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The Role of the Endothelial Cell Surface Charge for Blood-Brain Barrier Function

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New Concepts of a Blood—Brain Barrier

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Abstract

The glycocalyx is a negatively charged layer of fibrous chains of macromolecules, mainly but not exclusively glycoproteins, that covers the luminal surface of endothelial cells (Luft, 1966, 1976; Burry and Wood, 1979; Simionescu and Simionescu, 1986). In addition, anionic sites are present in the plasmalemma and the basement membrane of brain endothelial cells (Nag, 1985; Vorbrodt, 1989). On the luminal surface the main contributors to the anionic sites are sialic acid residues of acidic glycoproteins. In the basal membranes anionic sites are less abundant and represent a mixture of proteoglycan and acid glycopeptides containing hydrophobic amino acids, sialic acid residues and heparan sulphate-bearing glycosaminoglycans.

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Authors and Affiliations

  1. Department of Neurology, Lund University Hospital, S-221 85, Lund, Sweden

    Barbro B. Johansson

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  1. Barbro B. Johansson
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Editors and Affiliations

  1. Institute of Ophthalmology, University College London, London, England

    John Greenwood

  2. King’s College, University of London, London, England

    David J. Begley

  3. United Medical and Dental Schools, St. Thomas’ Hospital, London, England

    Malcolm B. Segal

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© 1995 Springer Science+Business Media New York

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Johansson, B.B. (1995). The Role of the Endothelial Cell Surface Charge for Blood-Brain Barrier Function. In: Greenwood, J., Begley, D.J., Segal, M.B. (eds) New Concepts of a Blood—Brain Barrier. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1054-7_6

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  • DOI: https://doi.org/10.1007/978-1-4899-1054-7_6

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-1056-1

  • Online ISBN: 978-1-4899-1054-7

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