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Regions of Interaction between Nicotinic Acetylcholine Receptor and α-Neurotoxins and Development of a Synthetic Vaccine Against Toxin Poisoning

  • M. Zouhair Atassi
  • Behzod Z. Dolimbek

Abstract

The nicotinic acetylcholine receptor, (AChR) is a membrane protein on the postsynaptic neuromuscular junction. It has a principal role in postsynaptic neuromuscular transmission because it mediates ion flux across the membrane (1–2). The receptor is a pentamer composed of four subunits α2βγδ. Functional studies have focused mostly on the α-subunit because it is responsible for binding acetycholine (3–5) and α-neurotoxins (6). Snake venom postsynaptic neurotoxins form a large family of related proteins of which two subgroups, the long and short neurotoxins, are major constituents. Both long and short neurotoxins are known to bind specifically to the α-chain of AChR in a competitive manner with cholinergic ligands (7–8), but display differences in their association and dissociation kinetics.

Keywords

Acetylcholine Receptor Synthetic Peptide Nicotinic Acetylcholine Receptor Extracellular Part Snake Venom Toxin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • M. Zouhair Atassi
    • 1
  • Behzod Z. Dolimbek
    • 1
  1. 1.Department of BiochemistryBaylor College of MedicineHoustonUSA

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