Abstract
First we describe the changing site of limitation to maximal O2 transport with increasing fitness in mammals. The capacity for diffusion and airway/parenchymal flow rate and volume are markedly overbuilt in the sedentary subject’s lung, but undergo little change with increased training/fitness; accordingly, as demand for O2 transport increases in the highly fit, the limits for maximal diffusion and ventilation are surpassed or met at maximal exercise. Secondly, low-frequency diaphragmatic fatigue occured with by heavy endurance exercise. This fatigue resulted from increased diaphragmatic work together with the major contribution from the secondary effects of increased locomotor muscle activity; namely, metabolic acidosis and increased requirement for blood flow.
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© 1995 Springer Science+Business Media New York
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Dempsey, J.A., Babcock, M.A. (1995). An Integrative View of Limitations to Muscular Performance. In: Gandevia, S.C., Enoka, R.M., McComas, A.J., Stuart, D.G., Thomas, C.K., Pierce, P.A. (eds) Fatigue. Advances in Experimental Medicine and Biology, vol 384. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1016-5_31
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DOI: https://doi.org/10.1007/978-1-4899-1016-5_31
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