Fatigue pp 393-399 | Cite as

An Integrative View of Limitations to Muscular Performance

  • J. A. Dempsey
  • M. A. Babcock
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 384)


First we describe the changing site of limitation to maximal O2 transport with increasing fitness in mammals. The capacity for diffusion and airway/parenchymal flow rate and volume are markedly overbuilt in the sedentary subject’s lung, but undergo little change with increased training/fitness; accordingly, as demand for O2 transport increases in the highly fit, the limits for maximal diffusion and ventilation are surpassed or met at maximal exercise. Secondly, low-frequency diaphragmatic fatigue occured with by heavy endurance exercise. This fatigue resulted from increased diaphragmatic work together with the major contribution from the secondary effects of increased locomotor muscle activity; namely, metabolic acidosis and increased requirement for blood flow.


Endurance Exercise Apply Physiology Inspiratory Muscle Fatigue Threshold Body Exercise 
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  1. Aaron EA, Seow K, Johnson BD & Dempsey JA (1992). Oxygen cost of exercise hyperpnea: implications for performance. Journal ofApplied Physiology 72, 1818–1825.Google Scholar
  2. Andersen P & Saltin B (1985). Maximal perfusion of skeletal muscle in man. Journal of Physiology (London) 366, 233–249.Google Scholar
  3. Babcock MA, Johnson BD, Pegelow DF, Suman OE, Griffin D & Dempsey JA (1995a). Hypoxic effects on exercise-induced diaphragmatic fatigue in normal healthy humans. Journal of Applied Physiology, 78(1), 82–92.PubMedGoogle Scholar
  4. Babcock MA, Pegelow D & Dempsey JA (1994). Aerobic fitness effects on exercise-induced diaphragm fatigue. American Journal of Respiratory and Critical Care Medicine 149, A799.Google Scholar
  5. Babcock MA, Pegelow DF, Suman O, McClaran SR & Dempsey JA (1995b). Contribution of diaphragmatic work to exercise-induced diaphragm fatigue. Journal of Applied Physiology 78, 1710–1719.PubMedGoogle Scholar
  6. Bayly WM, Hodgon DR, Schulz DA, Dempsey JA & Gollnick PD (1989). Exercise-induced hypercapnia in the horse. Journal of Applied Physiology 67, 1958–1966.PubMedGoogle Scholar
  7. Bellemare F & Bigland-Ritchie B (1984). Assessment of human diaphragm strength and activation using phrenic nerve stimulation. Respiration Physiology 58, 263–277.PubMedCrossRefGoogle Scholar
  8. Bellemare F & Grassino A (1982). Effect of pressure and timing of contraction on human diaphragm fatigue. Journal of Applied Physiology 53, 1190–1195.PubMedCrossRefGoogle Scholar
  9. Catchside PG & Scroop GC (1993). Lactate kinetics in resting and exercising forearms during moderate-intensity supine leg exercise. Journal of Applied Physiology 74, 435–443.Google Scholar
  10. Dempsey JA, Hanson PG & Henderson KS (1984). Exercise-induced arterial hypoxemia in healthy human subjects at sea level. Journal of Physiology (London) 355, 161–175.Google Scholar
  11. Fregosi RF & Dempsey JA (1986). Effects of exercise in normoxia and acute hypoxia on respiratory muscle metabolites. Journal of Applied Physiology 60, 1274–1283.PubMedCrossRefGoogle Scholar
  12. Gandevia SC & McKenzie DK (1985). Activation of the human diaphragm during maximal static efforts. Journal of Physiology (London) 367, 45–56.Google Scholar
  13. Gladden LB, Crawford R & Webster M (1994) Effect of lactate concentration and metabolic rate on net lactate uptake by canine skeletal muscle. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology 35, R1095–Rl101.Google Scholar
  14. Johnson BD, Babcock MA, Suman OE & Dempsey, JA (1993). Exercise-induced diaphragmatic fatigue in healthy humans. Journal of Physiology (London) 460, 385–405.Google Scholar
  15. Johnson BD, Saupe KW & Dempsey JA (1992). Mechanical constraints on exercise hyperpnea in endurance athletes. Journal of Applied Physiology 73, 874–886.PubMedGoogle Scholar
  16. Wagner PD, Hoppler H & Saltin B (1991). Determinants of maximal oxygen uptake. In: Crystal RG, West JB (eds.), The Lung: Scientific Foundations, vol. 2, pp. 1585–1593. New York: Raven Press.Google Scholar
  17. West JB, Tsukimoto K, Mathieu-Costello O & Prediletto, R (1991). Stress failure in pulmonary capillaries. Journal of Applied Physiology 70, 1731–1742.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • J. A. Dempsey
    • 1
  • M. A. Babcock
    • 1
  1. 1.The John Rankin Laboratory of Pulmonary Medicine, Department of Preventive MedicineUniversity of Wisconsin-MadisonMadisonUSA

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