Fatigue pp 281-294 | Cite as

Central Fatigue

Critical Issues, Quantification and Practical Implications
  • S. C. Gandevia
  • G. M. Allen
  • D. K. McKenzie
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 384)


Central fatigue during exercise is the decrease in muscle force attributable to a decline in motoneuronal output. Several methods have been used to assess central fatigue; however, some are limited or not sensitive enough to detect failure in central drive. Central fatigue develops during many forms of exercise. A number of mechanisms may contribute to its development including an increased inhibition mediated by group III and IV muscle afferents along with a decrease in muscle spindle facilitation. In some situations, motor cortical output is shown to be suboptimal. A specific terminology for central fatigue is included.


Motor Unit Maximal Voluntary Contraction Voluntary Activation Apply Physiology Elbow Flexor 
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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • S. C. Gandevia
    • 1
    • 3
  • G. M. Allen
    • 1
  • D. K. McKenzie
    • 1
    • 2
    • 3
  1. 1.Prince of Wales Medical Research InstituteSydneyAustralia
  2. 2.Department of Respiratory Medicine, Prince of Wales HospitalUniversity of New South WalesSydneyAustralia
  3. 3.Division of MedicineUniversity of New South WalesSydneyAustralia

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