Fatigue pp 83-100 | Cite as

Fatigue at the Neuromuscular Junction

Branch Point vs. Presynaptic vs. Postsynaptic Mechanisms
  • G. C. Sieck
  • Y. S. Prakash
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 384)

Abstract

There are several pre- and postsynaptic sites where neuromuscular transmission failure (NTF) can occur, leading to peripheral muscle fatigue. Presynaptic sites of NTF include: axonal branch point conduction block; a failure of excitation-secretion coupling at the presynaptic terminal; reductions in quantal release of ACh; and reductions in quantal size. Postsynaptic sites of NTF include: cholinergic receptor desensitization; and reduced sarcolemmal excitability. Susceptibility to NTF increases with stimulation frequency and is most prevalent in fatigable fast-twitch motor units. In addition, susceptibility to NTF varies with age and with conditions of altered use.

Keywords

Motor Unit Neuromuscular Junction Neuromuscular Transmission MEPP Amplitude Repetitive Stimulation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • G. C. Sieck
    • 1
  • Y. S. Prakash
    • 1
  1. 1.Departments of Anesthesiology and Physiology and BiophysicsMayo Clinic and FoundationRochesterUSA

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