Distinctive Class Relationships Within Vertebrate Alcohol Dehydrogenases

  • Lars Hjelmqvist
  • Mats Estonius
  • Hans Jörnvall


Mammalian alcohol dehydrogenases (ADH) constitute a well-studied enzyme system composed of sub-forms at different levels of multiplicity. The family has diverged into a number of different enzymes. At the next level (Fig. 1), fairly different forms (“classes”) of alcohol dehydrogenase, with distinct structural and enzymatic properties, occur. The subsequent level constitutes still more similar forms (“isozymes”) with gradual differences in properties and fewer residue exchanges.


Gene Duplication Alcohol Dehydrogenase Variable Segment Subsequent Mutation Torpedo Electric Organ 
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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Lars Hjelmqvist
    • 1
  • Mats Estonius
    • 1
  • Hans Jörnvall
    • 1
  1. 1.Department of Medical Biochemistry and BiophysicsKarolinska InstitutetS-171 77 StockholmSweden

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