Abstract
Both metabolic factors and impairment of activation appear to play a role in human muscle fatigue. By measuring force, EMG and metabolites during fatiguing exercise and recovery, we are attempting to estimate the contribution of the different factors which produce fatigue.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Baker AJ, Kostov KG, Miller RG & Weiner MW (1993). Slow force recovery after long duration exercise: Metabolic and activation factors in muscle fatigue. Journal of Applied Physiology 74, 2294–2300.
Bigland-Ritchie B, Cafarelli E & Vollestad NK (1986a). Fatigue of submaximal static contractions. Acta Physiologica Scandinavica 128 (suppl. 556), 137–148.
Bigland-Ritchie B, Furbush F & Woods JJ (1986b). Fatigue of intermittent submaximal voluntary contractions: central and peripheral factors. Journal of Applied Physiology 61, 421–429.
Boska MD, Moussavi RS, Carson PJ, Weiner MW & Miller RG (1990). The metabolic basis of recovery after fatiguing exercise in human muscle. Neurology 40, 240–244.
Cady EB, Elshove H, Jones DA & Moll A (1989a). The metabolic causes of slow relaxation in fatigued human skeletal muscle. Journal of Physiology (London) 418, 327–337.
Cady EB, Jones DA, Lynn J & Newham DJ (1989b). Changes in force and intracellular metabolites during fatigue of human skeletal muscle. Journal of Physiology (London) 418, 311–325.
Chance B, Eleff S, Leigh JS, Sokolow D & Sapega A (1981). Mitochondrial regulation of phosphocreatinephosphate ratios in exercising human muscle: A gated 31P NMR study. Proceedings of the National Academy of Sciences of the United States of America 78, 6714–6718.
Chance B, Leigh JS, Clark BJ, Maris J, Kent J, Nioka S & Smith D (1985). Control of oxidative metabolism and oxygen delivery in human skeletal muscle: A steady-state analysis of the work/energy cost transfer function. Proceedings of the National Academy of Sciences of the United States of America 82, 8384–8388.
Chance B, Leigh JS, Kent J, McCully K, Nioka S, Clark BJ, Maris JM & Graham T (1986). Multiple controls of oxidative metabolism in living tissues as studied by phosphorus magnetic resonance. Proceedings of the National Academy of Sciences of the United States of America 83, 9458–9462.
DeGroot M, Massie BM, Boska M, Gober J, Miller RG & Weiner MW (1993). Dissociation of [H+] from fatigue in human muscle detected by high time resolution 31P-NMR. Muscle & Nerve 16, 91–98.
Edwards RHT (1981). Human muscle function and fatigue. In: Porter R, Whelan J (eds.), Human Muscle Fatigue: Physiological Mechanisms, Ciba Foundation Symposium No. 82, pp. 1–18. London: Pitman Medical.
Edwards RHT, Hill DK, Jones A & Merton PA (1977). Fatigue of long duration in human skeletal muscle after exercise. Journal of Physiology (London) 272, 769–778.
Gandevia SC, McKenzie DK (1985). Activation of the human diaphragm during maximal static efforts. Journal of Physiology (London) 367, 45–56.
Hultman E, Sjöholm H, Sahlin K & Edström L (1981). Glycolytic and oxidative energy metabolism and contraction characteristics of intact human muscle. In: Porter R, Whelan J (eds.), Human Muscle Fatigue: Physiological Mechanisms, Ciba Foundation Symposia No. 82, pp. 19-40. London: Pitman Medical.
Kent-Braun JA, McCully KK & Chance B (1990). Metabolic effects of training in humans: a 31P-MRS study. Journal of Applied Physiology 69, 1165–1170.
Kent-Braun JA, Miller RG, Weiner MW (1994). Magnetic resonance spectroscopy studies of human muscle. Radiologic Clinics of North America 32, 313–335
Kent-Braun JA, Miller RG & Weiner MW (1993a). Phases of metabolism during progressive exercise to fatigue in human skeletal muscle. Journal of Applied Physiology 75, 573–580.
Kent-Braun JA, Miller RG & Weiner MW (1995). Magnetic resonance spectroscopy: studies of human skeletal muscle metabolism in health and disease. In: Holloszy JO (ed.), Exercise and Sport Science Reviews 23, pp. 305–347. Baltimore: Williams and Wilkins.
Kent-Braun JA, Sharma KR, Weiner MW, Massie B & Miller RG (1993b). Central basis of muscle fatigue in chronic fatigue syndrome. Neurology 43, 125–131.
Lloyd AR, Gandevia SC & Hales JP (1991). Muscle performance, voluntary activation, twitch properties and perceived effort in normal subjects and patients with chronic fatigue syndrome. Brain 114, 85–98.
Miller RG, Boska MD, Moussavi R, Carson PJ & Weiner MW (1988). 31P Nuclear magnetic resonance studies of high energy phosphates and pH in human muscle fatigue. Comparison of aerobic and anaerobic exercise. Journal of Clinical Investigation 81, 1190–1196.
Miller RG, Carson PJ, Moussavi RS, Green A, Baker A, Boska MD & Weiner MW (1995). Factors which influence alterations of phosphates and pH in exercising human skeletal muscle: measurement error, reproducibility, and effects of fasting, carbohydrate loading, and metabolic acidosis. Muscle & Nerve 18, 60–67.
Miller RG, Giannini D, Milner-Brown HS, Layzer RB, Koretsky AP, Hooper D & Weiner MW (1987). Effects of fatiguing exercise on high-energy phosphates, force and EMG: Evidence for three phases of recovery. Muscle & Nerve 10, 810–821.
Miller RG, Moussavi RS, Green AT, Carson PJ & Weiner MW (1993). The fatigue of rapid repetitive movements. Neurology 43, 755–761.
Moussavi RS, Carson PJ, Boska MD, Weiner MW & Miller RG (1989). Nonmetabolic fatigue in exercising human muscle. Neurology 39, 1222–1226.
Sharma KR, Weiner MW, Miller RG, Kent-Braun J, Majumdar S, Huang Y & Mynhier M (1995a). Physiology of fatigue in amyotrophic lateral sclerosis. Neurology 45, 733–740.
Sharma KR, Kent-Braun J, Mynhier MA, Weiner MW & Miller RG (1994b). Excessive muscular fatigue in the postpoliomyelitis syndrome. Neurology 44, 642–646.
Sharma KR, Mynhier M & Miller RG (1995c). Muscular fatigue in Duchenne muscular dystrophy. Neurology 45, 306–310.
Taylor DJ, Styles P, Matthews PM, Arnold DA, Gadian DG, Bore P & Radda GK (1986). Energetics of human muscles: Exercise-induced ATP depletion. Magnetic Resonance in Medicine 3, 44–54.
Wang Z, Noyszewski EA & Leigh JS (1990). In vivo MRS measurement of deoxymyoglobin in human forearms. Magnetic Resonance in Medicine 14, 562–567.
Wiener DH, Fink LI, Maris J, Jones RA, Chance B & Wilson JR (1986a). Abnormal skeletal muscle bioenergetics during exercise in patients with heart failure: Role of reduced muscle blood flow. Circulation 73, 1127–1136.
Wiener DH, Maris J, Chance B & Wilson JR (1986b). Detection of skeletal muscle hypoperfusion during exercise using phosphorus-31 nuclear magnetic resonance spectroscopy. Journal of the American College of Cardiology 7, 793–799.
Weiner MW, Moussavi RS, Baker AJ, Boska MD & Miller RG (1990). Constant relationships between force, phosphate concentration, and pH in muscles with differential fatigability. Neurology 40, 1888–1893.
Wilkie DR (1981). Shortage of chemical fuel as a cause of fatigue: studies by nuclear magnetic resonance and bicycle ergometry. In: Porter R, Whelan J (eds.), Human Muscle Fatigue: Physiological Mechanisms, Ciba Foundation Symposium No. 82, pp. 102–119. London: Pitman Medical.
Wilkie DR, Dawson MJ, Edwards RHT, Gordon RE & Shaw D (1984). 31P NMR studies of resting muscle in normal human subjects. In: Pollack, GH & Sugi, H (eds.) Contractile Mechanisms in Muscle, pp. 333–347. New York: Plenum Publishing Corporation.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1995 Springer Science+Business Media New York
About this chapter
Cite this chapter
Miller, R.G., Kent-Braun, J.A., Sharma, K.R., Weiner, M.W. (1995). Mechanisms of Human Muscle Fatigue. In: Gandevia, S.C., Enoka, R.M., McComas, A.J., Stuart, D.G., Thomas, C.K., Pierce, P.A. (eds) Fatigue. Advances in Experimental Medicine and Biology, vol 384. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1016-5_16
Download citation
DOI: https://doi.org/10.1007/978-1-4899-1016-5_16
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4899-1018-9
Online ISBN: 978-1-4899-1016-5
eBook Packages: Springer Book Archive