Study of Some Mechanisms that may Contribute to the Presence of High Levels of Phospholipase A2 Activity in Plasma of Patients with Septicemia

  • Miguel Angel Gijón
  • Carolina García
  • César Pérez
  • Fernando López-Díez
  • Mariano Sánchez-Crespo
Part of the NATO ASI Series book series (NSSA, volume 266)


Phospholipase A2 (EC is a family of phosphatide 2-acylhydrolases that play an important role in the metabolism of phospholipids and membrane homeostasis [1–4]. These functions of phospholipase A2 seem relevant to the pathogenesis of various clinical conditions, since the presence of high concentrations of phospholipase A2 activity in plasma and inflammatory exudates of patients suffering from inflammatory arthritis, peritonitis and septic shock has been reported. Administration of exogenous extracellular phospholipase into experimental animals causes inflammatory hyperemia [5], and a correlation of serum levels of phospholipase A2 with the magnitude of hypotension has been shown in endotoxin shock [6,7]. The possible pathogenetic role of soluble phospholipase A2 in endotoxin shock in connection to the cytokine network has been emphasized by several reports showing the secretion of type II phospholipase A2 by rat mesangial cells [8,9], liver cells [1011] and human synovial cells [12,13] in response to tumor necrosis factor and interleukin lß. A recent report from this laboratory has shown the presence of high amounts of PAF associated with the platelets of patients with septicemia [14] and this raises the question as to whether this finding might be related to the secretion of phospholipase A2 activity and an ensuing formation of lipid mediators.


Sepsis Patient Septic Shock Patient Endotoxin Shock Plasma Enzyme Zymosan Particle 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Miguel Angel Gijón
    • 1
  • Carolina García
    • 1
  • César Pérez
    • 2
  • Fernando López-Díez
    • 3
  • Mariano Sánchez-Crespo
    • 1
  1. 1.Departamento de Bioquímica y FisiologiaFacultad de MedicinaValladolidSpain
  2. 2.Fundación Jiménez DíazMadridSpain
  3. 3.Hospital de la PrincesaMadridSpain

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