Fatigue pp 57-68 | Cite as

The Role of Intracellular Acidosis in Muscle Fatigue

  • D. G. Allen
  • H. Westerblad
  • J. Lännergren
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 384)


Muscle fatigue is often accompanied by an intracellular acidosis of variable size. The variability reflects the involvement of different metabolic pathways, the presence or absence of blood flow and the effectiveness of pH-regulating pathways. Intracellular acidosis affects many aspects of muscle cell function; for instance it reduces maximal Ca2+-activated force and Ca2+ sensitivity, slows the maximal shortening velocity and prolongs relaxation. However, acidosis is not the only metabolic change in fatigue which causes each of the above, and there are important aspects of muscle fatigue (e.g., the failure of Ca2+ release) which do not appear to be caused by acidosis.


Muscle Fatigue Mouse Skeletal Muscle Myosin Light Chain Phosphorylation Single Muscle Fibre Tetanic Contraction 
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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • D. G. Allen
    • 1
  • H. Westerblad
    • 2
  • J. Lännergren
    • 2
  1. 1.Department of PhysiologyUniversity of SydneyAustralia
  2. 2.Department of Physiology and PharmacologyKarolinska InstitutetStockholmSweden

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