Phospholipase A2 in Intensive-Care Patients: The German Multicentre Trial
In animal experiments and clinical trials increased circulating catalytic activities of phospholipase A2 were measured in various life-threatening diseases and conditions including septic shock [1–5], ARDS , multiple injuries , and diffuse peritonitis . There seems to be no longer any question that phospholipases play a major role in the inflammatory responses associated with these diseases [9, 10].
KeywordsAcute Pancreatitis Injury Severity Score Multiple Organ Failure Multiple Injury Sepsis Group
Unable to display preview. Download preview PDF.
- 15.Clark M.A., Chen M.J., Crooke S.T., et al., Tumor necrosis factor (cachectin) induces phospholipase A2 activity and synthesis of a phospholipase A2-activating protein in endothelial cells.Biochem J 250: 1988, 125–132.Google Scholar
- 16.Crowl R.M., Stoller T.J., Conroy R.R., et al., Induction of phospholipase A2 gene expression in human hepatoma cells by mediators of the acute phase response. J Bio Chem 266: 1991, 2647–2651.Google Scholar