Abstract
Butyrylcholinesterase (BCHE) and acetylcholinesterase (ACHE) genes are expressed independently in adult tissues. This can be inferred from the fact that human BCHE mRNA levels are high in liver, lung, and brain while human ACHE mRNA levels are high in brain and muscle (Jbilo et al, 1994). Other evidence is that AChE and BChE activities do not correlate with each other (Edwards and Brimijoin, 1982). However, it has been suggested that BChE activity regulates the expression of AChE during development of the chicken neural tube (Layer, 1991). The explanation for the difference in expression of BChE and AChE must lie in their promoters. In the present work we have identified the minimal promoter for human and rabbit BCHE (Jbilo et al, 1994).
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Arpagaus, M., Kott, M., Vatsis, K.P., Bartels, C.F., La Du, B.N., and Lockridge, O., 1990, Structure of the gene for human butyrylcholinesterase. Evidence for a single copy, Biochemistry 29: 124–131.
Edwards, J.A., and Brimijoin, S., 1982, Divergent regulation of acetylcholinesterase and butyrylcholinesterase in tissues of the rat. J. Neurochem. 38: 1393–1403.
Ekström, T.J., Klump, W.M., Getman, D., Karin, M., and Taylor, P., 1993, Promoter elements and transcriptional regulation of the acetylcholinesterase gene. DNA Cell Biol. 12: 63–72.
Jbilo, O., Bartels, C.F., Chatonnet, A., Toutant, J-P, and Lockridge, O., 1994, Tissue distribution of human acetylcholinesterase and butyrylcholinesterase messenger RNA. Toxicon 32: In Press.
Jbilo, O., Toutant, J-P, Vatsis, K.P., Chatonnet, A. and Lockridge, O., 1994, Promoter and transcription start site of human and rabbit butyrylcholinesterase genes. J. Biol. Chem. 269: 20829–20837.
Layer, P.G., 1991, Cholinesterases during development of the avian nervous system. Cell. Mol. Neurobiol. 11: 7–33.
Li, Y., Camp, S., Rachinsky, T.L., Bongiomo, C., and Taylor, P., 1993, Promoter elements and transcriptional control of the mouse acetylcholinesterase gene. J. Biol. Chem. 268: 3563–3572.
Martin, M.E., Yang, X.Y., and Folk, W.R., 1992, Expression of a 91-kilodalton PEA3-binding protein is down-regulated during differentiation of F9 embryonal carcinoma cells. Mol. Cell. Biol. 12: 2213–2221.
McTiernan, C., Adkins, S., Chatonnet, A., Vaughan, T.A., Bartels, C.F., Kott, M., Rosenberry, T.L., La Du, B.N., and Lockridge, O., 1987, Brain cDNA clone for human cholinesterase. Proc. Natl. Acad. Sci. 84: 6682–6686.
Schöler, H.R., Hatzopoulos, A.K., Balling, R., Suzuki, N., and Gruss, P., 1989, A family of octamer-specific proteins present during mouse embryogenesis: evidence for germline-specific expression of an Oct factor. EMBO J. 8: 2543–2550.
Smale, S.T. and Baltimore, D., 1989, The “Initiator” as a transcription control element. Cell 57: 103–113.
Wasylyk, B., Wasylyk, C., Flores, P., Begue, A., Leprince, D. and Stehelin, D., 1990, The c-ets proto-oncogenes encode transcription factors that cooperate with c-Fos and c-Jun for transcriptional activation. Nature 346: 191–193.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1995 Springer Science+Business Media New York
About this chapter
Cite this chapter
Jbilo, O., Toutant, JP., Chatonnet, A., Lockridge, O. (1995). Butyrylcholinesterase Transcription Start Site and Promoter. In: Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P. (eds) Enzymes of the Cholinesterase Family. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1051-6_4
Download citation
DOI: https://doi.org/10.1007/978-1-4899-1051-6_4
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4899-1053-0
Online ISBN: 978-1-4899-1051-6
eBook Packages: Springer Book Archive