Superfamily and Domain

Organization of Data for Molecular Evolution Studies
  • Winona C. Barker
  • Friedhelm Pfeiffer
  • David G. George


In the mid 1970’s, Dayhoff proposed that all naturally occurring proteins would cluster into families and superfamilies whose members have diverged from common ancestral forms (Dayhoff et al., 1975; Dayhoff, 1976). A similar proposal was made by Emil Zuckerkandl (1975). Estimates of the number of protein superfamilies were in the low thousands. Recently this estimate has been reassessed. Using a variety of criteria for superfamily membership, estimates of the same order of magnitude as the original Dayhoff estimate have been reported (Green et al., 1993; Gonnet et al., 1992; Chothia, 1992).


Homology Class Homology Domain Protein Sequence Database Sulfite Oxidase Orotate Phosphoribosyltransferase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Winona C. Barker
    • 1
  • Friedhelm Pfeiffer
    • 2
  • David G. George
    • 1
  1. 1.Protein Information ResourceNational Biomedical Research FoundationUSA
  2. 2.Martinsried Institute for Protein SequencesMax Planck Institute for BiochemistryMartinsriedGermany

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