Fatigue pp 457-469 | Cite as

Associations Between Muscle Soreness, Damage, and Fatigue

  • P. M. Clarkson
  • D. J. Newham
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 384)


Eccentric exercise results in muscle soreness, structural damage, prolonged losses in strength and range of motion, and neuromuscular dysfunction. Greater and longer lasting fatigue occurs after eccentric compared with concentric and isometric exercise. Higher forces are achieved during eccentric contractions with less ATP usage and greater increases in temperature. Although mechanisms involved in the damage and repair process are not well understood, active strain during eccentric contractions is suggested to cause the initial damage which increases over 2–3 days, followed by regeneration.


Muscle Damage Eccentric Exercise Apply Physiology Muscle Soreness Eccentric Contraction 
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  1. Abbott BC & Bigland B (1953). The effects of force and speed changes on the rate of oxygen consumption during negative work. Journal of Physiology (London) 120, 319–325.Google Scholar
  2. Abbott BC, Bigland B & Ritchie JM (1952). The physiological cost of negative work. Journal of Physiology (London) 117, 380–390.Google Scholar
  3. Aldridge R, Cady EB, Jones DA & Obletter G (1986). Muscle pain after exercise is linked with an inorganic phosphate increase as shown by 31P NMR. Bioscience Reports 6, 663–667.PubMedCrossRefGoogle Scholar
  4. Beelan A & Sargeant AJ (1991). Effect of fatigue on maximal power output at different contraction velocities in humans. Journal of Applied Physiology 71, 2332–2337.Google Scholar
  5. Bigland Ritchie B & Woods J (1973). Oxygen consumption and integrated electrical activity of muscle during positive and negative work. Journal of Physiology (London) 234, 40P.Google Scholar
  6. Bonde-Petersen F, Henriksson J & Knuttgen HG (1973). Effect of training with eccentric muscle contractions on skeletal muscle metabolites. Acta Physiologica Scandinavica 88, 564–570.PubMedCrossRefGoogle Scholar
  7. Brody IA (1969). Muscle contracture induced by exercise. New England Journal of Medicine 281, 187–192.PubMedCrossRefGoogle Scholar
  8. Byrd SK (1992). Alterations in the sarcoplasmic reticulum: a possible link to exercise-induced muscle damage. Medicine and Science in Sports and Exercise 24, 531–536.PubMedCrossRefGoogle Scholar
  9. Cafarelli E (1988). Force sensation in fresh and fatigued human skeletal muscle. Exercise and Sport Sciences Reviews 16, 139–168.PubMedCrossRefGoogle Scholar
  10. Clarkson PM, Nosaka K & Braun B (1992). Muscle function after exercise-induced muscle damage and rapid adaptation. Medicine and Science in Sports and Exercise 24, 512–520.PubMedGoogle Scholar
  11. Clarkson PM & Tremblay I (1988). Exercise induced muscle damage, repair and adaptations in humans. Journal of Applied Physiology 65, 1–6.PubMedGoogle Scholar
  12. de Haan A, Lodder MAN & Sargeant AJ (1990). Influence of active pre stretch on fatigue of skeletal muscle. Journal of Applied Physiology 62, 268–273.Google Scholar
  13. Duan C, Delp MD, Hayes PD, Delp PD & Armstrong RB (1990). Rat skeletal muscle mitochondria [Ca2+] and injury from downhill running. Journal of Applied Physiology 68, 1241–1251.PubMedGoogle Scholar
  14. Ebbeling CB & Clarkson PM (1989). Exercise-induced muscle damage and adaptation. Sports Medicine 7, 207–234.PubMedCrossRefGoogle Scholar
  15. Enoka RM & Stuart DG (1992). Neurobiology of muscle fatigue. Journal of Applied Physiology 72, 1631–1648.PubMedCrossRefGoogle Scholar
  16. Faulkner JA, Brooks SV & Opiteck JA (1993). Injury to skeletal muscle fibers during contractions. Conditions of occurrence and prevention. Physical Therapy 73, 911–921.PubMedGoogle Scholar
  17. Fleckenstein JL, Canby RC, Parkey RW, Peshock RM (1988). Acute effects of exercise on MR images of skeletal muscle in normal volunteers. American Journal of Radiology 151, 480–485.Google Scholar
  18. Fridén J & Lieber RL (1992). Structural and mechanical basis of exercise-induced muscle injury. Medicine and Science in Sports and Exercise 24, 521–530.PubMedCrossRefGoogle Scholar
  19. Fried R, Jolesz FA, Lorenzo AV, Francis H & Adams DF (1988). Developmental changes in proton magnetic resonance relaxation times of cardiac and skeletal muscle. Investigative Radiology 23, 289–293.PubMedCrossRefGoogle Scholar
  20. Gandevia SC & McKenzie DK (1988). Activation of human muscles at short muscle lengths during maximal static efforts. Journal of Physiology (London) 407, 599–613.Google Scholar
  21. Gülch RW (1994). Force-velocity relations in human skeletal muscle. International Journal of Sports Medicine 15, S2–S10.PubMedCrossRefGoogle Scholar
  22. Hough T (1902). Ergographic studies in muscular soreness. American Journal of Physiology 7, 76–92.Google Scholar
  23. Howell JN, Chlebourn G & Conatser R (1993). Muscle stiffness, strength loss, swelling and soreness following exercise-induced injury in humans. Journal of Physiology (London) 464, 183–196.Google Scholar
  24. Huxley AF (1957). Muscle structure and theories of contraction. Progress in Biophysics and Biophysical Chemistry 7, 255–318.PubMedGoogle Scholar
  25. Jones DA, Newham DJ & Clarkson PM (1987). Skeletal muscle stiffness and pain following eccentric exercise of the elbow flexors. Pain 30, 233–242.PubMedCrossRefGoogle Scholar
  26. Jones DA, Newham DJ, Round JM & Tolfree SEJ (1986) Experimental human muscle damage: morphological changes in relation to other indices of damage. Journal of Physiology (London) 375, 435–448.Google Scholar
  27. Jones DA, Newham DJ & Torgan A (1989). Mechanical influences on long lasting human muscle fatigue and delayed onset pain. Journal of Physiology (London) 412, 415–427.Google Scholar
  28. Katz B (1939). The relation between force and muscular contraction. Journal of Physiology (London) 96, 45–64.Google Scholar
  29. Knuttgen HG, Bonde-Peterson F & Klausen K (1971). Oxygen uptake and heart rate responses to exercise performed with concentric and eccentric muscle contractions. Medicine and Science in Sports 3, 1–5.PubMedGoogle Scholar
  30. Knuttgen HG, Nadel ER, Pandolf KB & Patton JF (1982). Effects of training with eccentric muscle contractions on exercise performance, energy expenditure and body temperature. International Journal of Sports Medicine 3, 13–17.PubMedCrossRefGoogle Scholar
  31. Komi PV (1973). Relationship between muscle tension, EMG and velocity of contraction under concentric and eccentric work. In: Desmedt JE (ed), New Developments in Electromyography and Clinical Neurophysiology, vol 1, pp 596–606. Basel: Karger.Google Scholar
  32. Kroon GW & Naejie M (1991). Recovery of the human biceps electromyogram after heavy eccentric, concentric or isometric exercise. European Journal of Applied Physiology 63, 444–448.CrossRefGoogle Scholar
  33. Kukulka CG (1992). Human skeletal muscle fatigue. In: Currier DP, Nelson RM (eds), Dynamics of Human Biological Tissues, pp 164–181. Philadelphia: FA Davis.Google Scholar
  34. Lieber RL & Fridén J (1993). Muscle damage is not a function of muscle force but active muscle strain. Journal of Applied Physiology 74, 520–526.PubMedGoogle Scholar
  35. Lowe DA, Warren GL, Hayes DA, Farmer MA & Armstrong RB (1994). Eccentric contraction-induced injury of mouse soleus muscle: effect of varying [Ca2+]o. Journal of Applied Physiology 76, 1445–1453.PubMedGoogle Scholar
  36. Mair J, Koller A, Artner-Dworzak E, Haid C, Wicke K, Judmaier W & Puschendorf, B (1992). Effects of exercise on plasma myosin heavy chain fragments and MRI of skeletal muscle. Journal of Applied Physiology 72, 656–663.PubMedGoogle Scholar
  37. McCully KK, Argov Z, Boden BP, Brown RL, Bank WJ & Chance B (1988). Detection of muscle injury with 31-P magnetic resonance spectroscopy. Muscle & Nerve 11, 212–216.CrossRefGoogle Scholar
  38. McCully KK & Faulkner JA (1985). Injury to skeletal muscle fibers of mice following lengthening contractions. Journal of Applied Physiology 59, 119–126.PubMedGoogle Scholar
  39. Miles MP & Clarkson PM (1994). Exercise-induced muscle pain, soreness, and cramps. Journal of Sports Medicine and Physical Fitness 34, 203–216.PubMedGoogle Scholar
  40. Miles MP, Ives J & Vincent KR (1993). Neuromuscular control following maximal eccentric exercise. Medicine and Science in Sports and Exercise 25, S176.CrossRefGoogle Scholar
  41. Morgan DL (1990). New insights into the behavior of muscle during active lengthening. Biophysics Journal 57, 209–221.CrossRefGoogle Scholar
  42. Nadel ER, Bergh U & Saltin B (1972). Body temperatures during negative work exercise. Journal of Applied Physiology 33, 553–558.PubMedGoogle Scholar
  43. Nakazawa K, Kawakami Y, Fukunaga T, Yano H & Miyashita M (1993). Differences in activation patterns in elbow flexor muscles during isometric, concentric and eccentric contractions. European Journal of Applied Physiology 66, 214–220.CrossRefGoogle Scholar
  44. Newham DJ & Cady E (1990). A 31P study of fatigue and metabolism in human skeletal muscle with voluntary, intermittent contractions at different forces. NMR in Biomedicine 3, 211–219.PubMedCrossRefGoogle Scholar
  45. Newham DJ, Jones DA, Ghosh G & Aurora P (1988). Muscle fatigue and pain after eccentric contractions at long and short length. Clinical Science 74, 553–557.PubMedGoogle Scholar
  46. Newham DJ, Jones DA & Clarkson PM (1987). Repeated high force eccentric exercise; effects on muscle pain and damage. Journal of Applied Physiology 63, 1381–1386.PubMedGoogle Scholar
  47. Newham DJ, Mills KR, Quigley BM & Edwards RHT (1983a). Pain and fatigue following concentric and eccentric muscle contractions. Clinical Science 64, 55–62.PubMedGoogle Scholar
  48. Newham DJ, McPhail G, Mills KR & Edwards RHT (1983b). Ultrastructural changes after concentric and eccentric contractions of human muscle. Journal of the Neurological Sciences 61, 109–122.PubMedCrossRefGoogle Scholar
  49. Nosaka K & Clarkson PM (1993). Plasma creatine kinase response to a subsequent bout of eccentric exercise with the contralateral limb. Medicine and Science in Sports and Exercise 25, S33.CrossRefGoogle Scholar
  50. Nosaka K, Clarkson PM & Apple FS (1992). Time course of serum protein changes after strenuous exercise of the forearm flexors. Journal of Laboratory and Clinical Medicine 119, 183–188.PubMedGoogle Scholar
  51. Nurenberg P, Giddings C, Stray-Gundersen J, Fleckenstein JL, Gonyea WJ & Peshock RM (1992). MR imaging-guided muscle biopsy for correlation of increased signal intensity with ultrastructural change and delayed-onset muscle soreness after exercise. Radiology 184, 865–869.PubMedGoogle Scholar
  52. Rodenburg JB, deBoer RW, Schiereck P, van Echeld CJA & Bar PR (1994). Changes in phosphorus compounds and water content in skeletal muscle due to eccentric exercise. European Journal of Applied Physiology 68, 205–213.CrossRefGoogle Scholar
  53. Rutherford OM, Jones DA & Newham DJ (1986). Clinical and experimental application of the percutaneous twitch superimposition technique for the study of human muscle activation. Journal of Neurology, Neurosurgery and Psychiatry 49, 1288–1291.CrossRefGoogle Scholar
  54. Sargeant AJ & Dolan P (1987). Human muscle function following prolonged eccentric exercise. European Journal of Applied Physiology 56, 704–711.CrossRefGoogle Scholar
  55. Saxton JM, Clarkson PM, James R, Miles M, Westerfer M, Clark S & A.E. Donnelly (1994). Neuromuscular function following maximum voluntary eccentric exercise. Medicine and Science in Sports and Exercise 26, S115.CrossRefGoogle Scholar
  56. Shellock FG, Fukunaga T, Mink JH & Edgerton VR (1991). Exertional muscle injury, evaluation of concentric versus eccentric actions with serial MR imaging. Radiology 179, 659–664.PubMedGoogle Scholar
  57. Smith LL (1991). Acute inflammation: the underlying mechanism in delayed onset muscle soreness? Medicine and Science in Sports and Exercise 23, 542–551.PubMedGoogle Scholar
  58. Stauber WT (1989). Eccentric action of muscles, physiology, injury and adaptation. Exercise Sport Sciences Reviews 17, 157–185.Google Scholar
  59. Tidball JG (1991). Myotendinous junction injury in relation to junction structure and molecular composition. Exercise and Sport Sciences Reviews 19, 419–445.PubMedCrossRefGoogle Scholar
  60. Volfmger L, Lassourd V, Michaux JM, Braun JP & Toutain PL (1994). Kinetic evaluation of muscle damage during exercise by calculation of amount of creatine kinase released. American Journal of Physiology 266, R434–441.Google Scholar
  61. Warren GI, Hayes DA, Lowe DA & Armstrong RB (1993a). Mechanical factors in the initiation of eccentric contraction-induced injury in rat soleus muscle. Journal of Physiology (London) 464, 457–475.Google Scholar
  62. Warren GI, Hayes DA, Lowe DA, Prior BM & Armstrong RB (1993b). Materials fatigue initiates eccentric contraction-induced injury in rat soleus muscle. Journal of Physiology (London) 464, 477–489.Google Scholar
  63. Warren GI, Lowe DA, Hayes DA, Karowski CJ, Prior BM & Armstrong RB (1993c). Excitation failure in eccentric contraction-induced injury of mouse soleus muscle. Journal of Physiology (London) 468, 487–499.Google Scholar
  64. Westing SH, Cresswell AG & Thorstensson A (1991). Muscle activation during maximal voluntary eccentric and concentric knee extension. European Journal of Applied Physiology 62, 104–108.CrossRefGoogle Scholar
  65. Woledge RC, Curtin NA & Homsher E (1985). Energetic aspects of muscle contraction. Monographs of the Physiological Society No 41. London: Academic Press.Google Scholar

Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • P. M. Clarkson
    • 1
    • 2
  • D. J. Newham
    • 1
    • 2
  1. 1.Department of Exercise ScienceUniversity of MassachusettsAmherstUSA
  2. 2.Physiotherapy Group, Biomedical Sciences DivisionKing’s CollegeLondonEngland

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