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Liver Carboxylesterases: Topogenesis of Intracellular and Secreted Forms

  • Mariette Robbi
  • Henri Beaufay
Chapter
Part of the NATO ASI Series book series (NSSA, volume 266)

Abstract

In the liver carboxylesterase activity is shared between several isoenzymes which hydrolyse a wide variety of substrates, including therapeutic drugs and xenobiotics. Carboxylesterases act also, in vitro, on endogenous lipid substrates, but the physiological meaning of their action on these compounds is still unclear [1, 2]. Most liver carboxylesterases reside in the lumen of the endoplasmic reticulum (ER) where they are either free, or loosely bound to the inner surface of the membrane [3].

Keywords

Rabbit Liver Endoplasmic Reticulum Lumen Endoplasmic Reticulum Retention Naphthylace Tate Esterase Isoenzyme 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations used

ER

endoplasmic reticulum

endo-H

endo-beta-Nacetylglucosaminidase H

endo-F

endoglycosidase F/N-glycosidase F

PAGE

polyacrylamide gel electrophoresis

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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Mariette Robbi
    • 1
  • Henri Beaufay
    • 1
  1. 1.Laboratoire de Chimie PhysiologiqueUniversité de Louvain and International Institute of Cellular and MolecularPathology, BrusselsBelgium

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