Identification of the Disulfide Bonds of Human Complement Component C9

Comparison with the Other Components of the Membrane Attack Complex
  • Stephan Lengweiler
  • Johann Schaller
  • Egon E. Rickli


C9 is the last acting protein in the complement cascade. Upon interaction with the membrane bound precursor complex, composed of C5b, C6, C7, and C8, C9 undergoes a conformational change from a monomeric globular plasma protein into an oligomeric integral membrane protein, thus generating an amphiphilic channel across the lipid bilayer of the target cell.


Disulfide Bond Membrane Attack Complex Cyanogen Bromide Human Complement Thrombospondin Type 
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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Stephan Lengweiler
    • 1
  • Johann Schaller
    • 1
  • Egon E. Rickli
    • 1
  1. 1.Institute of BiochemistryUniversity of BernBernSwitzerland

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