Serum Cholinesterase in Diabetes

  • K. M. Kutty
Chapter
Part of the NATO ASI Series book series (NSSA, volume 266)

Abstract

The history of cholinesterase in regard to its discovery, proposed biological functions and involvement in lipoprotein metabolism is provided as a preamble to explain the rationale behind the relationship between serum cholinesterase and diabetes mellitus.

Keywords

Lipoprotein Metabolism Serum Cholinesterase Serum Triacylglycerols Choline Ester VLDL Level 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Alles, G.A. and Hawes, R.C., Cholinesterase in the blood of man. J. Biol. Chem. 133, (1940) 375–390.Google Scholar
  2. 2.
    Lockridge, O. and Ladu, B.N., Loss of interchain disulfide peptide and dissociation of the tetramer following limited proteolysis of native human serum cholin-esterase. J. Biol. Chem. 257, (1982) 12012–12018.Google Scholar
  3. 3.
    Lockridge, O. and LaDu, B.N., Structure of human butyryl-cholinesterase gene and expression in mammalian cells, in: “Cholinesterases”, J. Massoulie, ed., Amer. Chem. Soc., Washington (1991).Google Scholar
  4. 4.
    Svensmark, O., Molecular properties of cholinesterase. Acta Physiol. Scand. 64, Suppl. 245, (1965) 1–74.Google Scholar
  5. 5.
    Clitherow, J.W., Mitchard, M. and Harper, N.J., The possible biological function of pseudocholinesterase. Nature 199, (1963) 1000–1001.PubMedCrossRefGoogle Scholar
  6. 6.
    Ballantyne, B. and Burwell, R.G., Distribution of cholin-esterase in normal lymph nodes and its possible relation to regulation of tissue size. Nature 206, (1965) 1123–1125.PubMedCrossRefGoogle Scholar
  7. 7.
    Funnell, H.S. and Oliver, W.T., Proposed physiological function for plasma cholinesterase. Nature 208, (1965) 689–690.CrossRefGoogle Scholar
  8. 8.
    Kutty, K.M., Annapurna, V. and Prabhakaran, V., Pseudocholin-esterase: a protein with functions unrelated to its name. Biochem Soc Trans 17, (1989) 555–556.Google Scholar
  9. 9.
    Kutty, K.M., Rowden, G. and Cox, A.R., Interrelationship between serum beta-lipoprotein and cholinesterase. Can. J. Biochem. 51, (1973) 883–887.PubMedCrossRefGoogle Scholar
  10. 10.
    Kutty, K.M., Redheendran, R. and Murphy, D., Serum cholin-esterase, function in lipoprotein metabolism. Experientia 33, (1977) 420–421.PubMedCrossRefGoogle Scholar
  11. 11.
    Kutty, K.M., Jacob, J.C., Hutton, C.J., Davis, P.J. and Peterson, S.C., Serum beta lipoprotein: Studies in a patient and in guinea pigs after the ingestion of organophosphorus compounds. Clin. Biochem. 8, (1975) 379–383.PubMedCrossRefGoogle Scholar
  12. 12.
    Chu, M.I., Fontaine, P., Kutty, K.M., Murphy, D. and Redheendran, R., Cholinesterase in serum and low density lipoprotein of hyperlipidemic patients. Clin. Chim. Acta 85, (1978) 55–59.PubMedCrossRefGoogle Scholar
  13. 13.
    Jain, R., Kutty, K.M., Huang, S.N. and Kean, K., Pseudocholinesterase/high-density lipoprotein cholesterol ratio in serum of normal persons and of hyperlipoproteinemics. Clin. Chem. 29, (1983) 1031–1033.PubMedGoogle Scholar
  14. 14.
    Levy, R.I and Glueck, C.J., Hypertriglyceridemia, diabetes mellitus and coronary vessel disease. Arch. Intern. Med. 123, (1969) 220–228.PubMedCrossRefGoogle Scholar
  15. 15.
    Kutty, K.M., Huang, S.N. and Kean, K., Pseudocholinesterase in obesity hypercaloric diet induced changes in experimental obese mice. Experientia 37, (1981) 1141–1142.PubMedCrossRefGoogle Scholar
  16. 16.
    Kutty, K.M., Kean, K.T., Jain, R. and Huang, S.N., Plasma pseudocholinesterase: A potential marker for early detection of obesity. Nutr. Res. 3, (1983) 211–216.CrossRefGoogle Scholar
  17. 17.
    Kean, K.T., Kutty, K.M., Huang, S.N. and Jain, R., A study of pseudocholinesterase induction in experimental obesity. Jour. Amer. Coll. of Nutr. 5, (1986) 253–261.Google Scholar
  18. 18.
    Kutty, K.M., Jain, R., Kean, K. and Peper, C., Cholinesterase activity in the serum and liver of Zucker fat rats and controls. Nutr. Res. 4, (1984) 99–104CrossRefGoogle Scholar
  19. 19.
    Antopol, W., Tuchman, T. and Schifrin, W., Cholinesterase activity in human serum with special reference to hyperthyroidism. Proc. Soc. Exp. Biol. Med. 36, (1937)46–49.Google Scholar
  20. 20.
    Howard, B.V., Lipoprotein metabolism in diabetes mellitus. J. Lip. Res. 28, (1987) 613–628.Google Scholar
  21. 21.
    Annapurna, V., Senciall, I., Davis, A.J. and Kutty, K.M., Relationship between serum pseudocholinesterase and triglycerides in experimentally induced diabetes mellitus in rats. Diabetologia 34, (1991) 320–324.PubMedCrossRefGoogle Scholar
  22. 22.
    Nikkila, E.A and Kekki, M., Plasma triglyceride transport kinetics in diabetes mellitus. Metabolism 22, (1973)1–22.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • K. M. Kutty
    • 1
  1. 1.Dr. Charles A. Janeway Child Health Centre and Faculty of MedicineMemorial University of NewfoundlandNewfoundlandCanada

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