Fatigue pp 383-391 | Cite as

Fatigue and the Design of the Respiratory System

  • S. L. Lindstedt
  • H. Hoppeler
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 384)


One source of muscle fatigue may be the failure to provide the required oxygen by any step in the oxygen transport cascade or a lack of the necessary machinery to utilize that oxygen. We favor abandoning the concept of a single rate-limiting step for the concept of tuned resistors, each contributing to the overall resistance to oxygen flow. However, because some of these steps have considerably less phenotypic plasticity than others, these are the component parts of the respiratory system that must be built with adequate “reserve” to accommodate adaptive increases in the other steps (Lindstedt et al., 1988; Weibel et al., 1992; Lindstedt et al., 1994). These structures will usually appear to be over built except in those rare individual animals at the species-specific limit of \(\dot V_{O_2 } \) in which these less malleable structures may be limiting.


Endurance Training Capillary Length Mitochondrial Volume Endurance Exercise Training Skeletal Muscle Mitochondrion 
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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • S. L. Lindstedt
    • 1
  • H. Hoppeler
    • 2
  1. 1.Department of Biological SciencesNorthern Arizona UniversityFlagstaffUSA
  2. 2.Department of AnatomyUniversity of BernBernSwitzerland

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