Identification of the Disulfide Bonds of Human Complement Component C9
C9 is the last acting protein in the complement cascade. Upon interaction with the membrane bound precursor complex, composed of C5b, C6, C7, and C8, C9 undergoes a conformational change from a monomeric globular plasma protein into an oligomeric integral membrane protein, thus generating an amphiphilic channel across the lipid bilayer of the target cell.
KeywordsDisulfide Bond Membrane Attack Complex Cyanogen Bromide Human Complement Thrombospondin Type
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