Infect. Dis. J. 7:671–673.

    Article  PubMed  CAS  Google Scholar 

  11. Muder, R. R., Yu, V. L., and Woo, A., 1986, Mode of transmission of L. pneumophila: A critical review, Arch. Int. Med. 146:1607–1612.

    Article  CAS  Google Scholar 

  12. Yu, V. L., and Stout, J. E., 1992, Sporadic cases of Legionnaires’ disease, N. Engl. J. Med. 326:1700–1701.

    Google Scholar 

  13. Stout, J. E., Yu, V. L., Vickers, R. M., Zuravleff, J., Best, M., Brown, A., Yee, R. B., and Wadowsky, R., 1982, Ubiquitousness of Legionella pneumophila in the water supply of a hospital with endemic Legionnaires’ disease, N. Engl. J. Med. 306:466–468.

    Article  PubMed  CAS  Google Scholar 

  14. Markowitz, L., Tompkins, L., Wilkinson, H., Barbaree, J., and Broome, C. V., 1984, Transmission of nosocomial Legionnaires’ disease in heart transplant patients, Program and Abstracts of the 24th Intersci. Conf. Antimicrob. Ag. Chemother., Amer. Soc. Microbiol., Washington DC. 170 (abstract).

    Google Scholar 

  15. Woo, A. H., Goetz, A., and Yu, V. L., 1992, Transmission of Legionella by respiratory equipment and aerosol generating devices: A review, Chest 102:1586–1590.

    Article  PubMed  CAS  Google Scholar 

  16. Muder, R. R., Stout, J. E., and Yee, J. C., 1992, Isolation of Legionella pneumophila sero-group 5 from empyema following esophageal perforation: source of the organism and mode of transmission, Chest 102:1601–1603.

    Article  PubMed  CAS  Google Scholar 

  17. Yu, V. L., Stout, J., Zuravleff, J., and Brown, A., 1981, Aspiration of contaminated water may be mode of transmission for Legionella pneumophila just prior to a nosocomial outbreak of Legionnaires’ disease, Intersci. Conf. Antimicrob. Ag. Chemother., #293, Chicago.

    Google Scholar 

  18. Marrie, T. J., Haldane, D., MacDonald, S., Clarke, K., Fanning, C., Lefort-Jost, S., Bezanson, G., and Joly, J., 1991, Control of endemic nosocomial Legionnaires’ disease by using sterile potable water for high risk patients, Epidemiol. Infect. 107:591–605.

    Article  PubMed  CAS  Google Scholar 

  19. Glick, T. H., Gregg, M. B., Berman, B., Mallison, G., Rhodes, W. W., Jr., and Kassanoff, I., 1978, Pontiac fever: An epidemic of unknown etiology in a health department: Clinical and epidemiologic aspects, Am. J. Epidemiol. 149–160.

    Google Scholar 

  20. Arnow, P., Chou, T., Weil, D., Shapiro, E., et al., 1982, Nosocomial Legionnaires; disease caused by aerosolized tap water from respiratory devices, J.Infect. Dis. 146:460–67.

    Article  PubMed  CAS  Google Scholar 

  21. Kaan, J., Simoons-Smith, A. M., and MacLaren, D., 1985, Another source of aerosol causing nosocomial Legionnaires’ disease, J.Inf. 11:145–148.

    Article  CAS  Google Scholar 

  22. Mastro, T. D., Fields, B. S., Breiman, R. F., Campbell, J., Plikaytis, D., and Spika, J. S., 1991, Nosocomial Legionnaires’ disease and use of medication nebulizers, J. Infect. Dis. 163: 667–671.

    Article  PubMed  CAS  Google Scholar 

  23. Wright, J. B., Athar, M. A., van Olm, T. M., Wootliff, J. S., and Costerton, J. S., 1989, Atypical legionellosis: Isolation of Legionella pneumophila serogroup 1 from a patient with aspiration pneumonia, J. Hosp. Infect. 13:187–190.

    Article  PubMed  CAS  Google Scholar 

  24. Blatt, S. P., Parkinson, M. D., Pace, E., et al., 1992, Nosocomial Legionellosis: A one year case-control and environmental investigation, International Symposium on Legionella, III-6 (abstract), Am. Soc. Microbiol., Orlando, Florida.

    Google Scholar 

  25. Johnson, J. T., Yu, V. L., Best, M., Vickers, R. M., et al., 1985, Nosocomial legionellosis uncovered in surgical patients with head and neck cancer: Implications for epidemiologic reservoir and mode of transmission, Lancet 2:298–300.

    Article  PubMed  CAS  Google Scholar 

  26. Davis, G. S., Winn, W., Gump, D. W., and Beaty, H., 1983, The kinetics of early inflammatory events during experimental pneumonia due to Legionella pneumophila in guinea pigs, J. Infect. Dis. 148:823–835.

    Article  PubMed  CAS  Google Scholar 

  27. Horwitz, M. A., and Silverstein, S. C., 1980, The Legionnaires’ disease bacterium (Legionella pneumophila) multiples intracellularly in human monocytes, J. Clin. Invest. 66:441–450.

    Article  PubMed  CAS  Google Scholar 

  28. Horwitz, M. A., and Silverstein, S. C., 1981, Interaction of the Legionnaires’ disease bacterium (Legionella pneumophila) with human phagocytes: II Antibody promotes binding of L. pneumophila, J. Exp. Med. 153:398–406.

    Article  PubMed  CAS  Google Scholar 

  29. Nash, T. W., Libby, D., and Horwitz, M. A., 1984, Interaction between the Legionnaires’ disease bacterium (L. pneumophila) and human alveolar macrophages: Influence of antibody, lymphokines, and hydrocortisone, J. Clin. Invest. 74:771–782.

    Article  PubMed  CAS  Google Scholar 

  30. Horwitz, M. A., 1984, Phagocytosis of the Legionnaires’ disease bacterium (Legionella pneumophila) occurs by a novel mechanism: Engulfment within a pseudopod coil, Cell 36:27–33.

    Article  PubMed  CAS  Google Scholar 

  31. Payne, N. R., and Horwitz, M. A., 1987, Phagocytosis of Legionella pneumophila is mediated by human monocyte complement receptors, J. Exp. Med. 166:1377–1389.

    Article  PubMed  CAS  Google Scholar 

  32. King, C. H., Fields, B. S., Shotts, E. B., Jr., and White, E. H., 1991, Effects of cytochalasin D and methylamine on intracellular growth of Legionella pneumophila in amoebae and human monocyte-like cells, Infect. Immun. 59:758–763.

    PubMed  CAS  Google Scholar 

  33. Holden, E. P., Winkler, H. H., Wood, D. O., and Leinbach, E. D., 1984, Intracellular growth of Legionella pneumophila within Acanthamoeba castellanii neff, Infect. Immun. 45:18–24.

    PubMed  CAS  Google Scholar 

  34. Newsome, A. L., Baker, R. L., Miller, R. D., and Arnold, R. R., 1985, Interactions between Naelglaria fowleri and Legionella pneumophila, Infect. Immun. 50:449–542.

    PubMed  CAS  Google Scholar 

  35. Tyndall, R. L., and Domingue, E. L., 1982, Cocultivation of Legionella pneumophila and free-living amoebae, Appl. Environ. Microbiol. 44:954–959.

    PubMed  CAS  Google Scholar 

  36. Rolstad, B., and Berdal, B., 1981, Immune defenses against Legionella pneumophila in rats, Infect. Immun. 32:805–812.

    PubMed  CAS  Google Scholar 

  37. Breiman, R. F., and Horwitz, M. A., 1987, Guinea pigs sublethally infected with aerosolized Legionella pneumophila develop humoral and cell-mediated immune responses, J.Exp. Med. 164:799–811.

    Article  Google Scholar 

  38. Davis, G. S., Winn, W., and Christman, J. W., 1989, Role of recruited nonimmunospecific defenses in Legionnaires’ disease, Chest 95:232S–233S.

    Article  Google Scholar 

  39. Bellinger-Kawahara, C. G., and Horwitz, M. A., 1987, The major outer protein is a prominent acceptor molecule for complement component C3 on Legionella pneumophila, Clin. Res. 35.–468A.

    Google Scholar 

  40. Locksley, R. M., Jacobs, R. F., Wilson, C. B., Weaver, W. M., and Klebanoff, S. J., 1982, Susceptibility of Legionella pneumophila to oxygen-dependent microbial systems, J.Immunol. 2192–2197.

    Google Scholar 

  41. Lochner, J. E., Friedman, R. L., Bigley, R. H., and Iglewski, B. H., 1983, Effect of oxygen-dependent antimicrobial systems on Legionella pneumophila, Infect. Immun. 39:487–489.

    PubMed  CAS  Google Scholar 

  42. Summersgill, J. T., Raff, M. J., Miller, R. D., 1988, Interactions of virulent and avirulent Legionella pneumophila with human polymorphonuclear leukocytes, Microbiol. Pathogen. 5:41–47.

    Article  CAS  Google Scholar 

  43. Skerrett, S. J., and Martin, T. R., 1991, Alveolar macrophage activation in experimental legionellosis, J.Immunol. 147:337–345.

    PubMed  CAS  Google Scholar 

  44. Byrd, T. F., and Horwitz, M. A., 1989, Interferon gamma-activated human monocytes downregulate transferrin receptors and inhibit the intracellular multiplication of Legionella pneumophila by limiting the availability of iron, J.Clin. Invest. 83:1457–1465.

    Article  PubMed  CAS  Google Scholar 

  45. Bhardwaj, N., Nash, T., and Horwitz, M. A., 1986, Interferon-gamma-activated human monocytes inhibit the intracellular multiplication of L. pneumophila,J. Immunol. 137:2662–2669.

    PubMed  CAS  Google Scholar 

  46. Jensen, W. A., Rose, R. M., Wasserman, A. S., Kalb, T. H., Anton, K., and Remold, H. G., 1987, In vitro activation of the antibacterial activity of human pulmonary macrophages by recombinant gamma interferon, J. Infect. Dis. 155:574–577.

    Article  PubMed  CAS  Google Scholar 

  47. Goldoni, P., Visca, P., Pastoris, M. C., Valenti, P., and Orsi, N., 1991, Growth of Legionella spp. under conditions of iron restriction, J. Med. Microbiol. 34:113–118.

    Article  PubMed  CAS  Google Scholar 

  48. Yammamoto, Y., Klein, T. W., Newton, C. A., Widen, R., and Friedman, H., 1987, Differential growth of Legionella pneumophila in guinea pig versus mouse macrophage cultures, Infect. Immun. 55:1369–1374.

    Google Scholar 

  49. Yoshida, S. I., and Mizuguchi, Y., 1986, Multiplication of Legionella pneumophila Philadelphia-1 in cultured peritoneal macrophages and its correlation to susceptibility of animals, Can. J. Microbiol. 32:438–442.

    Article  PubMed  CAS  Google Scholar 

  50. Berendt, R. F., Young, H. W., Allen, R. G., and Knutsen, G. L., 1980, Dose-response of guinea pigs experimentally infected with aerosols of Legionella pneumophila, J. Infect. Dis. 141:186–192.

    Article  PubMed  CAS  Google Scholar 

  51. Davis, G. S., Winn, W. C., Gump, D. W., and Craighead, J. E., 1982, Legionnaires’ pneumonia after aerosol exposure in guinea pigs and rats, Am. Rev. Respir. Dis. 126:1050–1057.

    PubMed  CAS  Google Scholar 

  52. Skerrett, S. J., Schmidt, R., and Martin, T. R., 1989, Impaired clearance of aerosolized L. pneumophila in corticosteroid treated rats: A model of Legionnaire’s disease in the compromised host, J. Infect. Dis. 160:261–268.

    Article  PubMed  CAS  Google Scholar 

  53. Yamamoto, Y., Klein, T. W., Newton, C. A., Widen, R., and Friedman, H., 1988, Growth of Legionella pneumophila in thioglycolate-elicited peritoneal macrophages from A/J mice, Infect. Immun. 56:370–375.

    PubMed  CAS  Google Scholar 

  54. Kishimoto, R. A., Kastello, M. D., White, J. D., Shirey, F. G., McGann, V. G., Larson, E. W., and Hedlung, K. W., 1979, In vitro interaction between normal cynomolgus monkey alveolar macrophages and Legionnaires’ disease bacteria, Infect. Immun. 25:761–763.

    PubMed  CAS  Google Scholar 

  55. Yamamoto, Y., Klein, T. W., Newton, C., and Freidman, H., 1992, Differing macrophage and lymphocyte roles in resistance to Legionella pneumophila infection, J. Immunol. 148: 584–589.

    PubMed  CAS  Google Scholar 

  56. Plouffe, J. F., and Baird, I. M., 1982, Cord blood lymphocyte transformation responses or L. pneumophila, Immunol. 9:119–120.

    CAS  Google Scholar 

  57. Friedman, H., Widen, R., Lee, I., and Klein, T., 1983, Cellular immunity to L. pneumophila in guinea pigs assessed by direct and indirect migration inhibition: reaction in vitro, Infec. Immun. 41:1132–1137.

    CAS  Google Scholar 

  58. Friedman, H., Widen, R., Klein, T., Searles, L., and Cabrian, K., 1984, L. pneumophila-induced blastogenesis of murine lymphoid cells in vitro, Infect. Immun. 43:314–319.

    PubMed  CAS  Google Scholar 

  59. Wong, K. H., McMaster, P. R. B., Feeley, J. C., Arko, R. J., Scalla, W.O., and Chandler, F. W., 1980, Detection of hypersensitivity to L. pneumophila in guinea pigs by skin test, Curr. Microbiol. 4:105–110.

    Article  Google Scholar 

  60. Nikaido, Y., Yoshida, S., Goto, Y., Mizuguchi, Y., and Kuroiwa, A., 1989, Macrophage-activating T-cell factor(s) produced in an early phase of Legionella pneumophila infection in guinea pigs, Infect. Immun. 57:3458–3465.

    PubMed  CAS  Google Scholar 

  61. Horwitz, M. A., 1983, Cell-mediated immunity in Legionnaires’ disease, J. Clin. Invest. 71:1686–1697.

    Article  PubMed  CAS  Google Scholar 

  62. Blanchard, D. K., Klein, T. W., Friedman, H., and Stewart, W. E., 1985, Kinetics and characterization of interferon production by murine spleen cells stimulated with Legionella pneumophila antigens, Infect. Immunity. 49:719–723.

    CAS  Google Scholar 

  63. Blanchard, D. K., Stewart, W.E., Klein, T. W., Friedman, H., and Djeu, J. Y., 1987, Cytolytic activity of human peripheral blood leukocytes against Legionella pneumophila-infected monocytes: Characterization of the effector, J.Immunol. 139:551–556.

    PubMed  CAS  Google Scholar 

  64. Klein, T. W., Newton, C. A., Blanchard, K., Widen, R., and Friedman, H., 1987, Induction of interleukin 1 by Legionella pneumophila antigens in mouse and human mononuclear leukocyte cultures, Zbl. Bakt. Hyg. A 265:462–471.

    CAS  Google Scholar 

  65. Nash, T. W., Libby, D. M., and Horwitz, M. A., 1988, IFN-gamma-activated human alveolar macrophages inhibit the intracellular multiplication of Legionella pneumophila, J. Immunol. 140:3978–3981.

    PubMed  CAS  Google Scholar 

  66. Gibson, D., Baskerville, A., Ashworth, L., and Fitzgeorge, R. B., 1985, Non-specific protection against pulmonary L. pneumophila infection in guinea pigs immunized and challenged with mycobacteria, Br. J. Exp. Pathol. 66:333–344.

    PubMed  CAS  Google Scholar 

  67. Horwitz, M. A., Lewis, W., and Cohn, Z. A., 1984, Defective production of monocyte-activating cytokines in lepromatous leprosy, J. Exp. Med. 159:666–678.

    Article  PubMed  CAS  Google Scholar 

  68. Blanchard, D. K., Djeu, J. Y., Klein, T. W., Friedman, H., and Stewart, W. E., II., 1988, Protective effects of tumor necrosis factor in experimental Legionella pneumophila infections of mice via activation of PMN function, J.Leuk. Biol. 43:429–435.

    CAS  Google Scholar 

  69. Blanchard, D. I., Friedman, H., Klein, T. W., and Djen, J. Y., 1989, Induction of interferon-gamma and tumor necrosis factor by Legionella pneumophila: Augmentation of human neutrophil bactericidal activity, J.Leuk. Biol. 45:538–545.

    CAS  Google Scholar 

  70. Caparon, M., and Johnson, W., 1988, Macrophage toxicity and complement sensitivity of virulent and avirulent strains of Legionella pneumophila, Rev. Infect. Dis. 10:S377–384.

    Article  Google Scholar 

  71. Jepras, R. I., and Fitzgeorge, R. B., 1986, The effect of oxygen-dependent antimicrobial systems on strains of Legionella pneumophila of different virulence, J. Hyg. (London) 97: 61–69.

    Article  PubMed  CAS  Google Scholar 

  72. Brown, A., Vickers, R. M., Elder, E. M., et al., 1982, Plasmid and surface antigen markers of endemic and epidemic Legionella pneumophila strains, J. Clin. Microbiol. 16:230–235.

    PubMed  CAS  Google Scholar 

  73. Maher, W. E., Plouffe, J. F., and Para, M. F., 1983, Plasmid profiles of clinical and environmental isolates of Legionella pneumophila serogroup 1, J.Clin. Microbiol. 18:1422–1423.

    PubMed  CAS  Google Scholar 

  74. Horwitz, M. A., 1987, Characterization of avirulent mutant Legionella pneumophila that survive but do not multiply within human monocytes, J.Exp. Med. 166:1310–1328.

    Article  PubMed  CAS  Google Scholar 

  75. McCusker, K. T., Braaten, B. A., Cho, M. W., and Low, D. A., 1991, Legionella pneumophila inhibits protein synthesis in Chinese hamster ovary cells, Infect. Immun. 59:240–246.

    PubMed  CAS  Google Scholar 

  76. Dennis, P. J., and Lee, J. V., 1988, Differences in aerosol survival between pathogenic and non-pathogenic strains of Legionella pneumophila serogroup 1, J. Appl. Bacteriol. 65:135–141.

    Article  PubMed  CAS  Google Scholar 

  77. Fields, B. S., Barbaree, J. M., Sanden, G. N., and Morrill, W. E., 1990, Virulence of a Legionella anisa strain associated with Pontiac fever: An evaluation using protozoan, cell culture, and guinea pig models, Infect. Immun. 58:3139–3142.

    PubMed  CAS  Google Scholar 

  78. Fields, B. S., Barbaree, J. M., Shotts, E., Feeley, J. C., Morill, W. E., Sanden, G. N., and Dykstra, M. J., 1986, Comparison of guinea pig and protozoan models for determining virulence of Legionella species, Infect. Immun. 53:553–559.

    PubMed  CAS  Google Scholar 

  79. Dournon, E., Bibb, W. F., Rajagopalan, P., Desplaces, N., and McKinney, R. M., 1988, Monoclonal antibody reactivity as a virulence marker for Legionella pneumophila serogroup 1 strains, J.Infect. Dis. 157:496–501.

    Article  PubMed  CAS  Google Scholar 

  80. Plouffe, J. F., Para, M. F., Maher, W. E., Hackman, B., and Webster, L., 1983, Subtypes of Legionella pneumophila serogroup 1 associated with different attack rates, Lancet 2:649–650.

    Article  PubMed  CAS  Google Scholar 

  81. Stout, J. E., Joly, J., Para, M., Plouffe, J., Ciesielski, C., Blaser, M. J., and Yu, V. L., 1988, Comparison of molecular methods for subtyping patients and epidemiologically-linked environmental isolates of L. pneumophila, J. Infect. Dis. 157:486–494.

    Article  PubMed  CAS  Google Scholar 

  82. Keen, M. G., and Hoffman, P. S., 1989, Characterization of a Legionella pneumophila extracellular protease exhibiting hemolytic and cytotoxic activities, Infect. Immun. 57:732–738.

    PubMed  CAS  Google Scholar 

  83. Baskerville, A., Conlan, J. W., Ashworth, L. A., and Dowsett, A. B., 1986, Pulmonary damage caused by a protease from L. pneumophila, Br. J. Exp. Pathol. 67:527–536.

    PubMed  CAS  Google Scholar 

  84. Conlan, J. W., Williams, A., and Ashworth, L. A. E., In vivo production of a tissue-destructive protease by Legionella pneumophila, J. Gen. Microbiol. 134:143–149.

    Google Scholar 

  85. Quinn, F. D., and Tompkins, L. S., Analysis of a cloned sequence of Legionella pneumophila encoding a 38 kD metalloprotease possessing haemolytic and cytotoxic activities, Mol. Microbiol. 3:797–805.

    Google Scholar 

  86. Dreyfus, L. A., and Iglewski, B. H., 1986, Purification and characterization of an extracellular protease of Legionella pneumophila, Infect. Immun. 51:736–743.

    PubMed  CAS  Google Scholar 

  87. Black, W. J., Quinn, F. D., and Tompkins, L. S., 1990, Legionella pneumophila zinc metalloprotease is structurally and functionally homologous to Pseudomonas aeruginosa elastase, J. Bacteriol. 172:2608–2613.

    PubMed  CAS  Google Scholar 

  88. Blander, S. J., Breiman, R., and Horwitz, M. A., A live avirulent mutant L. pneumophila vaccine induces protective immunity against lethal aerosol challenge, J. Clin. Invest. 83: 810–815.

    Google Scholar 

  89. Blander, S., and Horwitz, M.A., 1989, Vaccination with the major secretory protein of L. pneumophila induces cell-mediated immunity in a guinea pig model of Legionnaires’ disease, J. Exp. Med. 100:691–705.

    Article  Google Scholar 

  90. Szeto, L., and Shuman, H. A., 1990, The Legionella pneumophila major secretory protein, a protease, is not required for intracellular growth or cell killing, Infect. Immun. 58:2585–2592.

    PubMed  CAS  Google Scholar 

  91. Hacker, J., Ott, M., Ludwig, B., and Rdest, U., 1991, Intracellular survival and expression of virulence determinants of Legionella pneumophila, Infection (Suppl 4) 19:198–201.

    Article  Google Scholar 

  92. Wintermeyer, E., Rdest, U., Ludwig, B., Debes, A., and Hacker, J., 1991, Characterization of legiolysin(lly), responsible for haemolytic activity, colour production and fluorescence of Legionella pneumophila, Mol. Microbiol. 5(5):1135–1143.

    Article  PubMed  CAS  Google Scholar 

  93. Miragliotta, G., and Fumarola, D., 1989, Production of procoagulant activity, tissue factorlike, by human mononuclear cells and its role in the pathogenesis of Legionella prosthetic valve endocarditis, Medical Hypotheses 30:73–74.

    Article  PubMed  CAS  Google Scholar 

  94. Miragliotta, G., Semeraro, N., Marcuccio, L., and Fumarola, D., 1982, Legionella pneumophila and related organisms induce the generation of procoagulant activity by peripheral mononuclear cells in vitro, Infection 10:215.

    Article  PubMed  CAS  Google Scholar 

  95. Cianciotto, N. P., Eisenstein, B. I., Mody, C. H., Toews, G. B., and Engleberg, N. C., 1989, A Legionella pneumophila gene encoding a species-specific surface protein potentiates initiation of intracellular infection, Infect. Immun. 57:1255–1262.

    PubMed  CAS  Google Scholar 

  96. Cianciotto, N. P., Eisenstein, B. I., Mody, C. H., and Engleberg, N. C., 1990, A mutation in the mip gene results in an attenuation of Legionella pneumophila virulence, J. Infect. Dis. 162:121–126.

    Article  PubMed  CAS  Google Scholar 

  97. Cianciotto, N. P., Bangsborg, J. M., Eisenstein, B. I., and Engleberg, N. C., 1990, Identification of mip-like genes in the genus Legionella, Infect. Immun. 58:2912–2918.

    PubMed  CAS  Google Scholar 

  98. Engleberg, N. C., and Eisenstein, B. I., 1991, Progress in the pathogenesis of Legionella pneumophila, Microbiol. Pathogenesis 10:11–13.

    Article  CAS  Google Scholar 

  99. Lundemose, A. G., Birkelund, S., Fey, S. J., Mose Larsen, P., and Christiansen, G., 1991, Chlamydia trachomatis contains a protein similar to the Legionella pneumophila mip gene product, Mol. Microbiol. 5(1):109–115.

    Article  PubMed  CAS  Google Scholar 

  100. Mintz, C. S., Chen, J. X., and Shuman, H. A., 1988, Isolation and characterization of auxotrophic mutants of Legionella pneumophila that fail to multiply in human monocytes, Infect. Immun. 56:1449–1455.

    PubMed  CAS  Google Scholar 

  101. Hoffman, P. S., Houston, L., and Butler, C.A., Legionella pneumophila htpAb heat shock operon: Nucleotide sequence and expression of the 60-Kilodalton antigen in L. pneumophih-infected HeLa cells, Infect. Immun. 58:3380–3387.

    Google Scholar 

  102. Sampson, J., Plikaytis, B., and Wilkinson, H., 1986, Immunologic response of patients with legionellosis against major protein-containing antigens of Legionella pneumophila sero-group 1 as shown by immunoblot analysis, J. Clin. Microbiol. 23:92–99.

    PubMed  CAS  Google Scholar 

  103. Sampson, J. S., O’Connor, S. P., Holloway, B. P., Plikaytis, B. B., Carlone, G. M., and Mayer, L. W., 1990, Nucleotide sequence of htpB, the Legionella pneumophila gene encoding the 58-Kilodalton (kDa) common antigen, formerly designated the 60-kDa common antigen, Infect. Immun. 58:3154–3157.

    PubMed  CAS  Google Scholar 

  104. Blander, S. J., and Horwitz, M. A., 1991, Vaccination with the major secretory protein of Legionella induces humoral and cell-mediated immune response and protective immunity across different serogroups of Legionella pneumophila and different species of Legionella, J. Immunol. 147:285–291.

    PubMed  CAS  Google Scholar 

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© 1994 Springer Science+Business Media New York

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Stout, J.E., Yu, V.L. (1994). Legionella pneumophila. In: Chmel, H., Bendinelli, M., Friedman, H. (eds) Pulmonary Infections and Immunity. Infectious Agents and Pathogenesis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1063-9_6

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  • DOI: https://doi.org/10.1007/978-1-4899-1063-9_6

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