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Fatigue pp 281-294 | Cite as

Central Fatigue

Critical Issues, Quantification and Practical Implications
  • S. C. Gandevia
  • G. M. Allen
  • D. K. McKenzie
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 384)

Abstract

Central fatigue during exercise is the decrease in muscle force attributable to a decline in motoneuronal output. Several methods have been used to assess central fatigue; however, some are limited or not sensitive enough to detect failure in central drive. Central fatigue develops during many forms of exercise. A number of mechanisms may contribute to its development including an increased inhibition mediated by group III and IV muscle afferents along with a decrease in muscle spindle facilitation. In some situations, motor cortical output is shown to be suboptimal. A specific terminology for central fatigue is included.

Keywords

Motor Unit Maximal Voluntary Contraction Voluntary Activation Apply Physiology Elbow Flexor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Allen GM, Gandevia SC & McKenzie DK (1993a). Accurate measurements of maximal strength and maximal drive with twitch interpolation. Electroencephalography and Clinical Neurophysiology 86, 52P.CrossRefGoogle Scholar
  2. Allen GM, McKenzie DK, Gandevia SC & Bass S (1993b). Reduced voluntary drive to breathe in asthmatic subjects. Respiration Physiology 93, 29–40.PubMedCrossRefGoogle Scholar
  3. Balestra C, Duchateau J & Hainaut K (1992). Effects of fatigue on the stretch reflex in a human muscle. Electroencephalography and Clinical Neurophysiology 85, 46–52.PubMedCrossRefGoogle Scholar
  4. Belanger AY & McComas AJ (1981). Extent of motor unit activation during effort. Journal of Applied Physiology: Respiratory, Environmental & Exercise Physiology 51, 1131–1135.Google Scholar
  5. Bellemare F & Bigland-Ritchie B (1984). Assessment of human diaphragm strength and activation using phrenic nerve stimulation. Respiration Physiology 58, 263–277.PubMedCrossRefGoogle Scholar
  6. Bellemare F & Bigland-Ritchie B (1987). Central components of diaphragmatic fatigue assessed by phrenic nerve stimulation. Journal of Applied Physiology 62, 1307–1316.PubMedGoogle Scholar
  7. Bellemare F, Woods JJ, Johansson R & Bigland-Ritchie B (1983). Motor-unit discharge rates in maximal voluntary contractions of three human muscles. Journal of Neurophysiology 50, 1380–1392.PubMedGoogle Scholar
  8. Bigland B & Lippold OCJ (1954). Motor unit activity in the voluntary contraction of human muscles. Journal of Physiology (London) 125, 322–335.Google Scholar
  9. Bigland-Ritchie B, Dawson NJ, Johansson RS & Lippold OCJ (1986). Reflex origin for the slowing of motoneurone firing rates in fatigue of human voluntary contractions. Journal of Physiology (London) 379, 451–459.Google Scholar
  10. Bigland-Ritchie B, Furbush FH, Gandevia SC & Thomas CK (1992a). Voluntary discharge frequencies of human motoneurons at different muscle lengths. Muscle & Nerve 15, 130–137.CrossRefGoogle Scholar
  11. Bigland-Ritchie B, Johansson R, Lippold OCJ & Woods JJ (1983). Contractile speed and EMG changes during fatigue of sustained maximal voluntary contractions. Journal of Neurophysiology 50, 313–324.PubMedGoogle Scholar
  12. Bigland-Ritchie B, Jones DA, Hosking GP & Edwards RHT (1978). Central and peripheral fatigue in sustained maximum voluntary contractions of human quadriceps muscle. Clinical Science and Molecular Medicine 54, 609–614.PubMedGoogle Scholar
  13. Bigland-Ritchie B & Rice CL (1994). Comparison of force-frequency relations in human voluntary and stimulated contractions. Proceedings of the Physiological Society, C103.Google Scholar
  14. Bigland-Ritchie B, Thomas CK, Rice CL, Howarth JV & Woods JJ (1992b). Muscle temperature, contractile speed, and motoneuron firing rates during human voluntary contractions. Journal of Applied Physi-ology 73, 2457–2461.Google Scholar
  15. Bongiovanni LG & Hagbarth K-E (1990). Tonic vibration reflexes elicited during fatigue from maximal voluntary contractions in man. Journal of Physiology (London) 423, 1–14.Google Scholar
  16. Brasil-Neto JP, Pascual-Leone A, Valls-solé J, Cammarota A, Cohen LG & Hallet M (1993). Postexercise depression of motor evoked potentials: a measure of central nervous system fatigue. Experimental Brain Research 93, 181–184.CrossRefGoogle Scholar
  17. Brouwer B, Ashby P & Midroni G (1989). Excitability of corticospinal neurons during tonic muscle contractions in man. Experimental Brain Research 74, 649–652.CrossRefGoogle Scholar
  18. Chaouloff F (1991). Cerebral monoamines and fatigue. In Atlan G, Beliveau L, Bouissou P (eds.), Muscle Fatigue: Biochemical and Physiological Aspects, pp. 234–240. Paris: Masson.Google Scholar
  19. De Luca CJ, Lefever RS, McCue MP & Xenakis AP (1982). Behaviour of human motor units in different muscles during linearly varying contractions. Journal of Physiology (London) 329, 113–128.Google Scholar
  20. Duchateau J & Hainaut K (1987). Electrical and mechanical changes in immobilized human muscle. Journal of Applied Physiology 62, 2168–2173.PubMedGoogle Scholar
  21. Fruede F & Ullsperger P (1987). Changes in Bereitschaftspotential during fatiguing and non-fatiguing hand movements. European Journal of Applied Physiology and Occupational Physiology 56, 105–108.CrossRefGoogle Scholar
  22. Gandevia SC (1992). Some central and peripheral factors affecting human motoneuronal output in neuromuscular fatigue. Sports Medicine 13, 93–98.PubMedCrossRefGoogle Scholar
  23. Gandevia SC, Allen GM, Butler JE & Taylor JL (1995). Supraspinal factors in human muscle fatigue: evidence for suboptimal output from the motor cortex. Journal of Physiology (London) In press.Google Scholar
  24. Gandevia SC, Butler JE, Allen GM & Taylor JL (1994) Prolongation of the’ silent’ period following transcranial magnetic stimulation. Proceedings of the Physiological Society, C138.Google Scholar
  25. Gandevia SC, Macefield G, Burke D & McKenzie DK (1990a). Voluntary activation of human motor axons in the absence of muscle afferent feedback. The control of the deafferented hand. Brain 113, 1563–1581.PubMedCrossRefGoogle Scholar
  26. Gandevia SC & McKenzie DK (1985). Activation of the human diaphragm during maximal static efforts. Journal of Physiology (London) 367, 45–56.Google Scholar
  27. Gandevia SC & McKenzie DK (1988). Activation of human muscles at short muscle lengths during maximal static efforts. Journal of Physiology (London) 407, 599–613.Google Scholar
  28. Gandevia SC & McKenzie DK (1993). Central factors in human muscle performance. Proceedings of the International Union of Physiological Sciences 122.6/0.Google Scholar
  29. Gandevia SC, McKenzie DK & Plassman BL (1990b). Activation of human respiratory muscles during different voluntary manoeuvres. Journal of Physiology (London) 428, 387–403.Google Scholar
  30. Garner SC, Sutton JR, Burse RL, McComas AJ, Cymerman A & Houston CS (1990). Operation Everest II: neuromuscular performance under conditions of extreme simulated altitude. Journal of Applied Physiology 68, 1667–1172.Google Scholar
  31. Gooch JL, Newton BY & Petajan JH (1990). Motor unit spike counts before and after maximal voluntary contraction. Muscle & Nerve 13, 1146–1151.CrossRefGoogle Scholar
  32. Grimby L, Hannerz J & Hedman B (1981). The fatigue and voluntary discharge properties of single motor units in man. Journal of Physiology (London) 316, 545–554.Google Scholar
  33. Hales JP & Gandevia SC (1988). Assessment of maximal voluntary contraction with twitch interpolation: an instrument to measure twitch responses. Journal of Neuroscience Methods 25, 97–102.PubMedCrossRefGoogle Scholar
  34. Hayward L, Breitbach D & Rymer Z (1988). Increased inhibitory effects on close synergists during muscle fatigue in the decerebrate cat. Brain Research 440, 199–203.PubMedCrossRefGoogle Scholar
  35. Heyes MP, Garnett ES & Coates G (1985). Central dopaminergic activity influences rats ability to exercise. Life Sciences 36, 671–677.PubMedCrossRefGoogle Scholar
  36. Hill AV (1926). Muscular Activity. Baltimore: Williams & Wilkins.Google Scholar
  37. Howard JD & Enoka RM (1991). Maximum bilateral contractions are modified by neurally mediated interlimb effects. Journal of Applied Physiology 70, 306–316.PubMedGoogle Scholar
  38. Jacobsen S, Wildschiodtz G & Danneskiold-Samsoe B (1991). Isokinetic and isometric muscle strength combined with transcutaneous electrical muscle stimulation in primary fibromyalgia syndrome. Journal of Rheumatology 18, 1390–1393.PubMedGoogle Scholar
  39. Kaufman MP, Rybicki KJ, Waldrop TG & Ordway GA (1984a). Effect of ischemia on responses of group III and IV afferents to contraction. Journal of Applied Physiology 57, 644–650.PubMedGoogle Scholar
  40. Kaufman MP, Waldrop TG, Rybicki KJ, Ordway GA & Mitchell JH (1984b). Effects of static and rhythmic twitch contractions on the discharge of group III and IV muscle afferents. Cardiovascular Research 18, 663–668.PubMedCrossRefGoogle Scholar
  41. Kerneil D & Monster AW (1982). Motoneurone properties and motor fatigue. Experimental Brain Research 46, 197–204.Google Scholar
  42. Killian K (1992). Symptoms limiting exercise. In: Jones NL, Killian KJ (eds.), Breathlessness, pp. 132–142. Hamilton, Canada: Boehringer Ingelheim.Google Scholar
  43. Kukulka CG, Moore MA & Russell AG (1986). Changes in human alpha-motoneuron excitability during sustained maximum isometric contractions. Neuroscience Letters 68, 327–333.PubMedCrossRefGoogle Scholar
  44. Lafleur J, Zytnicki D, Horcholle-Bossavit G & Jami L (1992). Depolarization of Ib afferent axons in the cat spinal cord during homonymous muscle contraction. Journal of Physiology (London) 445, 345–354.Google Scholar
  45. Ljubisavljevic M, Jovanovic K & Anastasijevic R (1992). Changes in discharge rate of fusimotor neurones provoked by fatiguing contractions of cat triceps surae muscles. Journal of Physiology (London) 445, 499–513.Google Scholar
  46. Lloyd AR, Gandevia SC & Hales JP (1991). Muscle performance, voluntary activation, twitch properties and perceived effort in normal subjects and patients with the chronic fatigue syndrome. Brain 114, 85–98.PubMedGoogle Scholar
  47. Loring SH & Hershenson MB (1992). Effects of series compliance on twitches superimposed on voluntary contractions. Journal of Applied Physiology 73, 516–521.PubMedGoogle Scholar
  48. Macefield G, Hagbarth K-E, Gorman R, Gandevia SC & Burke D (1991). Decline in spindle support to alpha motoneurones during sustained voluntary contractions. Journal of Physiology (London) 440, 497–512.Google Scholar
  49. Macefield VG, Gandevia SC, Bigland-Ritchie B, Gorman RB & Burke D (1993). The firing rates of human motoneurones voluntarily activated in the absence of muscle afferent feedback. Journal of Physiology (London) 471, 429–443.Google Scholar
  50. Marsden CD, Meadows JC & Merton PA (1969). Muscular wisdom. Journal of Physiology (London) 200, 15P.Google Scholar
  51. Marsden CD, Meadows JC & Merton PA (1983). “Muscular wisdom” that minimizes fatigue during prolonged effort in man: peak rates of motoneuron discharge and slowing of discharge during fatigue. Advances in Neurology 39, 169–211.PubMedGoogle Scholar
  52. Marsden CD, Merton PA & Morton HB (1980). Maximal twitches from stimulation of the motor cortex in man. Journal of Physiology (London) 312, 5P.Google Scholar
  53. Maton B (1991). Central nervous changes in fatigue induced by local work. In Atlan G, Beliveau L, Bouissou P (eds.), Muscle Fatigue: Biochemical and Physiological Aspects, pp. 207–221. Paris: Masson.Google Scholar
  54. McComas AJ, Kereshi S & Quinlan J (1983). A method for detecting functional weakness. Journal of Neurology, Neurosurgery & Psychiatry 46, 280–282.CrossRefGoogle Scholar
  55. McKenzie DK, Bigland-Ritchie B, Gorman RB & Gandevia SC (1992). Central and peripheral fatigue of human diaphragm and limb muscles assessed by twitch interpolation. Journal of Physiology (London) 454, 643–656.Google Scholar
  56. McKenzie DK & Gandevia SC (1986). Strength and endurance of inspiratory, expiratory, and limb muscles in asthma. American Review of Respiratory Disease 134, 999–1004.PubMedGoogle Scholar
  57. McKenzie DK & Gandevia SC (1991). Recovery from fatigue of human diaphragm and limb muscles. Respiration Physiology 84, 49–60.PubMedCrossRefGoogle Scholar
  58. Merton PA (1954). Voluntary strength and fatigue. Journal of Physiology (London) 123, 553–564.Google Scholar
  59. Meurnier S & Pierrot-Deseilligny E (1989). Gating of the afferent volley of the monosynaptic stretch reflex during movement in man. Journal of Physiology (London) 419, 753–763.Google Scholar
  60. Mosso A (1904). Fatigue. London: Sonnenschein & Co.Google Scholar
  61. Newham DJ, McCarthy T & Turner J (1991). Voluntary activation of human quadriceps during and after isokinetic exercise. Journal of Applied Physiology 71, 2122–2126.PubMedGoogle Scholar
  62. Paintal AS (1960). Functional analysis of group III afferent fibers of mammalian muscles. Journal of Physiology (London) 152, 250–270.Google Scholar
  63. Phillips CG & Porter R (1977). Corticospinal Neurones, Their Role in Movement. London: Academic Press.Google Scholar
  64. Porter R & Lemon R (1993). Corticospinal Function and Voluntary Movement. Oxford: Clarendon Press.Google Scholar
  65. Rutherford OM, Jones DA & Newham DJ (1986). Clinical and experimental application of the percutaneous twitch superimposition technique for the study of human muscle activation. Journal of Neurology, Neurosurgery and Psychiatry 49, 1288–1294.CrossRefGoogle Scholar
  66. Sieck GC & Fournier M (1989). Diaphragm motor unit recruitment during ventilatory and nonventilatory behaviours. Journal of Applied Physiology 66, 2539–2545.PubMedGoogle Scholar
  67. Thomas CK, Bigland-Ritchie B & Johansson RS (1991). Force-frequency relationships of human thenar motor units. Journal of Neurophysiology 65, 1509–1516.PubMedGoogle Scholar
  68. Thomas CK, Woods JJ & Bigland-Ritchie B (1989). Impulse propagation and muscle activation in long maximal voluntary contractions. Journal of Applied Physiology 67, 1835–1842.PubMedGoogle Scholar
  69. Van der Linden DW, Kukulka CG & Soderberg GL (1991). The effect of muscle length on motor unit discharge characteristics in human tibialis anterior muscle. Experimental Brain Research 84, 210–218.CrossRefGoogle Scholar
  70. Vøllestad NK, Sejersted OM, Bahr R, Woods JJ & Bigland-Ritchie B (1988). Motor drive and metabolic responses during repeated submaximal contractions in humans. Journal of Applied Physiology 64, 1421–1427.PubMedGoogle Scholar
  71. Wood L, Ferrell WR & Baxendale RH (1988). Pressures in normal and acutely distended human knee joints and effects on quadriceps maximal voluntary contractions. Quarterly Journal of Experimental Physiology 73, 305–314.PubMedGoogle Scholar
  72. Woods JJ, Furbush F & Bigland-Ritchie B (1987). Evidence for a fatigue-induced reflex inhibition of motoneurone firing rates. Journal of Neurophysiology 58, 125–137.PubMedGoogle Scholar
  73. Yue G & Cole KJ (1992). Strength increases from the motor program: comparison of training with maximal voluntary and imagined muscle contractions. Journal of Neurophysiology 67, 1114–1123.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • S. C. Gandevia
    • 1
    • 3
  • G. M. Allen
    • 1
  • D. K. McKenzie
    • 1
    • 2
    • 3
  1. 1.Prince of Wales Medical Research InstituteSydneyAustralia
  2. 2.Department of Respiratory Medicine, Prince of Wales HospitalUniversity of New South WalesSydneyAustralia
  3. 3.Division of MedicineUniversity of New South WalesSydneyAustralia

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