Abstract
Intracranially-applied tracers are effectively drained via the nasal route and accumulate in the deep cervical lymph nodes of experimental animals1–12. Recently, Löwhagen et al.13 described the nasal drainage routes in man and reported that red blood cells drain via the perineural route from the subarachnoid space to the nasal mucosa in patients with intracranial haemorrhagic lesions. The object of the present paper was to study whether the drainage of cerebrospinal fluid (CSF) to the nasal mucosa could be visualized in man also in the absence of intracranial pressure increase and in patients without a cerebral disorder. For this purpose, the presence of brain-specific antigen was mapped immunocytochemically along the presumed routes of transport in post-mortem material comprising controls without a neurological disorder and patients with various brain lesions.
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Löwhagen, P., Johansson, B.B., Nordborg, C. (1995). Nasal Cerebrospinal Fluid Drainage in Man. In: Greenwood, J., Begley, D.J., Segal, M.B. (eds) New Concepts of a Blood—Brain Barrier. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1054-7_19
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DOI: https://doi.org/10.1007/978-1-4899-1054-7_19
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