Protein Sequence Analysis, Storage and Retrieval
Studies of the structures and amino-acid sequences of proteins, and the relationships between structure and function, are increasing rapidly in terms of the quantity of information available, the number of groups engaged in the field and the areas in which the resultant knowledge is being applied. An obvious impetus results from the projects to determine the entire genetic constitution of humans and other species, which demands interpretation in terms of the proteins which the chromosomal nucleic acid encodes. Many such proteins have been characterised solely as the translations of open reading frames of the nucleic acid code and are likely to be of unknown function and 3-dimensional structure. It seems clear, however, that protein molecules and their constituent domains belong to families that have evolved from a common ancestor and that there may well only be between one and two thousand such families. This number should be compared to the number of proteins for which sequences are so far known (over 80000 in the current release of the OWL composite, non-redundant database (Akrigg et a1..1992; Bleasby & Wootton, 1990) and the 500 or so different proteins whose 3-dimensional structures are known.
KeywordsResidue Type Protein Sequence Analysis Sequence Window Pictorial Display Structure Display
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