Human Monocyte/Macrophage Serine Esterase-1: Expression in Haematopoiesis and Transcript Deficiency in Alveolar Macrophages Derived from Patients Affected by Pulmonary Fibrosis

  • F. Zschunke
  • J. Barth
  • H. Kreipe
  • H. J. Radzun
Part of the NATO ASI Series book series (NSSA, volume 266)


Human monocytes and macrophages contain an esterolytic activity that hydrolyses alpha naphthyl acetate (ANA). The sensitivity of the monocyte esterase to the inhibitor diisopropylfluorophosphate classifies this enzyme as a carboxylesterase with a serine residue at the active site which is involved in hydrolysis. ANA cleaving enzymes are also present in other haematopoietic cells. Isoelectric focusing of proteins from purified haemapoietic cells reveals different patterns of ANA cleaving enzymes which are specific for each cell type. Monocytes contain at least five ANA cleaving enzymes with a predominant enzyme activity at pH 5.9 [1].


Healthy Donor Alveolar Macrophage Idiopathic Pulmonary Fibrosis Pulmonary Fibrosis Peritoneal Macrophage 
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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • F. Zschunke
    • 1
  • J. Barth
    • 2
  • H. Kreipe
    • 3
  • H. J. Radzun
    • 1
  1. 1.Center of PathologyGeorg-August University GöttingenGöttingenGermany
  2. 2.Int. Medicine IChristian-Albrecht University KielKielGermany
  3. 3.Inst. for PathologyChristian-Albrecht University KielKielGermany

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