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Peptide Transport System-1

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New Concepts of a Blood—Brain Barrier

Abstract

Saturable transport across the blood-brain barrier (BBB) has been described for several peptides (Table 1) and regulatory proteins from numerous laboratories1–5. The existence of transporters at the BBB for regulatory molecules suggests that the BBB may be involved in controlling communication between the central nervous system (CNS) and peripheral organs and tissues. Tyr-MIF-1 (Tyr-Pro-Leu-Gly-NH2) was the first peptide to be definitively shown to cross the BBB by a saturable process6. To distinguish the transporter for Tyr-MIF-1 from that for other, unrelated peptide transporters, the term peptide transport system (PTS)-1 was coined2. We review here some of the salient features of PTS-1 as currently understood.

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Authors and Affiliations

  1. Veterans Affairs Medical Center and Tulane University School of Medicine, New Orleans, LA, 70146, USA

    William A. Banks & Abba J. Kastin

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  1. William A. Banks
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  2. Abba J. Kastin
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Editors and Affiliations

  1. Institute of Ophthalmology, University College London, London, England

    John Greenwood

  2. King’s College, University of London, London, England

    David J. Begley

  3. United Medical and Dental Schools, St. Thomas’ Hospital, London, England

    Malcolm B. Segal

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© 1995 Springer Science+Business Media New York

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Banks, W.A., Kastin, A.J. (1995). Peptide Transport System-1. In: Greenwood, J., Begley, D.J., Segal, M.B. (eds) New Concepts of a Blood—Brain Barrier. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1054-7_12

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  • DOI: https://doi.org/10.1007/978-1-4899-1054-7_12

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-1056-1

  • Online ISBN: 978-1-4899-1054-7

  • eBook Packages: Springer Book Archive

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