Advertisement

Phospholipase A2 in Intensive-Care Patients: The German Multicentre Trial

  • Waldemar H. Uhl
  • Markus W. Büchler
  • the German Phospholipase A2-Study Group
Chapter
Part of the NATO ASI Series book series (NSSA, volume 266)

Abstract

In animal experiments and clinical trials increased circulating catalytic activities of phospholipase A2 were measured in various life-threatening diseases and conditions including septic shock [1–5], ARDS [6], multiple injuries [7], and diffuse peritonitis [8]. There seems to be no longer any question that phospholipases play a major role in the inflammatory responses associated with these diseases [9, 10].

Keywords

Acute Pancreatitis Injury Severity Score Multiple Organ Failure Multiple Injury Sepsis Group 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Schmidt H., Creutzfeld W., The possible role of phospholipase A in the pathogenesis of acute pancreatitis, Scand J Gastroenterol 4: 1969, 39–48.PubMedCrossRefGoogle Scholar
  2. 2.
    Büchler M., Malfertheiner P., Schädlich H. et al., Role of phospholipase A2 in human acute pancreatitis, Gastroenterology 97: 1989, 1521–1526.PubMedGoogle Scholar
  3. 3.
    Vadas P. and Hay J.B., Involvement of circulation phospholipase A2 in the pathogenesis of the hemodynamic changes in endotoxin shock, Can J Physiol Pharmacol 61: 1983, 561–566.PubMedCrossRefGoogle Scholar
  4. 4.
    Vadas P., Elevated plasma phospholipases A2 levels: Correlation with the hemodynamic and pulmonary changes in gram-negative septic shock. J Lab Clin Med 104: 1984, 873–881.PubMedGoogle Scholar
  5. 5.
    Schild A, Pscheidl. E. and v.Hintzenstern U., Phospholipase A–a parameter of sepsis? Klin Wochenschr 67: 1987, 207–211.CrossRefGoogle Scholar
  6. 6.
    Kellermann W., Frentzel-Beyme R, Welte W., et al., Phospholipase A in acute lung injury after trauma and sepsis: its relation to the inflammatory mediators PMN elastase, C3a, and neopterin. Klin Wochenschr 67: 1989, 190–195.PubMedCrossRefGoogle Scholar
  7. 7.
    Uhl W., Büchler M., Nevalainen T.J., et al., Serum phospholipase A2 in patients with multiple injuries. J Trauma 30: 1990, 1285–1290.PubMedCrossRefGoogle Scholar
  8. 8.
    Büchler M., Deller A., Malfertheiner P., et al., Serum phospholipase A2 in intensive care patients with peritonitis, multiple injury, and necrotizing pancreatitis. Klin Wochenschr 67: 1989, 217–221.PubMedCrossRefGoogle Scholar
  9. 9.
    Vadas P. and Pruzanski W., Biology of disease role of secretory phospholipase A2 in the pathobiology of disease. Lab Invest 55: 1986, 391–404.PubMedGoogle Scholar
  10. 10.
    Kaiser E., Chiba P., and Zaky K., Phospholipases in biology and medicine. Clin Biochem 23: 1990, 349–370.PubMedCrossRefGoogle Scholar
  11. 11.
    Goris R.J. A., Boekhorst T.P.A., Nuytinck J.K.S., et al., Multiple organ failure. Arch Surg 120: 1985, 1109–1115.PubMedCrossRefGoogle Scholar
  12. 12.
    Waydhas C., Nast-Kolb D., Jochum M., et al., Inflammatory mediators, infection, sepsis, and multiple organ failure after severe trauma. Arch Surg 127: 1992, 460–467.PubMedCrossRefGoogle Scholar
  13. 13.
    Hoffmann G.E., Schmidt D., Bastian B., et al., Photometric determination of phospholipase A. J Clin Chem Clin Biochem 24: 1986, 871–875.PubMedGoogle Scholar
  14. 14.
    Mustard R.A., Bohnen J.M.A., Haseeb S., et al., C-reactive protein levels predict postoperative septic complications. Arch Surg 122: 1987, 69–73.PubMedCrossRefGoogle Scholar
  15. 15.
    Clark M.A., Chen M.J., Crooke S.T., et al., Tumor necrosis factor (cachectin) induces phospholipase A2 activity and synthesis of a phospholipase A2-activating protein in endothelial cells.Biochem J 250: 1988, 125–132.Google Scholar
  16. 16.
    Crowl R.M., Stoller T.J., Conroy R.R., et al., Induction of phospholipase A2 gene expression in human hepatoma cells by mediators of the acute phase response. J Bio Chem 266: 1991, 2647–2651.Google Scholar

Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Waldemar H. Uhl
    • 1
  • Markus W. Büchler
    • 1
  • the German Phospholipase A2-Study Group
    • 1
  1. 1.Department of Visceral and Transplantation SurgeryUniversity of Berne (Inselspital)BerneSwitzerland

Personalised recommendations